TCA Cycle and Invasiveness of Ovarian Cancer (Homo sapiens)

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Tyrosine phosphorylation pathway Complex I NADH-Ubiquinone Complex II Succinate-Ubiquinone Low-invasive Ovarian Cancer Cancer stage Legend Tyr-P STAT3 Lactate JAK1 D-Glutamine Pyruvate Glucose EGFR TCA Cycle ERK1 ERK2 Glucose Ser-P STAT3 Glucose EGFR JAK1 Tyr-P STAT3 High-invasive Ovarian Cancer Serine phosphorylation pathway Metabolix flux Name: TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer Organism: Homo sapiens


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Ontology Terms



  1. Yang L, Moss T, Mangala LS, Marini J, Zhao H, Wahlig S, Armaiz-Pena G, Jiang D, Achreja A, Win J, Roopaimoole R, Rodriguez-Aguayo C, Mercado-Uribe I, Lopez-Berestein G, Liu J, Tsukamoto T, Sood AK, Ram PT, Nagrath D; ''Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer.''; Mol Syst Biol, 2014 PubMed


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98142view 17:02, 19 November 2018AlexanderPicoModified title
98141view 17:01, 19 November 2018AlexanderPico
90260view 16:06, 27 October 2016AlexanderPicoChanged Stat3 to default node color
89885view 06:01, 6 October 2016MkutmonModified description
78079view 16:52, 30 November 2014Khanspersfixed unconnected interactions
77985view 11:05, 4 November 2014KhanspersAdded lit ref and fixed arrow
77984view 11:04, 4 November 2014KhanspersOntology Term : 'reproductive system disease' added !
77983view 11:03, 4 November 2014KhanspersModified description
77956view 12:38, 30 October 2014KhanspersOntology Term : 'altered citric acid cycle pathway' added !
77955view 12:34, 30 October 2014KhanspersOntology Term : 'cancer' added !
77954view 12:34, 30 October 2014KhanspersModified description
77917view 13:00, 29 October 2014KhanspersModified title
77916view 12:59, 29 October 2014KhanspersNew pathway

External references


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NameTypeDatabase referenceComment
D-GlutamineMetaboliteHMDB03423 (HMDB)
EGFRGeneProduct1956 (Entrez Gene)
ERK1GeneProduct5595 (Entrez Gene)
ERK2GeneProduct5594 (Entrez Gene)
GlucoseMetaboliteHMDB00122 (HMDB)
JAK1GeneProduct3716 (Entrez Gene)
LactateMetaboliteHMDB00190 (HMDB)
PyruvateMetaboliteHMDB00243 (HMDB)
STAT3GeneProduct6774 (Entrez Gene)
TCA CyclePathwayWP78 (WikiPathways)

Annotated Interactions

<cite>No annotated interactions</cite>