Welcome to the Micronutrients portal at WikiPathways.
From this page, you can access and collaborate in the construction of pathways and networks focused on the biological activity of micronutrients.
This portal is maintained by individual scientists collaborating in the Micronutrient Genomics Project (MGP). The project was described in a publication in Genes and Nutrition. In that paper the need for this portal was described as:
"Essentially, the micronutrient genetics project aims at identifying all relevant genetic variations related to the biological activity on a specific micronutrient. In doing so, we will organize this information in a biological perspective, i.e. pathway and biological network oriented visual browsers. Controversially, for many micronutrients the biological knowledge is still fragmented. Thus, a flexible and editable browser with both a wiki-editable and a permanent interface will be implemented. The genetic variation on specific genes will be derived from the basic databases embedded in the human variome project. A bioinformatics team is established that will construct and maintain these web-based interfaces."
Pathways and Contributors
- Carotenoids and Vitamin A ( human, mouse)
- Effects of Nitric Oxide with protective role of Vitamin C (human)
- Folic acid network (human)
- Iron metabolism in placenta (human)
- Selenium metabolism/Selenoproteins (human)
- Selenium network (human)
- Thyroxine (Thyroid Hormone) production from iodide (human)
- Vitamin B12, folate, one carbon metabolism (human, mouse, rat)
- Vitamin D synthesis (human)
Ben van Ommen, Suzan Wopereis, Susan Coort, Michiel Adriaens, Estibaliz Goyenechea, Jildau Bouwman, Chris Evelo, Lucia Regina Ribeiro, Jerome Compain, Christine Kennedy, Lorraine Gambling and Grietje Holtrop.
About the Micronutrient Genomics project
The current practice of dietary advice acknowledges that the “one size fits all” concept fails but scientifically solid tools to differentiate are mostly absent. On top of this, micronutrients collaborate in their activities (e.g., maintaining overall homeostasis in metabolism, oxidative and inflammatory processes). Finally, it now becomes apparent that not only lower levels of intake are of individual concern, but also, for many essential nutrients, upper limits need to be established because of long term negative health effects (examples antioxidant vitamins and death rate, folate and colon cancer recurrence).
Assuming that within a foreseeable future the information on the complete (relevant) genomic variation of an individual will become available, it is now time to construct a knowledge basis that will eventually allow for individual optimization of gene-micronutrient interaction and related dietary advice and clinical practice. For this reason, we have started the micronutrient genomics project.