G1 to S cell cycle control (Homo sapiens)

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G2 Phase-M phase CDK1 CCNG2 CCNB1 CCNA1 G1 Phase Ubiquitin-mediated Degradation G1/S transition Phase G1/S Cell Cycle Checkpoint G1 Cyclin Dependant Cyclases DNA polymerases DNA replication phosphorylation of proteins involved in G1/S transition Cell cycle DNA replication genes Cyclin Ds G1/S transition Cyclin Dependent Kinases CDK2 Cyclin Es CCNE1 CCNE2 origin recognition complex ORC1L ORC3L ORC6L ORC2L ORC4L ORC5L PCNA CDC45L TP53 P MDM2 TP53 MYC ATM GADD45A CDC25A MCM4 MCM3 MCM6 MCM7 MCM2 CDC2A MCM5 CCND2 CCND3 CCND1 CDK2 CCNE1 CREB3L4 CREB3 CREB3L3 CREBL1 CREB1 CREB3L1 MYT1 WEE1 CDKN1B CDKN1A CDKN1C P CDK2 CCNE1 TFDP2 TFDP1 POLE POLE2 POLA2 PRIM2A PRIM1 RPA2 RPA3 RPA1 CDKN2A CDKN2B CDKN2D CDKN2C CDK6 CDK4 CDK7 P RB1 E2F2 E2F1 E2F3 CDK7 CCNH MNAT1 CDK4 CDK6 CCND1 CDK4 CDK6 CCND1 CDK4 CDK6 P RB1 E2F2 E2F1 E2F3 TFDP2 TFDP1 Name: G1 to S cell cycle control License: CC BY 2.0 Last Modified: 10/17/2013 Organism: Homo sapiens


In the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding CKIs mediated by the p53 protein, whereas the p53-independent mechanisms inhibit CDKs through the inhibitory T14Y15 phosphorylation of Cdk2. Failure of DNA damage checkpoints in G1 leads to mutagenic replication of damaged templates and other replication defects.

Source: Reactome http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&FOCUS_SPECIES=Homo%20sapiens&ID=69615&

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Ontology Terms



  1. Maeda T, Hanna AN, Sim AB, Chua PP, Chong MT, Tron VA; ''GADD45 regulates G2/M arrest, DNA repair, and cell death in keratinocytes following ultraviolet exposure.''; J Invest Dermatol, 2002 PubMed


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97000view 15:11, 25 April 2018Khanspersadded phosphosites, general cleanup
95145view 20:02, 16 November 2017AlexanderPicoconnected interactions
95124view 08:09, 16 November 2017DeSlFixed nested groups
94764view 09:01, 5 October 2017Ryanmillerconnected lines
80001view 01:36, 30 April 2015Zarichanged Box for CyclinD an CdK , annotated CDC2A gene
80000view 01:21, 30 April 2015ZariChanged box for CyclinD and CdK
71377view 11:39, 17 October 2013MaintBotAutomated update of data sources
67270view 03:29, 26 June 2013Christine ChichesterOntology Term : 'G1/S DNA damage checkpoint pathway' added !
63189view 13:50, 8 May 2013MaintBotUpdating gpml version
45301view 12:58, 7 October 2011AlexanderPicoOntology Term : 'cell cycle checkpoint pathway' added !
41128view 16:38, 1 March 2011MaintBotRemoved redundant pathway information and comments
38746view 15:18, 23 September 2010Mark.scottccna1 link
38745view 15:17, 23 September 2010Mark.scottconnect cdk1
35815view 12:02, 17 February 2010KhanspersModified description
35814view 11:36, 17 February 2010KhanspersAdded lit ref
32435view 10:14, 15 August 2009MaintBotFixed text labels
32104view 06:46, 14 August 2009MaintBotFixed group labels
20771view 04:29, 14 November 2008MaintBot[[Pathway:Homo sapiens:Cell Cycle-G1 to S control Reactome]] moved to [[Pathway:WP45]]: Moved to stable identifier
15393view 15:27, 27 May 2008Khanspersconnectors
14438view 15:42, 22 May 2008KhanspersAdded connectors, groups
14433view 15:33, 22 May 2008KhanspersPeriodical save, work in progress
14427view 15:30, 22 May 2008KhanspersAdded connectors
14423view 15:23, 22 May 2008KhanspersPeriodical save, work in progress
14421view 15:12, 22 May 2008KhanspersAdded connectors
14407view 13:10, 22 May 2008KhanspersAdded connectors
12942view 03:43, 17 May 2008MaintBotSticky edges patch by Sjoerd
7944view 06:46, 7 January 2008MaintBot[[Pathway:Human:Cell Cycle-G1 to S control Reactome]] moved to [[Pathway:Homo sapiens:Cell Cycle-G1 to S control Reactome]]: Renaming species
7597view 09:03, 18 December 2007MaintBotfixed category names
7205view 05:33, 4 November 2007MaintBotAdded categories to GPML
6300view 15:17, 22 May 2007A.C.Zambongpml file for [[Human:Cell_Cycle-G1_to_S_control_Reactome]]

External references


View all...
NameTypeDatabase referenceComment
ATMGeneProduct472 (Entrez Gene)
CCNA1GeneProduct8900 (Entrez Gene)
CCNB1GeneProduct891 (Entrez Gene)
CCND1GeneProduct595 (Entrez Gene)
CCND2GeneProduct894 (Entrez Gene)
CCND3GeneProduct896 (Entrez Gene)
CCNE1GeneProduct898 (Entrez Gene)
CCNE2GeneProduct9134 (Entrez Gene)
CCNG2GeneProduct901 (Entrez Gene)
CCNHGeneProduct902 (Entrez Gene)
CDC25AGeneProduct993 (Entrez Gene)
CDC2AGeneProduct1017 (Entrez Gene)
CDC45LGeneProduct8318 (Entrez Gene)
CDK1GeneProduct983 (Entrez Gene)
CDK2GeneProduct1017 (Entrez Gene)
CDK2GeneProductENSG00000123374 (Ensembl)
CDK4GeneProduct1019 (Entrez Gene)
CDK6GeneProduct1021 (Entrez Gene)
CDK7GeneProduct1022 (Entrez Gene)
CDKN1AGeneProduct1026 (Entrez Gene)
CDKN1BGeneProduct1027 (Entrez Gene)
CDKN1CGeneProduct1028 (Entrez Gene)
CDKN2AGeneProduct1029 (Entrez Gene)
CDKN2BGeneProduct1030 (Entrez Gene)
CDKN2CGeneProduct1031 (Entrez Gene)
CDKN2DGeneProduct1032 (Entrez Gene)
CREB1GeneProduct1385 (Entrez Gene)
CREB3GeneProduct10488 (Entrez Gene)
CREB3L1GeneProduct90993 (Entrez Gene)
CREB3L3GeneProduct84699 (Entrez Gene)
CREB3L4GeneProduct148327 (Entrez Gene)
CREBL1GeneProduct1388 (Entrez Gene)
E2F1GeneProduct1869 (Entrez Gene)
E2F2GeneProduct1870 (Entrez Gene)
E2F3GeneProduct1871 (Entrez Gene)
GADD45AGeneProduct1647 (Entrez Gene)
MCM2GeneProduct4171 (Entrez Gene)
MCM3GeneProduct4172 (Entrez Gene)
MCM4GeneProduct4173 (Entrez Gene)
MCM5GeneProduct4174 (Entrez Gene)
MCM6GeneProduct4175 (Entrez Gene)
MCM7GeneProduct4176 (Entrez Gene)
MDM2GeneProduct4193 (Entrez Gene)
MNAT1GeneProduct4331 (Entrez Gene)
MYCGeneProduct4609 (Entrez Gene)
MYT1GeneProduct4661 (Entrez Gene)
ORC1LGeneProduct4998 (Entrez Gene)
ORC2LGeneProduct4999 (Entrez Gene)
ORC3LGeneProduct23595 (Entrez Gene)
ORC4LGeneProduct5000 (Entrez Gene)
ORC5LGeneProduct5001 (Entrez Gene)
ORC6LGeneProduct23594 (Entrez Gene)
PCNAGeneProduct5111 (Entrez Gene)
POLA2GeneProduct23649 (Entrez Gene)
POLE2GeneProduct5427 (Entrez Gene)
POLEGeneProduct5426 (Entrez Gene)
PRIM1GeneProduct5557 (Entrez Gene)
PRIM2AGeneProduct5558 (Entrez Gene)
RB1GeneProduct5925 (Entrez Gene)
RPA1GeneProduct6117 (Entrez Gene)
RPA2GeneProduct6118 (Entrez Gene)
RPA3GeneProduct6119 (Entrez Gene)
TFDP1GeneProduct7027 (Entrez Gene)
TFDP2GeneProduct7029 (Entrez Gene)
TP53GeneProduct7157 (Entrez Gene)
WEE1GeneProduct7465 (Entrez Gene)

Annotated Interactions

<cite>No annotated interactions</cite>