Methylation Pathways (Homo sapiens)

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O-methylation N-methylation S-methylation SAM synthesis (co-substrate) Substrate O-methylated substrate N-methylated substrate S-methylated substrate COMT S-Adenosylmethionine S-Adenosylhomocysteine TPMT S-Adenosylhomocysteine S-Adenosylmethionine S-Adenosylhomocysteine S-Adenosylmethionine L-Methionine ATP NNMT HNMT INMT PNMT MAT1A MAT2A MAT2B Phosphate Phosphate Name: Methylation Pathways Last Modified: 2/22/2013 Organism: Homo sapiens


Quality Tags

Ontology Terms



  1. Weinshilboum RM; ''Pharmacogenomics: catechol O-methyltransferase to thiopurine S-methyltransferase.''; Cell Mol Neurobiol, 2006 PubMed
  2. Testa B, Kramer SD; ''The biochemistry of drug metabolism--an introduction: part 4. reactions of conjugation and their enzymes.''; Chem Biodivers, 2008 PubMed


View all...
88909view 02:24, 17 August 2016MirellaKalafatiOntology Term : 'classic metabolic pathway' added !
79563view 09:07, 25 March 2015ZariChanged ID for INMT gene
68981view 10:42, 8 July 2013MaintBotUpdated to 2013 gpml schema
59186view 11:51, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
44906view 03:26, 6 October 2011MartijnVanIerselOntology Term : 'protein modification pathway' added !
41158view 16:41, 1 March 2011MaintBotRemoved redundant pathway information and comments
39758view 00:23, 17 January 2011AlexanderPicomore specific title
33416view 07:51, 30 November 2009MaintBotRemoved group label
30265view 13:06, 25 July 2009AlexanderPico
30035view 03:24, 29 June 2009Pieter GiesbertzAdded literature reference
30033view 02:38, 29 June 2009Pieter GiesbertzAdded literature reference
29741view 15:38, 1 June 2009KhanspersModified categories
29687view 04:37, 27 May 2009Pieter GiesbertzSpecify description
29671view 01:09, 26 May 2009Pieter GiesbertzAdded co-substrate synthesis
29349view 00:55, 28 April 2009Pieter GiesbertzNew pathway

External references


View all...
NameTypeDatabase referenceComment
ATPMetaboliteHMDB00538 (HMDB)
COMTGeneProductENSG00000093010 (Ensembl)
HNMTGeneProductENSG00000150540 (Ensembl)
INMTGeneProductENSG00000241644 (Ensembl)
L-MethionineMetaboliteHMDB00696 (HMDB)
MAT1AGeneProductENSG00000151224 (Ensembl)
MAT2AGeneProductENSG00000168906 (Ensembl)
MAT2BGeneProductENSG00000038274 (Ensembl)
N-methylated substrateMetabolite
NNMTGeneProductENSG00000166741 (Ensembl)
O-methylated substrateMetabolite
PNMTGeneProductENSG00000141744 (Ensembl)
PhosphateMetaboliteHMDB01429 (HMDB)
S-AdenosylhomocysteineMetaboliteHMDB00939 (HMDB)
S-AdenosylmethionineMetaboliteHMDB01185 (HMDB)
S-methylated substrateMetabolite
TPMTGeneProductENSG00000137364 (Ensembl)

Annotated Interactions

<cite>No annotated interactions</cite>