Difference between revisions of "Pathway:WP996"

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(Ontology Term : 'erythropoietin signaling pathway' added !)
(homology conversion)
 
Line 5: Line 5:
 
This pathway is based on ScienceSlides.</Comment>
 
This pathway is based on ScienceSlides.</Comment>
 
   <Comment Source="WikiPathways-category">Cellular Process</Comment>
 
   <Comment Source="WikiPathways-category">Cellular Process</Comment>
   <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP581&amp;oldid=22574 WP581(r22574)] with a 97% conversion rate.</Comment>
+
   <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP581_r67199 WP581(67199)] with a 100.0% conversion rate.</Comment>
   <BiopaxRef>c5c</BiopaxRef>
+
   <BiopaxRef>c55</BiopaxRef>
   <BiopaxRef>f9e</BiopaxRef>
+
   <BiopaxRef>b16</BiopaxRef>
   <Graphics BoardWidth="1102.0" BoardHeight="822.0"/>
+
   <Graphics BoardWidth="1110.0" BoardHeight="830.0" />
 
   <DataNode TextLabel="EPOR" GraphId="eda83" Type="GeneProduct" GroupRef="df8a7">
 
   <DataNode TextLabel="EPOR" GraphId="eda83" Type="GeneProduct" GroupRef="df8a7">
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="EPOR"/>
+
     <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2057</Comment>
     <Graphics CenterX="453.0" CenterY="193.0" Width="80.0" Height="58.0" ZOrder="-26" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="453.0" CenterY="193.0" Width="80.0" Height="58.0" ZOrder="-26" FontSize="10" Valign="Middle" />
     <Xref Database="Entrez Gene" ID="281144"/>
+
     <Xref Database="Ensembl" ID="ENSBTAG00000008197" />
 
   </DataNode>
 
   </DataNode>
 
   <DataNode TextLabel="JAK2" GraphId="cff3e" Type="GeneProduct" GroupRef="df8a7">
 
   <DataNode TextLabel="JAK2" GraphId="cff3e" Type="GeneProduct" GroupRef="df8a7">
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="JAK2"/>
+
     <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3717</Comment>
     <Graphics CenterX="376.0" CenterY="243.0" Width="80.0" Height="20.0" ZOrder="-22" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="376.0" CenterY="243.0" Width="80.0" Height="20.0" ZOrder="-22" FontSize="10" Valign="Middle" />
     <Xref Database="Entrez Gene" ID="525246"/>
+
     <Xref Database="Ensembl" ID="ENSBTAG00000012047" />
 
   </DataNode>
 
   </DataNode>
 
   <DataNode TextLabel="SRC" GraphId="c4243" Type="GeneProduct" GroupRef="df8a7">
 
   <DataNode TextLabel="SRC" GraphId="c4243" Type="GeneProduct" GroupRef="df8a7">
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="SRC"/>
+
     <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6714</Comment>
     <Graphics CenterX="531.0" CenterY="255.0" Width="80.0" Height="20.0" ZOrder="-19" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="531.0" CenterY="255.0" Width="80.0" Height="20.0" ZOrder="-19" FontSize="10" Valign="Middle" />
     <Xref Database="Entrez Gene" ID="535742"/>
+
     <Xref Database="Ensembl" ID="ENSBTAG00000008938" />
 
   </DataNode>
 
   </DataNode>
 
   <DataNode TextLabel="EPOR" GraphId="ae673" Type="GeneProduct" GroupRef="d829a">
 
   <DataNode TextLabel="EPOR" GraphId="ae673" Type="GeneProduct" GroupRef="d829a">
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="EPOR"/>
+
     <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2057</Comment>
     <Graphics CenterX="680.0" CenterY="195.0" Width="80.0" Height="58.0" ZOrder="-12" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="680.0" CenterY="195.0" Width="80.0" Height="58.0" ZOrder="-12" FontSize="10" Valign="Middle" />
     <Xref Database="Entrez Gene" ID="281144"/>
+
     <Xref Database="Ensembl" ID="ENSBTAG00000008197" />
 
   </DataNode>
 
   </DataNode>
 
   <DataNode TextLabel="STAT1" GraphId="d3f46" Type="GeneProduct" GroupRef="ce0f4">
 
   <DataNode TextLabel="STAT1" GraphId="d3f46" Type="GeneProduct" GroupRef="ce0f4">
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT1"/>
+
     <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772</Comment>
     <Graphics CenterX="141.0" CenterY="418.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="141.0" CenterY="418.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
     <Xref Database="Entrez Gene" ID="510814"/>
+
     <Xref Database="Ensembl" ID="ENSBTAG00000007867" />
 
   </DataNode>
 
   </DataNode>
 
   <DataNode TextLabel="SHC1" GraphId="b79de" Type="GeneProduct" GroupRef="b4157">
 
   <DataNode TextLabel="SHC1" GraphId="b79de" Type="GeneProduct" GroupRef="b4157">
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="SHC1"/>
+
     <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6464</Comment>
     <Graphics CenterX="780.0" CenterY="340.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="780.0" CenterY="340.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
     <Xref Database="Entrez Gene" ID="507196"/>
+
     <Xref Database="Ensembl" ID="ENSBTAG00000019838" />
 
   </DataNode>
 
   </DataNode>
 
   <DataNode TextLabel="GRB2" GraphId="b0bea" Type="GeneProduct" GroupRef="b4157">
 
   <DataNode TextLabel="GRB2" GraphId="b0bea" Type="GeneProduct" GroupRef="b4157">
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="GRB2"/>
+
     <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2885</Comment>
     <Graphics CenterX="780.0" CenterY="360.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="780.0" CenterY="360.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
     <Xref Database="Entrez Gene" ID="535298"/>
+
     <Xref Database="Ensembl" ID="ENSBTAG00000004736" />
 
   </DataNode>
 
   </DataNode>
 
   <DataNode TextLabel="MAP2K1" GraphId="e9a48" Type="GeneProduct" GroupRef="b4157">
 
   <DataNode TextLabel="MAP2K1" GraphId="e9a48" Type="GeneProduct" GroupRef="b4157">
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAP2K1"/>
+
     <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604</Comment>
     <Graphics CenterX="813.0" CenterY="440.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="813.0" CenterY="440.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
     <Xref Database="Entrez Gene" ID="533199"/>
+
     <Xref Database="Ensembl" ID="ENSBTAG00000033983" />
 
   </DataNode>
 
   </DataNode>
 
   <DataNode TextLabel="MAPK3" GraphId="e49ea" Type="GeneProduct" GroupRef="b4157">
 
   <DataNode TextLabel="MAPK3" GraphId="e49ea" Type="GeneProduct" GroupRef="b4157">
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK3"/>
+
     <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595</Comment>
     <Graphics CenterX="813.0" CenterY="480.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="813.0" CenterY="480.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
     <Xref Database="Entrez Gene" ID="531391"/>
+
     <Xref Database="Ensembl" ID="ENSBTAG00000016156" />
 
   </DataNode>
 
   </DataNode>
 
   <DataNode TextLabel="MAPK1" GraphId="fe42f" Type="GeneProduct" GroupRef="b4157">
 
   <DataNode TextLabel="MAPK1" GraphId="fe42f" Type="GeneProduct" GroupRef="b4157">
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK1"/>
+
     <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594</Comment>
     <Graphics CenterX="813.0" CenterY="500.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="813.0" CenterY="500.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
     <Xref Database="Entrez Gene" ID="327672"/>
+
     <Xref Database="Ensembl" ID="ENSBTAG00000010312" />
 
   </DataNode>
 
   </DataNode>
 
   <DataNode TextLabel="MAP2K2" GraphId="ec2ce" Type="GeneProduct" GroupRef="b4157">
 
   <DataNode TextLabel="MAP2K2" GraphId="ec2ce" Type="GeneProduct" GroupRef="b4157">
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAP2K2"/>
+
     <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605</Comment>
     <Graphics CenterX="813.0" CenterY="460.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="813.0" CenterY="460.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
     <Xref Database="Entrez Gene" ID="510434"/>
+
     <Xref Database="Ensembl" ID="ENSBTAG00000024450" />
 
   </DataNode>
 
   </DataNode>
 
   <DataNode TextLabel="PDK1" GraphId="d1fdf" Type="GeneProduct" GroupRef="a6e19">
 
   <DataNode TextLabel="PDK1" GraphId="d1fdf" Type="GeneProduct" GroupRef="a6e19">
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="PDK1"/>
+
     <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5163</Comment>
     <Graphics CenterX="598.0" CenterY="420.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="598.0" CenterY="420.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
     <Xref Database="Entrez Gene" ID="528655"/>
+
     <Xref Database="Ensembl" ID="ENSBTAG00000016836" />
 
   </DataNode>
 
   </DataNode>
 
   <DataNode TextLabel="AKT1" GraphId="fc2b9" Type="GeneProduct" GroupRef="a6e19">
 
   <DataNode TextLabel="AKT1" GraphId="fc2b9" Type="GeneProduct" GroupRef="a6e19">
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="AKT1"/>
+
     <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207</Comment>
     <Graphics CenterX="598.0" CenterY="400.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="598.0" CenterY="400.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
     <Xref Database="Entrez Gene" ID="280991"/>
+
     <Xref Database="Ensembl" ID="ENSBTAG00000017636" />
 
   </DataNode>
 
   </DataNode>
 
   <DataNode TextLabel="PIK3CG" GraphId="ab227" Type="GeneProduct" GroupRef="a6e19">
 
   <DataNode TextLabel="PIK3CG" GraphId="ab227" Type="GeneProduct" GroupRef="a6e19">
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="PIK3CG"/>
+
     <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5294</Comment>
     <Graphics CenterX="598.0" CenterY="380.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="598.0" CenterY="380.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
     <Xref Database="Entrez Gene" ID="530001"/>
+
     <Xref Database="Ensembl" ID="ENSBTAG00000020848" />
 
   </DataNode>
 
   </DataNode>
 
   <DataNode TextLabel="EPO" GraphId="b3cbc" Type="GeneProduct">
 
   <DataNode TextLabel="EPO" GraphId="b3cbc" Type="GeneProduct">
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="EPO"/>
+
     <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2056</Comment>
     <Graphics CenterX="453.0" CenterY="116.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="453.0" CenterY="116.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
     <Xref Database="Entrez Gene" ID="280784"/>
+
     <Xref Database="Ensembl" ID="ENSBTAG00000003430" />
 
   </DataNode>
 
   </DataNode>
 
   <DataNode TextLabel="EPO" GraphId="f5813" Type="GeneProduct">
 
   <DataNode TextLabel="EPO" GraphId="f5813" Type="GeneProduct">
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="EPO"/>
+
     <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2056</Comment>
     <Graphics CenterX="680.0" CenterY="115.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="680.0" CenterY="115.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
     <Xref Database="Entrez Gene" ID="280784"/>
+
     <Xref Database="Ensembl" ID="ENSBTAG00000003430" />
 
   </DataNode>
 
   </DataNode>
 
   <DataNode TextLabel="SOCS1" GraphId="aa3f5" Type="GeneProduct" GroupRef="e49e1">
 
   <DataNode TextLabel="SOCS1" GraphId="aa3f5" Type="GeneProduct" GroupRef="e49e1">
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="SOCS1"/>
+
     <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8651</Comment>
     <Graphics CenterX="192.0" CenterY="276.0" Width="80.0" Height="20.0" ZOrder="32772" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="192.0" CenterY="276.0" Width="80.0" Height="20.0" ZOrder="32772" FontSize="10" Valign="Middle" />
     <Xref Database="Entrez Gene" ID="518795"/>
+
     <Xref Database="Ensembl" ID="ENSBTAG00000004386" />
 
   </DataNode>
 
   </DataNode>
 
   <DataNode TextLabel="STAT5B" GraphId="dcf6d" Type="GeneProduct" GroupRef="d0755">
 
   <DataNode TextLabel="STAT5B" GraphId="dcf6d" Type="GeneProduct" GroupRef="d0755">
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT5B"/>
+
     <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6777</Comment>
     <Graphics CenterX="254.0" CenterY="491.0" Width="80.0" Height="20.0" ZOrder="32774" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="254.0" CenterY="491.0" Width="80.0" Height="20.0" ZOrder="32774" FontSize="10" Valign="Middle" />
     <Xref Database="Entrez Gene" ID="282376"/>
+
     <Xref Database="Ensembl" ID="ENSBTAG00000010125" />
 
   </DataNode>
 
   </DataNode>
 
   <DataNode TextLabel="CISH" GraphId="f14c4" Type="GeneProduct" GroupRef="e49e1">
 
   <DataNode TextLabel="CISH" GraphId="f14c4" Type="GeneProduct" GroupRef="e49e1">
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="CISH"/>
+
     <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1154</Comment>
     <Graphics CenterX="192.0" CenterY="296.0" Width="80.0" Height="20.0" ZOrder="32776" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="192.0" CenterY="296.0" Width="80.0" Height="20.0" ZOrder="32776" FontSize="10" Valign="Middle" />
     <Xref Database="Entrez Gene" ID="616753"/>
+
     <Xref Database="Ensembl" ID="ENSBTAG00000022622" />
 
   </DataNode>
 
   </DataNode>
 
   <DataNode TextLabel="STAT5A" GraphId="ccc1a" Type="GeneProduct" GroupRef="d0755">
 
   <DataNode TextLabel="STAT5A" GraphId="ccc1a" Type="GeneProduct" GroupRef="d0755">
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT5A"/>
+
     <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6776</Comment>
     <Graphics CenterX="254.0" CenterY="471.0" Width="80.0" Height="20.0" ZOrder="32778" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="254.0" CenterY="471.0" Width="80.0" Height="20.0" ZOrder="32778" FontSize="10" Valign="Middle" />
     <Xref Database="Entrez Gene" ID="282375"/>
+
     <Xref Database="Ensembl" ID="ENSBTAG00000009496" />
 
   </DataNode>
 
   </DataNode>
 
   <DataNode TextLabel="STAT3" GraphId="f64b4" Type="GeneProduct" GroupRef="b128c">
 
   <DataNode TextLabel="STAT3" GraphId="f64b4" Type="GeneProduct" GroupRef="b128c">
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT3"/>
+
     <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774</Comment>
     <Graphics CenterX="375.0" CenterY="573.0" Width="80.0" Height="20.0" ZOrder="32780" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="375.0" CenterY="573.0" Width="80.0" Height="20.0" ZOrder="32780" FontSize="10" Valign="Middle" />
     <Xref Database="Entrez Gene" ID="508541"/>
+
     <Xref Database="Ensembl" ID="ENSBTAG00000021523" />
 
   </DataNode>
 
   </DataNode>
 
   <DataNode TextLabel="STAT3" GraphId="e22d7" Type="GeneProduct" GroupRef="b128c">
 
   <DataNode TextLabel="STAT3" GraphId="e22d7" Type="GeneProduct" GroupRef="b128c">
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT3"/>
+
     <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774</Comment>
     <Graphics CenterX="375.0" CenterY="553.0" Width="80.0" Height="20.0" ZOrder="32782" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="375.0" CenterY="553.0" Width="80.0" Height="20.0" ZOrder="32782" FontSize="10" Valign="Middle" />
     <Xref Database="Entrez Gene" ID="508541"/>
+
     <Xref Database="Ensembl" ID="ENSBTAG00000021523" />
 
   </DataNode>
 
   </DataNode>
 
   <DataNode TextLabel="STAT1" GraphId="a6b33" Type="GeneProduct" GroupRef="ce0f4">
 
   <DataNode TextLabel="STAT1" GraphId="a6b33" Type="GeneProduct" GroupRef="ce0f4">
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT1"/>
+
     <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772</Comment>
     <Graphics CenterX="141.0" CenterY="398.0" Width="80.0" Height="20.0" ZOrder="32784" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="141.0" CenterY="398.0" Width="80.0" Height="20.0" ZOrder="32784" FontSize="10" Valign="Middle" />
     <Xref Database="Entrez Gene" ID="510814"/>
+
     <Xref Database="Ensembl" ID="ENSBTAG00000007867" />
 
   </DataNode>
 
   </DataNode>
 
   <DataNode TextLabel="PTPRC" GraphId="d4530" Type="GeneProduct" GroupRef="e2ef6">
 
   <DataNode TextLabel="PTPRC" GraphId="d4530" Type="GeneProduct" GroupRef="e2ef6">
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="PTPRC"/>
+
     <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5788</Comment>
     <Graphics CenterX="142.0" CenterY="184.0" Width="44.0" Height="74.0" ZOrder="32786" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="142.0" CenterY="184.0" Width="44.0" Height="74.0" ZOrder="32786" FontSize="10" Valign="Middle" />
     <Xref Database="Entrez Gene" ID="407152"/>
+
     <Xref Database="Ensembl" ID="ENSBTAG00000023144" />
 
   </DataNode>
 
   </DataNode>
 
   <DataNode TextLabel="PTPRU" GraphId="aacad" Type="GeneProduct" GroupRef="e2ef6">
 
   <DataNode TextLabel="PTPRU" GraphId="aacad" Type="GeneProduct" GroupRef="e2ef6">
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="PTPRU"/>
+
     <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10076</Comment>
     <Graphics CenterX="142.0" CenterY="231.0" Width="80.0" Height="20.0" ZOrder="32790" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="142.0" CenterY="231.0" Width="80.0" Height="20.0" ZOrder="32790" FontSize="10" Valign="Middle" />
     <Xref Database="Entrez Gene" ID="535675"/>
+
     <Xref Database="Ensembl" ID="ENSBTAG00000012848" />
 
   </DataNode>
 
   </DataNode>
 
   <DataNode TextLabel="GRB2" GraphId="c9c65" Type="GeneProduct" GroupRef="c9c1c">
 
   <DataNode TextLabel="GRB2" GraphId="c9c65" Type="GeneProduct" GroupRef="c9c1c">
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="GRB2"/>
+
     <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2885</Comment>
     <Graphics CenterX="889.0" CenterY="239.0" Width="80.0" Height="20.0" ZOrder="32802" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="889.0" CenterY="239.0" Width="80.0" Height="20.0" ZOrder="32802" FontSize="10" Valign="Middle" />
     <Xref Database="Entrez Gene" ID="535298"/>
+
     <Xref Database="Ensembl" ID="ENSBTAG00000004736" />
 
   </DataNode>
 
   </DataNode>
 
   <DataNode TextLabel="RAF1" GraphId="b1bb8" Type="GeneProduct" GroupRef="c9c1c">
 
   <DataNode TextLabel="RAF1" GraphId="b1bb8" Type="GeneProduct" GroupRef="c9c1c">
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="RAF1"/>
+
     <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894</Comment>
     <Graphics CenterX="889.0" CenterY="299.0" Width="80.0" Height="20.0" ZOrder="32803" FontSize="10" Valign="Middle"/>
+
     <Graphics CenterX="889.0" CenterY="299.0" Width="80.0" Height="20.0" ZOrder="32803" FontSize="10" Valign="Middle" />
     <Xref Database="Entrez Gene" ID="521196"/>
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    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8660</Comment>
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     <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3717</Comment>
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     <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3667</Comment>
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     <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5921</Comment>
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     <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894</Comment>
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     <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6654</Comment>
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     <Comment>Not sure if complex consists of both A and B isoforms [thomas-081110]</Comment>
 
     <Comment>Not sure if complex consists of both A and B isoforms [thomas-081110]</Comment>
 
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Line 411: Line 426:
 
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">D'Andrea AD</bp:AUTHORS>
 
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   <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"><bp:TERM>erythropoietin signaling pathway</bp:TERM><bp:ID>PW:0000987</bp:ID><bp:Ontology>Pathway Ontology</bp:Ontology></bp:openControlledVocabulary></Biopax>
 
 
</Pathway>
 
</Pathway>

Latest revision as of 08:26, 30 June 2015

DNA Cell membrane EPOR JAK2 SRC Box-1 Box-2 Y343 P P Y431 P EPOR P P P Y343 Y479 Y460 Box-2 Box-1 P P STAT3 STAT3 P P P SHC1 GRB2 MAP2K1 MAPK3 MAPK1 MAP2K2 RAF1 SOS1 RASA1 P P STAT5B STAT5A P P STAT1 STAT1 EPO EPO PDK1 AKT1 PIK3CG SOCS1 CISH PTPRC PTPRU P P GRB2 RAF1 SOS1 IRS2 JAK2 IRS1 RASA1 Name: EPO Receptor Signaling Organism: Bos taurus


Description

The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Source: Wikipedia

This pathway is based on ScienceSlides.

Quality Tags

Ontology Terms

<OntologyTags></OntologyTags>

Bibliography

  1. Zhu Y, D'Andrea AD; ''The molecular physiology of erythropoietin and the erythropoietin receptor.''; Curr Opin Hematol, 1994 PubMed
  2. Lacombe C, Mayeux P; ''The molecular biology of erythropoietin.''; Nephrol Dial Transplant, 1999 PubMed

History

View all...
RevisionActionTimeUserComment
80789view 08:26, 30 June 2015Mkutmonhomology conversion
67202view 03:20, 26 June 2013Christine ChichesterOntology Term : 'erythropoietin signaling pathway' added !
63457view 10:18, 10 May 2013MaintBotUpdated to 2013 gpml schema
40592view 12:33, 1 March 2011MaintBotRemoved redundant pathway information and comments
35095view 05:58, 11 February 2010Thomasadded literature
33637view 03:06, 1 December 2009MaintBotRemoved group label
30565view 15:04, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProductENSBTAG00000017636 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207
CISHGeneProductENSBTAG00000022622 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1154
EPOGeneProductENSBTAG00000003430 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2056
EPORGeneProductENSBTAG00000008197 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2057
GRB2GeneProductENSBTAG00000004736 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2885
IRS1GeneProductENSBTAG00000021308 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3667
IRS2GeneProductENSBTAG00000012019 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8660
JAK2GeneProductENSBTAG00000012047 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3717
MAP2K1GeneProductENSBTAG00000033983 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604
MAP2K2GeneProductENSBTAG00000024450 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605
MAPK1GeneProductENSBTAG00000010312 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
MAPK3GeneProductENSBTAG00000016156 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595
PDK1GeneProductENSBTAG00000016836 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5163
PIK3CGGeneProductENSBTAG00000020848 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5294
PTPRCGeneProductENSBTAG00000023144 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5788
PTPRUGeneProductENSBTAG00000012848 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10076
RAF1GeneProductENSBTAG00000045748 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894
RASA1GeneProductENSBTAG00000009565 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5921
SHC1GeneProductENSBTAG00000019838 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6464
SOCS1GeneProductENSBTAG00000004386 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8651
SOS1GeneProductENSBTAG00000011643 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6654
SRCGeneProductENSBTAG00000008938 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6714
STAT1GeneProductENSBTAG00000007867 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
STAT3GeneProductENSBTAG00000021523 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774
STAT5AGeneProductENSBTAG00000009496 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6776
STAT5BGeneProductENSBTAG00000010125 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6777

Annotated Interactions

<cite>No annotated interactions</cite>