The current practice of dietary advice acknowledges that the “one size fits all” concept fails but scientifically solid tools to differentiate are mostly absent. On top of this, micronutrients collaborate in their activities (e.g., maintaining overall homeostasis in metabolism, oxidative and inflammatory processes). Finally, it now becomes apparent that not only lower levels of intake are of individual concern, but also, for many essential nutrients, upper limits need to be established because of long term negative health effects (examples antioxidant vitamins and death rate, folate and colon cancer recurrence). Assuming that within a foreseeable future the information on the complete (relevant) genomic variation of an individual will become available, it is now time to construct a knowledge basis that will eventually allow for individual optimization of gene-micronutrient interaction and related dietary advice and clinical practice. For this reason, we have started the micronutrient genomics project.
|Eurreca||human variome program|
paper about collaboration