Interferon type I signaling pathways (Homo sapiens)

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Type I IFNs CREB TRANSLATION INITIATION ISGF3 complex STAT1 STAT2 IRF9 P P GAF complex STAT1 STAT1 P P STAT4 STAT4 STAT2 PI3K complex PIK3R1 PIK3CD PIK3R2 P mTORC1 GAS Gamma Activated Sequence ISRE Interferon Stimulated Response Element IFNAR2b STAT3 STAT3 Negative regulators of IFN transcription Negative regulators of IFN signaling Type I IFN Receptor Complex IFNAR1 IFNAR2c TYK2 JAK1 IFNAR2a SOCS1 PIAS1 PTPN6 PTPN11 SOCS3 Rac1 CBL CRKL RAPGEF1 RAP1A CrkL STAT5 IRS1 IRS2 FRAP1 PTPRC Lck Zap70 PIAS3 GAB2 GNB2L1 GDP GTP MLST8 RPTOR EIF4E MTOR PDCD4 EIF4B EIF4A1 REL MAPKAP1 PRMT1 FYN CRK MAPK14 P MAP2K3 P MAP2K6 P MAP3K1 P RPS6KA5 P RPS6KA4 P CREB1 P VAV1 P EIF4EBP1 P RPS6KB1 P RPS6 P Rac1 NFkB STAT1 STAT3 STAT3 STAT1 STAT2 P P P P P P P Trans-Signalling Name: Interferon type I signaling pathways License: CC BY 2.0 Organism: Homo sapiens


Description

The type I IFNs (IFNα family, IFNβ, IFNω, IFNε and IFNκ) all bind to and signal via the type I IFN receptor complex. The type I receptor consists of two main IFNAR1, IFNAR2c receptor chains and other accessory proteins. The pathway above (WP585) describes the Type I Interferon signaling pathways and shows both classical IFN signaling via the JAK-STAT pathway (dark lines) and other non-canonical IFN signaling pathways.

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Ontology Terms

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Bibliography

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History

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RevisionActionTimeUserComment
94686view 15:41, 4 October 2017Khanspersremoved old empty comment
85198view 00:54, 25 April 2016EgonwReplaced a mim-conversion with Arrow.
85043view 02:23, 10 April 2016EgonwReplaced a mim-conversion with mim-stimulation.
80201view 11:55, 22 May 2015Khanspersremoved miRNA targeting for PDCD4
80161view 14:11, 14 May 2015KhanspersAdded mir499a targeting of PDCD4
80148view 11:08, 14 May 2015KhanspersAdded mir21 interaction with PDCD4 and lit ref
79096view 08:26, 2 March 2015Sham.ukcolour
79095view 08:06, 2 March 2015Sham.ukadded trans-signaling via soluble IFN receptors
78499view 03:28, 7 January 2015MaintBotadded missing graphIds
73488view 16:00, 29 January 2014KhanspersModified title
70094view 11:35, 12 July 2013MaintBotupdating to 2013 schema
58437view 03:47, 13 February 2013Sham.ukSpecify description
58436view 03:45, 13 February 2013Sham.ukSpecify description
58435view 03:42, 13 February 2013Sham.ukPeriodical save, work in progress
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47017view 11:44, 11 March 2012Sham.ukModified description
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External references

DataNodes

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NameTypeDatabase referenceComment
CBLProtein867 (Entrez Gene)
CREB1Protein1385 (Entrez Gene)
CRKGeneProduct1398 (Entrez Gene)
CRKLProtein1399 (Entrez Gene)
CrkLProtein1399 (Entrez Gene)
EIF4A1Protein1973 (Entrez Gene)
EIF4BProtein1975 (Entrez Gene)
EIF4EProtein1977 (Entrez Gene)
EIF4EBP1Protein1978 (Entrez Gene)
FRAP1Protein2475 (Entrez Gene)
  • AKT
  • Type your comment here
FYNGeneProduct2534 (Entrez Gene)
GAB2Protein9846 (Entrez Gene)
GDPMetabolite17552 (ChEBI)
GNB2L1Protein10399 (Entrez Gene)RACK1
GTPMetabolite15996 (ChEBI)
IFNAR1Protein3454 (Entrez Gene)INTERFERON RECEPTOR
IFNAR2aProtein3455 (Entrez Gene)
IFNAR2bProtein3455 (Entrez Gene)
IFNAR2cProtein3455 (Entrez Gene)INTERFERON RECEPTOR
IRF9Protein10379 (Entrez Gene)
IRS1Protein3667 (Entrez Gene)
IRS2Protein8660 (Entrez Gene)
JAK1GeneProduct3716 (Entrez Gene)
LckGeneProduct3932 (Entrez Gene)
MAP2K3Protein5606 (Entrez Gene)
MAP2K6Protein5608 (Entrez Gene)
MAP3K1Protein4214 (Entrez Gene)
MAPK14Protein1432 (Entrez Gene)
MAPKAP1Protein79109 (Entrez Gene)
MLST8Protein64223 (Entrez Gene)
MTORProtein2475 (Entrez Gene)
PDCD4Protein27250 (Entrez Gene)
PIAS1GeneProduct8554 (Entrez Gene)
PIAS3GeneProduct10401 (Entrez Gene)
PIK3CDProtein5293 (Entrez Gene)
PIK3R1Protein5295 (Entrez Gene)
PIK3R2Protein5296 (Entrez Gene)
PRMT1Protein3276 (Entrez Gene)
PTPN11GeneProduct5781 (Entrez Gene)SHP2
PTPN6GeneProduct5777 (Entrez Gene)SHP1
PTPRCGeneProduct5788 (Entrez Gene)CD45
RAP1AProtein5906 (Entrez Gene)
RAPGEF1Protein2889 (Entrez Gene)C3G
RELProtein5966 (Entrez Gene)
RPS6Protein6194 (Entrez Gene)
RPS6KA4Protein8986 (Entrez Gene)
RPS6KA5Protein9252 (Entrez Gene)
RPS6KB1Protein6198 (Entrez Gene)
RPTORProtein57521 (Entrez Gene)
Rac1Protein5879 (Entrez Gene)
SOCS1Protein8651 (Entrez Gene)
SOCS3Protein9021 (Entrez Gene)
STAT1Protein6772 (Entrez Gene)
STAT2Protein6773 (Entrez Gene)
STAT3Protein6774 (Entrez Gene)
STAT4Protein6775 (Entrez Gene)
STAT5Protein6776 (Entrez Gene)
TYK2Protein7297 (Entrez Gene)
VAV1Protein7409 (Entrez Gene)
Zap70GeneProduct7535 (Entrez Gene)

Annotated Interactions

<cite>No annotated interactions</cite>