Portal:CPTAC

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CPTAC Pathways

Welcome to the CPTAC Pathway Portal

This portal highlights pathway content relevant to the Clinical Proteomic Tumor Analysis Consortium (CPTAC).

The National Cancer Institute, part of the National Institutes of Health, announced the launch of a Clinical Proteomic Tumor Analysis Consortium in August 2011. CPTAC is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of robust, quantitative, proteomic technologies and workflows. The overarching goal of CPTAC is to improve our ability to diagnose, treat and prevent cancer. To achieve this goal in a scientifically rigorous manner, the NCI launched CPTAC to systematically identify proteins that derive from alterations in cancer genomes and related biological processes, and provide this data with accompanying assays and protocols to the public.

CPTAC-logo.png

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Cancer Hallmark Categories

Sustaining proliferative signaling Ras Signaling (Homo sapiens)
Ras Signaling
Evading growth suppressors Retinoblastoma (RB) in Cancer (Homo sapiens)
Retinoblastoma (RB) in Cancer
Activating invasion and metastasis TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition (Homo sapiens)
TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition
Enabling replicative immortality LncRNA involvement in canonical Wnt signaling and colorectal cancer (Homo sapiens)
LncRNA involvement in canonical Wnt signaling and colorectal cancer
Inducing angiogenesis Hedgehog Signaling Pathway (Homo sapiens)
Hedgehog Signaling Pathway
Resisting cell death miRNA regulation of p53 pathway in prostate cancer (Homo sapiens)
miRNA regulation of p53 pathway in prostate cancer
Deregulating cellular energetics Metabolic reprogramming in colon cancer (Homo sapiens)
Metabolic reprogramming in colon cancer
Genome instability and mutation One Carbon Metabolism (Homo sapiens)
One Carbon Metabolism
Tumor promoting inflammation Cytokines and Inflammatory Response (Homo sapiens)
Cytokines and Inflammatory Response
Avoiding immune destruction Type II interferon signaling (IFNG) (Homo sapiens)
Type II interferon signaling (IFNG)
Therapeutics Imatinib and Chronic Myeloid Leukemia (Homo sapiens)
Imatinib and Chronic Myeloid Leukemia

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Featured Pathways

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Pathway Curation

On this page you see rotating displays of hallmark and featured pathways. Where did these pathways come from? They came from people like you! The CPTAC set of pathways can be edited, fixed and added to using the pathway drawing and annotation tools here at WikiPathways.

Getting Started

Resources

Curation projects

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Useful Links