EPO Receptor Signaling (Homo sapiens)

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DNA Cell membrane EPOR JAK2 SRC Box-1 Box-2 Y343 P P Y431 P EPOR P P P Y343 Y479 Y460 Box-2 Box-1 P P STAT3 STAT3 P P P SHC1 GRB2 MEK1 ERK1 ERK2 MEK2 RAF1 SOS1 RAS P P STAT5B STAT5A P P STAT1 STAT1 EPO EPO PDK1 PKB PI3K SOCS1 CISH CD45 PTP P P GRB2 RAF1 SOS1 IRS2 JAK2 IRS1 RASA1 Name: EPO Receptor Signaling Organism: Homo sapiens


The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Source: Wikipedia

This pathway is based on ScienceSlides.

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Ontology Terms



  1. Lacombe C, Mayeux P; ''The molecular biology of erythropoietin.''; Nephrol Dial Transplant, 1999 PubMed
  2. Zhu Y, D'Andrea AD; ''The molecular physiology of erythropoietin and the erythropoietin receptor.''; Curr Opin Hematol, 1994 PubMed


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86897view 00:58, 14 July 2016MkutmonOntology Term : 'oxidative phosphorylation pathway' added !
67199view 03:19, 26 June 2013Christine ChichesterOntology Term : 'erythropoietin signaling pathway' added !
63183view 13:43, 8 May 2013MaintBotUpdating gpml version
41162view 16:41, 1 March 2011MaintBotRemoved redundant pathway information and comments
35091view 05:54, 11 February 2010Thomasadded literature
32158view 07:03, 14 August 2009MaintBotFixed group labels
22574view 06:25, 14 November 2008ThomasNew pathway

External references


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NameTypeDatabase referenceComment
CD45GeneProduct5788 (Entrez Gene)
CISHGeneProduct1154 (Entrez Gene)
EPOGeneProduct2056 (Entrez Gene)
EPORGeneProduct2057 (Entrez Gene)
ERK1GeneProduct5595 (Entrez Gene)
ERK2GeneProduct5594 (Entrez Gene)
GRB2GeneProduct2885 (Entrez Gene)
IRS1GeneProduct3667 (Entrez Gene)
IRS2GeneProduct8660 (Entrez Gene)
JAK2GeneProduct3717 (Entrez Gene)
MEK1GeneProduct5604 (Entrez Gene)
MEK2GeneProduct5605 (Entrez Gene)
PDK1GeneProduct5163 (Entrez Gene)
PI3KGeneProduct5294 (Entrez Gene)
PKBGeneProduct207 (Entrez Gene)
PTPGeneProduct10076 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene)
RASGeneProduct5921 (Entrez Gene)
RASA1GeneProduct5921 (Entrez Gene)
SHC1GeneProduct6464 (Entrez Gene)
SOCS1GeneProduct8651 (Entrez Gene)
SOS1GeneProduct6654 (Entrez Gene)
SRCGeneProduct6714 (Entrez Gene)
STAT1GeneProduct6772 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
STAT5AGeneProduct6776 (Entrez Gene)
STAT5BGeneProduct6777 (Entrez Gene)

Annotated Interactions

<cite>No annotated interactions</cite>