Cytokines and Inflammatory Response (Homo sapiens)

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Hematopoietic Stem Cell Tc Neutrophil MHC II Hypothalamus (fever) Th antibodies TCR Eos Plasma Cell Tc antigen Eos Mast Cell Macrophage T-helper B Cell Hematopoiesis Clonal expansion of T cells B Cell Tc Lymphocyte Activated Killer Cells (LAK) Endothelial Cells T-helper Th B Cell B Cell Th Fibroblasts NK cell Eos IL1B CD4 IL1A Inflammatory Response TNF IL2 IL2 IL6 IL2 IL1B IL6 IL1A TGFB1 TNF IL4 IL2 HLA-DRA HLA-DRB1 IL2 IL15 IFNG IL10 IL3 IL4 IL3 IL5 TRA TRB TGFB1 PDGFA CSF1 CSF3 CSF2 TNF IL12B IL11 IL1B IL1A IL6 IL12B IL15 IL2 IL10 IL4 IL3 IFNG IFN1@ TNF IL13 CXCL2 TNF IL3 IL7 IL6 CSF2 IL10 IL4 IFN1@ IL1A IL15 CXCL1 IL6 IL12 IL10 IFNB1 IL1B TNF IL1A TNF IL1B TGFB1 IL13 IFNG IL5 IL4 IL2 Name: Cytokines and Inflammatory Response License: CC BY 2.0 Organism: Homo sapiens


Inflammation is a protective response to infection by the immune system that requires communication between different classes of immune cells to coordinate their actions. Acute inflammation is an important part of the immune response, but chronic inappropriate inflammation can lead to destruction of tissues in autoimmune disorders and perhaps neurodegenerative or cardiovascular disease. Secreted cytokine proteins provide signals between immune cells to coordinate the inflammatory response. Sources: BioCarta.

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Ontology Terms



  1. Kataoka T; ''Chemical biology of inflammatory cytokine signaling.''; J Antibiot (Tokyo), 2009 PubMed


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96982view 11:22, 24 April 2018AlexanderPicoReverted to version '16:45, 12 October 2017' by AlexanderPico
96975view 08:49, 24 April 2018WpblockedModified title
94907view 16:45, 12 October 2017Khanspersconnected interactions
94763view 08:53, 5 October 2017Ryanmillerconnected unconnected lines
79331view 04:46, 21 March 2015EgonwOh, it contained more gene names as identifiers. Also fixed now.
79328view 04:19, 21 March 2015EgonwReplaced a gene name with its Entrez Gene identifier.
63173view 13:28, 8 May 2013MaintBotUpdating gpml version
53161view 01:08, 30 October 2012Jack007Periodical save, work in progress
53160view 00:51, 30 October 2012Jack007box enlarge
41163view 16:41, 1 March 2011MaintBotRemoved redundant pathway information and comments
40019view 19:30, 25 January 2011AlexanderPicoModified description
39750view 23:37, 16 January 2011AlexanderPico
38645view 05:16, 23 September 2010FerryJagersLinked Inflammatory Response pathway
38185view 15:54, 23 August 2010AlexanderPicoModified description
35247view 12:54, 11 February 2010Thomasadded literature
32459view 10:25, 15 August 2009MaintBotFixed text labels
32142view 06:58, 14 August 2009MaintBotFixed group labels
21794view 04:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:Cytokines and Inflammatory Response Biocarta]] moved to [[Pathway:WP530]]: Moved to stable identifier
15005view 14:26, 24 May 2008AlexanderPicoGrouped, labeled and connected!
15002view 14:24, 24 May 2008AlexanderPicoPeriodical save, work in progress
15000view 14:14, 24 May 2008AlexanderPicoPeriodical save, work in progress
14998view 14:04, 24 May 2008AlexanderPicoPeriodical save, work in progress
14993view 13:54, 24 May 2008AlexanderPicoPeriodical save, work in progress
14991view 13:44, 24 May 2008AlexanderPicoPeriodical save, work in progress
14989view 13:33, 24 May 2008AlexanderPicoPeriodical save, work in progress
14553view 22:21, 22 May 2008AlexanderPicoModified description
12934view 03:41, 17 May 2008MaintBotSticky edges patch by Sjoerd
7978view 06:46, 7 January 2008MaintBot[[Pathway:Human:Cytokines and Inflammatory Response Biocarta]] moved to [[Pathway:Homo sapiens:Cytokines and Inflammatory Response Biocarta]]: Renaming species
7613view 09:04, 18 December 2007MaintBotfixed category names
7470view 05:42, 4 November 2007MaintBotAdded categories to GPML
6306view 15:17, 22 May 2007S.Burelgpml file for [[Human:Cytokines_and_Inflammatory_Response_Biocarta]]

External references


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NameTypeDatabase referenceComment
Inflammatory ResponsePathwayWP453 (WikiPathways)
CD4GeneProduct920 (Entrez Gene)
CSF1GeneProduct1435 (Entrez Gene)
CSF2GeneProduct1437 (Entrez Gene)
CSF3GeneProduct1440 (Entrez Gene)
CXCL1GeneProduct2919 (Entrez Gene)
CXCL2GeneProduct2920 (Entrez Gene)
HLA-DRAGeneProduct3122 (Entrez Gene)
HLA-DRB1GeneProduct3123 (Entrez Gene)
IFN1@GeneProduct3438 (Entrez Gene)
IFNB1GeneProduct3456 (Entrez Gene)
IFNGGeneProduct3458 (Entrez Gene)
IL10GeneProduct3586 (Entrez Gene)
IL11GeneProduct3589 (Entrez Gene)
IL12GeneProduct3593 (Entrez Gene)
IL12BGeneProduct3593 (Entrez Gene)
IL13GeneProduct3596 (Entrez Gene)
IL15GeneProduct3600 (Entrez Gene)
IL1AGeneProduct3552 (Entrez Gene)
IL1BGeneProduct3553 (Entrez Gene)
IL2GeneProduct3558 (Entrez Gene)
IL3GeneProduct16187 (Entrez Gene)
IL3GeneProduct3562 (Entrez Gene)
IL4GeneProduct3565 (Entrez Gene)
IL5GeneProduct3567 (Entrez Gene)
IL6GeneProduct3569 (Entrez Gene)
IL7GeneProduct3574 (Entrez Gene)
PDGFAGeneProduct5154 (Entrez Gene)
TGFB1GeneProduct7040 (Entrez Gene)
TNFGeneProduct7124 (Entrez Gene)
TRAGeneProduct6955 (Entrez Gene)
TRBGeneProduct6957 (Entrez Gene)

Annotated Interactions

<cite>No annotated interactions</cite>