Type II interferon signaling (IFNG) (Homo sapiens)

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B O B -P AP OR P B B B O P P T T T P OR OR & & OR OR Nucleus Extracellular Space Plasma Membrane Cytoplasm [P] IFNGR2 IFNG JAK1 JAK2 IFNGR1 [P] STAT1 STAT1 [P] [P] STAT1 STAT1 [P] STAT1 STAT1 IFNG JAK2 IFNGR2 IFNGR1 JAK1 SOCS3 SOCS1 PTPN11 STAT1 STAT1 [P] STAT2 [P] IRF9 PRKCD PTP IRF4 SPI1 IFNA IFNB1 HLA-B NOS2A GBP1 HIST2H4 PSMB9 TAP1 OAS1 CXCL10 CIITA CYBB IL1B IFIT2 EIF2AK2 G1P3 IRF1 ICAM1 CXCL9 G1P2 IRF8 [P] IRF8 IRF2 IFNG IFNG IFNGR1 IFNGR2 JAK1 JAK2 JAK2 IFNGR2 IFNGR1 JAK1 IFNG STAT2 STAT1 STAT2 STAT1 IRF9 (ISGF3) STAT1 STAT1 IRF9 STAT1 STAT1 STAT2 STAT1 IRF9 (ISGF3) STAT1 STAT1 IRF9 Name: Type II interferon signaling (IFNG) Organism: Homo sapiens


Description

Adapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several transcriptionally active complexes are formed (STAT1 homodimer, ISGF3 complex, STAT1:STAT1:IRF9 complex) and the pathway culminates with the transcriptional activation of target genes. [1]

Quality Tags

Ontology Terms

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Bibliography

  1. Raza S, Robertson KA, Lacaze PA, Page D, Enright AJ, Ghazal P, Freeman TC; ''A logic-based diagram of signalling pathways central to macrophage activation.''; BMC Syst Biol, 2008 PubMed

History

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RevisionActionTimeUserComment
71168view 03:58, 11 October 2013Mkutmonfixed unconnected lines
68919view 10:32, 8 July 2013MaintBotUpdated to 2013 gpml schema
67733view 04:56, 26 June 2013DdiglesOntology Term : 'Type II interferon signaling pathway' added !
45027view 11:45, 6 October 2011KhanspersOntology Term : 'Jak-Stat signaling pathway' added !
41066view 16:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
32475view 10:32, 15 August 2009MaintBotFixed text labels
32169view 07:07, 14 August 2009MaintBotFixed group labels
28124view 07:23, 27 January 2009Thomaschanged title
28061view 05:16, 23 January 2009Thomas
28060view 05:16, 23 January 2009ThomasNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
(ISGF3)GeneProduct10379 (Entrez Gene)
CIITAGeneProduct4261 (Entrez Gene)
CXCL10GeneProduct3627 (Entrez Gene)
CXCL9GeneProduct4283 (Entrez Gene)
CYBBGeneProduct1536 (Entrez Gene)
EIF2AK2GeneProduct5610 (Entrez Gene)
G1P2GeneProduct9636 (Entrez Gene)
G1P3GeneProduct2537 (Entrez Gene)
GBP1GeneProduct2633 (Entrez Gene)
HIST2H4GeneProduct8370 (Entrez Gene)
HLA-BGeneProduct3106 (Entrez Gene)
ICAM1GeneProduct3383 (Entrez Gene)
IFIT2GeneProduct3433 (Entrez Gene)
IFNAGeneProduct3440 (Entrez Gene)
IFNB1GeneProduct3456 (Entrez Gene)
IFNGGeneProduct3458 (Entrez Gene)
IFNGR1GeneProduct3459 (Entrez Gene)
IFNGR2GeneProduct3460 (Entrez Gene)
IL1BGeneProduct3553 (Entrez Gene)
IRF1GeneProduct3659 (Entrez Gene)
IRF2GeneProduct3660 (Entrez Gene)
IRF4GeneProduct3662 (Entrez Gene)
IRF8 [P]GeneProduct3394 (Entrez Gene)
IRF8GeneProduct3394 (Entrez Gene)
IRF9GeneProduct10379 (Entrez Gene)
JAK1GeneProduct3716 (Entrez Gene)
JAK2GeneProduct3717 (Entrez Gene)
NOS2AGeneProduct4843 (Entrez Gene)
OAS1GeneProduct4938 (Entrez Gene)
PRKCDGeneProduct5580 (Entrez Gene)
PSMB9GeneProduct5698 (Entrez Gene)
PTPGeneProduct5967 (Entrez Gene)
PTPN11GeneProduct5781 (Entrez Gene)
SOCS1GeneProduct8651 (Entrez Gene)
SOCS3GeneProduct9021 (Entrez Gene)
SPI1GeneProduct6688 (Entrez Gene)
STAT1 [P]GeneProduct6772 (Entrez Gene)
STAT1GeneProduct6772 (Entrez Gene)
STAT2 [P]GeneProduct6773 (Entrez Gene)
STAT2GeneProduct6773 (Entrez Gene)
TAP1GeneProduct6890 (Entrez Gene)

Annotated Interactions

<cite>No annotated interactions</cite>