Acetylcholine Synthesis (Homo sapiens)

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*Cytosol* *Synaptic Cleft* PEMT PCYT1A CHKA ACHE CHAT Glycerophosphocholine Choline Acetyl CoA Acetate Choline Phosphorylcholine Acetylcholine Phosphatidylethanolamine Pyruvate from Glycolysis Phosphatidylcholine Cytidine diphosphate choline PDHA1 PDHA2 Name: Acetylcholine Synthesis Organism: Homo sapiens


Acetylcholine is an important neurotransmitter. It can be rapidly released in the synaptic cleft upon activation of the neuron. In the synaptic cleft the compound is degraded rapidly into choline and acetate, this is essential for proper neuronal functioning. Choline and Acetate are taken up into the cytosol and recycled for the next activation.

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Ontology Terms



  1. Blusztajn JK, Wurtman RJ; ''Choline and cholinergic neurons.''; Science, 1983 PubMed


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79855view 07:00, 20 April 2015Mkutmonconversion of choline to phosphorylcholine - should not start from the transport interaction
79212view 12:45, 12 March 2015KhanspersReverted to version '15:29, 6 October 2014' by Khanspers
79143view 22:36, 4 March 2015KhanspersAdded conversion comment
77669view 08:29, 6 October 2014Mkutmonfixed unconnected lines
76269view 11:15, 25 June 2014MaintBotconnected interactions, switched to mim-catalysis, added graphical lines
72538view 08:11, 19 November 2013EgonwWider boxes so that the full label is visible.
72530view 00:28, 19 November 2013AnweshaConnected Interactions
72513view 11:16, 18 November 2013AriuttaReverted to version '17:58, 8 July 2013' by Ariutta
72348view 18:06, 10 November 2013Ariutta
69052view 10:58, 8 July 2013EgonwReplaced an outdated HMDB identifier with the 3.5 one.
63138view 12:15, 8 May 2013MaintBotUpdating GPML version
44939view 05:28, 6 October 2011MartijnVanIerselOntology Term : 'acetylcholine metabolic pathway' added !
41084view 16:20, 1 March 2011MaintBotRemoved redundant pathway information and comments
38919view 14:06, 24 September 2010Khanspers
35059view 03:55, 11 February 2010Thomasadded literature reference
34458view 11:25, 10 December 2009MaintBotAutomatic update of empty xrefs
33205view 12:29, 5 November 2009KhanspersPeriodical save, work in progress
32140view 06:57, 14 August 2009MaintBotFixed group labels
29049view 06:05, 27 March 2009MartijnVanIerselModified description
29048view 05:57, 27 March 2009MartijnVanIerselFixed phosphorylcholine
29046view 05:54, 27 March 2009MartijnVanIerselMetabolized labels
21790view 04:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:Acetylcholine Synthesis]] moved to [[Pathway:WP528]]: Moved to stable identifier
16330view 05:19, 18 June 2008HubertModified description
15387view 15:20, 27 May 2008Khanspersconnectors
14388view 12:19, 22 May 2008KhanspersAdded connectors
14386view 12:02, 22 May 2008KhanspersPeriodical save, work in progress
14384view 11:52, 22 May 2008KhanspersPeriodical save, work in progress
13035view 04:10, 17 May 2008MaintBotautomated metabolite conversion
7878view 06:46, 7 January 2008MaintBot[[Pathway:Human:Acetylcholine Synthesis]] moved to [[Pathway:Homo sapiens:Acetylcholine Synthesis]]: Renaming species
7564view 09:00, 18 December 2007MaintBotfixed category names
7325view 05:42, 4 November 2007MaintBotAdded categories to GPML
6290view 15:17, 22 May 2007A.Kwatest

External references


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NameTypeDatabase referenceComment
ACHEGeneProduct43 (Entrez Gene)
AcetateMetabolite64-19-7 (CAS)
Acetyl CoAMetabolite72-89-9 (CAS)
AcetylcholineMetabolite51-84-3 (CAS)
CHATGeneProduct1103 (Entrez Gene)
CHKAGeneProduct1119 (Entrez Gene)
CholineMetabolite62-49-7 (CAS)
Cytidine diphosphate cholineMetaboliteHMDB01413 (HMDB)
GlycerophosphocholineMetabolite28319-77-9 (CAS)
PCYT1AGeneProduct5130 (Entrez Gene)
PDHA1GeneProduct5160 (Entrez Gene)
PDHA2GeneProduct5161 (Entrez Gene)
PEMTGeneProduct10400 (Entrez Gene)
PhosphatidylcholineMetaboliteHMDB00564 (HMDB)
PhosphatidylethanolamineMetaboliteHMDB60501 (HMDB)
PhosphorylcholineMetaboliteHMDB01565 (HMDB)
Pyruvate from GlycolysisMetaboliteHMDB00243 (HMDB)

Annotated Interactions

<cite>No annotated interactions</cite>