TGF-beta Receptor Signaling (Homo sapiens)

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Repressors R-Smads DNA Co-Smads Cofactor Accessory receptor Rsmads Cofactors Co-smads Ligands TGFBR3 ZFHX1B JAK1 MAPK9 RUNX2 SMAD4 BMP4 TNF FST SPP1 WNT1 TGFBR2 THBS1 LIF NOG LEF1 ENG SMAD6 BMP4 ZNF423 MAPK3 RUNX3 NFKB1 EP300 SERPINE1 SMAD1 LTBP1 STAT3 MIR302A ZFYVE9 IFNG TGFB1 JUN SMAD2 SMAD7 FOXH1 HRAS CTNNB1 TNF FOS TFE3 EGF STAT1 CREBBP TGFBR1 ITGB6 TGIF SKI SKIL FKBP1A BAMBI SMAD9 SMAD1 SMAD3 SMAD2 SMAD5 TGFBR1 TGFBR2 TGFB1 INHBA LEFTY1 LEFTY2 Name: TGF-beta Receptor Signaling License: CC BY 2.0 Last Modified: 2/21/2013 Organism: Homo sapiens


The Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. In spite of the wide range of cellular processes that the TGFβ signaling pathway regulates, the process is relatively simple. TGFβ superfamily ligands bind to a type II receptor, which recruits and phosphorylates a type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD SMAD4. R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression. (source: WikiPedia).

Also see: TGF-beta receptor signaling at the NCI-Nature pathway interaction database.

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Ontology Terms



  1. Massague J, Blain SW, Lo RS; ''TGFbeta signaling in growth control, cancer, and heritable disorders.''; Cell, 2000 PubMed
  2. Massague J; ''How cells read TGF-beta signals.''; Nat Rev Mol Cell Biol, 2000 PubMed
  3. Ivey KN, Srivastava D; ''MicroRNAs as regulators of differentiation and cell fate decisions.''; Cell Stem Cell, 2010 PubMed


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94936view 09:30, 15 October 2017Khanspersremoved unconnected anchor
94820view 19:53, 5 October 2017Khanspersconnected interactions
90187view 12:45, 21 October 2016Khanspersfixed unconnected
86085view 13:48, 29 June 2016AlexanderPicoRemoved extraneous comment from legacy version
83868view 17:52, 17 December 2015AlexanderPicoModified title
68944view 10:35, 8 July 2013MaintBotUpdated to 2013 gpml schema
59137view 15:37, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
45086view 13:56, 6 October 2011KhanspersOntology Term : 'transforming growth factor-beta superfamily mediated signaling pathway' added !
42992view 11:28, 25 May 2011Samuel SklarLitref added
42596view 14:38, 7 April 2011Samuel SklarSpecify description
42595view 14:25, 7 April 2011Samuel SklarSpecify description
42594view 14:08, 7 April 2011Samuel SklarPeriodical save, work in progress
41094view 16:21, 1 March 2011MaintBotRemoved redundant pathway information and comments
38767view 16:29, 23 September 2010AlexanderPico
38766view 16:28, 23 September 2010AlexanderPicoSpecify description
38765view 16:24, 23 September 2010AlexanderPicobeautification
32150view 07:01, 14 August 2009MaintBotFixed group labels
30273view 13:30, 25 July 2009AlexanderPicofixed unsupported characters in bibliography
21858view 04:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:TGF Beta Signaling Pathway]] moved to [[Pathway:WP560]]: Moved to stable identifier
14923view 08:10, 24 May 2008MartijnVanIerselPeriodical save, work in progress
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11728view 13:24, 23 April 2008AlexanderPicoModified description
11726view 13:23, 23 April 2008AlexanderPicoModified description
11720view 08:33, 23 April 2008Thomastransfered references in GenMAPP comment to literature references
11718view 08:29, 23 April 2008ThomasModified description
8440view 06:46, 7 January 2008MaintBot[[Pathway:Human:TGF Beta Signaling Pathway]] moved to [[Pathway:Homo sapiens:TGF Beta Signaling Pathway]]: Renaming species
7836view 09:21, 18 December 2007MaintBotfixed category names
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6398view 15:18, 22 May 2007N.Galgpml file for [[Human:TGF_Beta_Signaling_Pathway]]

External references


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NameTypeDatabase referenceComment
BAMBIGeneProduct25805 (Entrez Gene)
BMP4GeneProduct652 (Entrez Gene)
CREBBPGeneProduct1387 (Entrez Gene)
CTNNB1GeneProduct1499 (Entrez Gene)
EGFGeneProduct1950 (Entrez Gene)
ENGGeneProduct2022 (Entrez Gene)
EP300GeneProduct2033 (Entrez Gene)
FKBP1AGeneProduct2280 (Entrez Gene)
FOSGeneProduct2353 (Entrez Gene)
FOXH1GeneProduct8928 (Entrez Gene)
FSTGeneProduct10468 (Entrez Gene)
HRASGeneProduct3265 (Entrez Gene)
IFNGGeneProduct3458 (Entrez Gene)
INHBAGeneProduct3624 (Entrez Gene)
ITGB6GeneProduct3694 (Entrez Gene)
JAK1GeneProduct3716 (Entrez Gene)
JUNGeneProduct3725 (Entrez Gene)
LEF1GeneProduct51176 (Entrez Gene)
LEFTY1GeneProduct10637 (Entrez Gene)
LEFTY2GeneProduct7044 (Entrez Gene)
LIFGeneProduct3976 (Entrez Gene)
LTBP1GeneProduct4052 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MAPK9GeneProduct5601 (Entrez Gene)
MIR302AGeneProductENSG00000207927 (Ensembl)
NFKB1GeneProduct4790 (Entrez Gene)
NOGGeneProduct9241 (Entrez Gene)
RUNX2GeneProduct860 (Entrez Gene)
RUNX3GeneProduct864 (Entrez Gene)
SERPINE1GeneProduct5054 (Entrez Gene)
SKIGeneProduct6497 (Entrez Gene)
SKILGeneProduct6498 (Entrez Gene)
SMAD1GeneProduct4086 (Entrez Gene)
SMAD2GeneProduct4087 (Entrez Gene)
SMAD3GeneProduct4088 (Entrez Gene)
SMAD4GeneProduct4089 (Entrez Gene)
SMAD5GeneProduct4090 (Entrez Gene)
SMAD6GeneProduct4091 (Entrez Gene)
SMAD7GeneProduct4092 (Entrez Gene)
SMAD9GeneProduct4093 (Entrez Gene)
SPP1GeneProduct6696 (Entrez Gene)
STAT1GeneProduct6772 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
TFE3GeneProduct7030 (Entrez Gene)
TGFB1GeneProduct7040 (Entrez Gene)
TGFBR1GeneProduct7046 (Entrez Gene)
TGFBR2GeneProduct7048 (Entrez Gene)
TGFBR3GeneProduct7049 (Entrez Gene)
TGIFGeneProduct7050 (Entrez Gene)
THBS1GeneProduct7057 (Entrez Gene)there are 5 types of tsp
TNFGeneProduct7124 (Entrez Gene)
WNT1GeneProduct7471 (Entrez Gene)
ZFHX1BGeneProduct9839 (Entrez Gene)
ZFYVE9GeneProduct9372 (Entrez Gene)
ZNF423GeneProduct23090 (Entrez Gene)

Annotated Interactions

<cite>No annotated interactions</cite>