Portal:CPTAC

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CPTAC Pathways

Welcome to the CPTAC Pathway Portal

This portal highlights pathway content relevant to the Clinical Proteomic Tumor Analysis Consortium (CPTAC).

The National Cancer Institute, part of the National Institutes of Health, announced the launch of a Clinical Proteomic Tumor Analysis Consortium in August 2011. CPTAC is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of robust, quantitative, proteomic technologies and workflows. The overarching goal of CPTAC is to improve our ability to diagnose, treat and prevent cancer. To achieve this goal in a scientifically rigorous manner, the NCI launched CPTAC to systematically identify proteins that derive from alterations in cancer genomes and related biological processes, and provide this data with accompanying assays and protocols to the public.

CPTAC-logo.png

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Cancer Hallmark Categories

Sustaining proliferative signaling ErbB Signaling Pathway (Homo sapiens)
ErbB Signaling Pathway
Evading growth suppressors G1 to S cell cycle control (Homo sapiens)
G1 to S cell cycle control
Activating invasion and metastasis Epithelial to mesenchymal transition in colorectal cancer (Homo sapiens)
Epithelial to mesenchymal transition in colorectal cancer
Enabling replicative immortality Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds (Homo sapiens)
Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds
Inducing angiogenesis PDGF Pathway (Homo sapiens)
PDGF Pathway
Resisting cell death Apoptosis (Homo sapiens)
Apoptosis
Deregulating cellular energetics Glycolysis and Gluconeogenesis (Homo sapiens)
Glycolysis and Gluconeogenesis
Genome instability and mutation Mismatch repair (Homo sapiens)
Mismatch repair
Tumor promoting inflammation Cytokines and Inflammatory Response (Homo sapiens)
Cytokines and Inflammatory Response
Avoiding immune destruction Interferon type I signaling pathways (Homo sapiens)
Interferon type I signaling pathways
Therapeutics Photodynamic therapy-induced HIF-1 survival signaling (Homo sapiens)
Photodynamic therapy-induced HIF-1 survival signaling

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Featured Pathways

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Pathway Curation

On this page you see rotating displays of hallmark and featured pathways. Where did these pathways come from? They came from people like you! The CPTAC set of pathways can be edited, fixed and added to using the pathway drawing and annotation tools here at WikiPathways.

Getting Started

Resources

Curation projects

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Useful Links