Portal:CPTAC

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CPTAC Pathways

Welcome to the CPTAC Pathway Portal

This portal highlights pathway content relevant to the Clinical Proteomic Tumor Analysis Consortium (CPTAC).

The National Cancer Institute, part of the National Institutes of Health, announced the launch of a Clinical Proteomic Tumor Analysis Consortium in August 2011. CPTAC is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of robust, quantitative, proteomic technologies and workflows. The overarching goal of CPTAC is to improve our ability to diagnose, treat and prevent cancer. To achieve this goal in a scientifically rigorous manner, the NCI launched CPTAC to systematically identify proteins that derive from alterations in cancer genomes and related biological processes, and provide this data with accompanying assays and protocols to the public.

CPTAC-logo.png

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Cancer Hallmark Categories

Sustaining proliferative signaling ErbB Signaling Pathway (Homo sapiens)
ErbB Signaling Pathway
Evading growth suppressors TGF-beta Signaling Pathway (Homo sapiens)
TGF-beta Signaling Pathway
Activating invasion and metastasis TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition (Homo sapiens)
TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition
Enabling replicative immortality Wnt Signaling Pathway (Homo sapiens)
Wnt Signaling Pathway
Inducing angiogenesis Hedgehog Signaling Pathway (Homo sapiens)
Hedgehog Signaling Pathway
Resisting cell death Apoptosis (Homo sapiens)
Apoptosis
Deregulating cellular energetics TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer (Homo sapiens)
TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
Genome instability and mutation Regulation of sister chromatid separation at the metaphase-anaphase transition (Homo sapiens)
Regulation of sister chromatid separation at the metaphase-anaphase transition
Tumor promoting inflammation Cytokines and Inflammatory Response (Homo sapiens)
Cytokines and Inflammatory Response
Avoiding immune destruction Type II interferon signaling (IFNG) (Homo sapiens)
Type II interferon signaling (IFNG)
Therapeutics 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression (Homo sapiens)
4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression

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Featured Pathways

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Pathway Curation

On this page you see rotating displays of hallmark and featured pathways. Where did these pathways come from? They came from people like you! The CPTAC set of pathways can be edited, fixed and added to using the pathway drawing and annotation tools here at WikiPathways.

Getting Started

Resources

Curation projects

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Useful Links