Portal:CPTAC

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CPTAC Pathways

Welcome to the CPTAC Pathway Portal

This portal highlights pathway content relevant to the Clinical Proteomic Tumor Analysis Consortium (CPTAC).

The National Cancer Institute, part of the National Institutes of Health, announced the launch of a Clinical Proteomic Tumor Analysis Consortium in August 2011. CPTAC is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of robust, quantitative, proteomic technologies and workflows. The overarching goal of CPTAC is to improve our ability to diagnose, treat and prevent cancer. To achieve this goal in a scientifically rigorous manner, the NCI launched CPTAC to systematically identify proteins that derive from alterations in cancer genomes and related biological processes, and provide this data with accompanying assays and protocols to the public.

CPTAC-logo.png

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Cancer Hallmark Categories

Sustaining proliferative signaling Ras Signaling (Homo sapiens)
Ras Signaling
Evading growth suppressors TGF-beta Signaling Pathway (Homo sapiens)
TGF-beta Signaling Pathway
Activating invasion and metastasis TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition (Homo sapiens)
TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition
Enabling replicative immortality Notch Signaling Pathway (Homo sapiens)
Notch Signaling Pathway
Inducing angiogenesis Angiogenesis (Homo sapiens)
Angiogenesis
Resisting cell death TP53 Network (Homo sapiens)
TP53 Network
Deregulating cellular energetics Hereditary leiomyomatosis and renal cell carcinoma pathway (Homo sapiens)
Hereditary leiomyomatosis and renal cell carcinoma pathway
Genome instability and mutation Chromosomal and microsatellite instability in colorectal cancer (Homo sapiens)
Chromosomal and microsatellite instability in colorectal cancer
Tumor promoting inflammation Cytokines and Inflammatory Response (Homo sapiens)
Cytokines and Inflammatory Response
Avoiding immune destruction Type II interferon signaling (IFNG) (Homo sapiens)
Type II interferon signaling (IFNG)
Therapeutics LncRNA-mediated mechanisms of therapeutic resistance (Homo sapiens)
LncRNA-mediated mechanisms of therapeutic resistance

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Featured Pathways

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Pathway Curation

On this page you see rotating displays of hallmark and featured pathways. Where did these pathways come from? They came from people like you! The CPTAC set of pathways can be edited, fixed and added to using the pathway drawing and annotation tools here at WikiPathways.

Getting Started

Resources

Curation projects

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Useful Links