EPO Receptor Signaling (Bos taurus)

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DNA Cell membrane EPOR JAK2 SRC Box-1 Box-2 Y343 P P Y431 P EPOR P P P Y343 Y479 Y460 Box-2 Box-1 P P STAT3 STAT3 P P P SHC1 GRB2 MAP2K1 MAPK3 MAPK1 MAP2K2 RAF1 SOS1 RASA1 P P STAT5B STAT5A P P STAT1 STAT1 EPO EPO PDK1 AKT1 PIK3CG SOCS1 CISH PTPRC PTPRU P P GRB2 RAF1 SOS1 IRS2 JAK2 IRS1 RASA1 Name: EPO Receptor Signaling Organism: Bos taurus


Description

The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Source: Wikipedia

This pathway is based on ScienceSlides.

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Ontology Terms

<OntologyTags></OntologyTags>

Bibliography

  1. Zhu Y, D'Andrea AD; ''The molecular physiology of erythropoietin and the erythropoietin receptor.''; Curr Opin Hematol, 1994 PubMed
  2. Lacombe C, Mayeux P; ''The molecular biology of erythropoietin.''; Nephrol Dial Transplant, 1999 PubMed

History

View all...
RevisionActionTimeUserComment
80789view 08:26, 30 June 2015Mkutmonhomology conversion
67202view 03:20, 26 June 2013Christine ChichesterOntology Term : 'erythropoietin signaling pathway' added !
63457view 10:18, 10 May 2013MaintBotUpdated to 2013 gpml schema
40592view 12:33, 1 March 2011MaintBotRemoved redundant pathway information and comments
35095view 05:58, 11 February 2010Thomasadded literature
33637view 03:06, 1 December 2009MaintBotRemoved group label
30565view 15:04, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProductENSBTAG00000017636 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207
CISHGeneProductENSBTAG00000022622 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1154
EPOGeneProductENSBTAG00000003430 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2056
EPORGeneProductENSBTAG00000008197 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2057
GRB2GeneProductENSBTAG00000004736 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2885
IRS1GeneProductENSBTAG00000021308 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3667
IRS2GeneProductENSBTAG00000012019 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8660
JAK2GeneProductENSBTAG00000012047 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3717
MAP2K1GeneProductENSBTAG00000033983 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604
MAP2K2GeneProductENSBTAG00000024450 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605
MAPK1GeneProductENSBTAG00000010312 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
MAPK3GeneProductENSBTAG00000016156 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595
PDK1GeneProductENSBTAG00000016836 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5163
PIK3CGGeneProductENSBTAG00000020848 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5294
PTPRCGeneProductENSBTAG00000023144 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5788
PTPRUGeneProductENSBTAG00000012848 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10076
RAF1GeneProductENSBTAG00000045748 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894
RASA1GeneProductENSBTAG00000009565 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5921
SHC1GeneProductENSBTAG00000019838 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6464
SOCS1GeneProductENSBTAG00000004386 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8651
SOS1GeneProductENSBTAG00000011643 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6654
SRCGeneProductENSBTAG00000008938 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6714
STAT1GeneProductENSBTAG00000007867 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
STAT3GeneProductENSBTAG00000021523 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774
STAT5AGeneProductENSBTAG00000009496 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6776
STAT5BGeneProductENSBTAG00000010125 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6777

Annotated Interactions

<cite>No annotated interactions</cite>