One Carbon Metabolism (Mus musculus)

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This one-carbon metabolism pathway is centered around folate. Folate is the primary methyl-group donor for processes such as DNA methylation reactions, nucleotide synthesis and DNA repair mechanisms. An important pathway for any study related to folate or DNA methylation.

Differential methylation (e.g. hypermethylation of tumor suppressors) as well as disturbances in nucleotide synthesis and repair, are associated with several forms of cancer. There are also indications that hypermethylation is involved in the progression of adenomas to cancer.

Inferred from human one-carbon metabolism pathway.

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Ontology Terms



  1. Hazra A, Wu K, Kraft P, Fuchs CS, Giovannucci EL, Hunter DJ; ''Twenty-four non-synonymous polymorphisms in the one-carbon metabolic pathway and risk of colorectal adenoma in the Nurses' Health Study''; Carcinogenesis 2007 Jul; 28(7) 1510-9., 2007 PubMed


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89673view 01:16, 24 September 2016EgonwReplaced the CAS for polyglutamate with the ChEBI ID for this metabolite.
71889view 02:59, 22 October 2013Mkutmonchanged Unknown datanodes to GeneProduct datanodes
69057view 11:07, 8 July 2013MaintBotUpdated to 2013 gpml schema
67551view 04:24, 26 June 2013DdiglesOntology Term : 'folate mediated one-carbon metabolic pathway' added !
42576view 16:31, 5 April 2011AlexanderPicotrying to fix glitch
41239view 17:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
34970view 17:42, 8 February 2010KhanspersReverted to version '22:41, 9 December 2009' by Khanspers
34969view 17:40, 8 February 2010KhanspersPeriodical save, work in progress
34369view 15:41, 9 December 2009MaintBotAutomatic update of empty xrefs
32996view 12:11, 30 September 2009MaintBotadded some connectors
32097view 06:44, 14 August 2009MaintBotFixed group labels
29220view 04:29, 15 April 2009EveloSpecify description
29219view 04:27, 15 April 2009Eveloongoing work
29189view 15:14, 9 April 2009EveloSmall updates
29188view 14:55, 9 April 2009EveloPeriodical save, work in progress
29180view 08:49, 9 April 2009EveloWork in progress
29179view 08:44, 9 April 2009EveloPeriodical save, work in progress
29178view 08:23, 9 April 2009EveloMore metabolites annotated
29177view 08:14, 9 April 2009EveloPeriodical save, work in progress
29176view 07:38, 9 April 2009EveloWork in progress
29175view 07:35, 9 April 2009EveloMetabolite annotations
29172view 07:18, 9 April 2009EveloPeriodical save, work in progress
21596view 04:32, 14 November 2008MaintBot[[Pathway:Mus musculus:One-carbon metabolism]] moved to [[Pathway:WP435]]: Moved to stable identifier
10150view 14:10, 14 January 2008AlexanderPicoadded category
10149view 13:04, 14 January 2008KhanspersAdded author, maintained by and email info
8310view 06:46, 7 January 2008MaintBot[[Pathway:Mouse:One-carbon metabolism]] moved to [[Pathway:Mus musculus:One-carbon metabolism]]: Renaming species
7558view 02:02, 18 December 2007MichielSpecify description
7557view 02:02, 18 December 2007MichielSpecify description
7556view 02:00, 18 December 2007MichielSpecify description
7555view 01:57, 18 December 2007MichielAdded description
7552view 16:02, 17 December 2007KhanspersAdded author, email and maintained by info
7535view 05:48, 19 November 2007Michiel
7531view 05:37, 19 November 2007MichielAdded Histone methyl transferases
7530view 03:12, 19 November 2007MichielCorrected FOLH1
7524view 10:24, 17 November 2007MichielConverted from Human pathway

External references


View all...
NameTypeDatabase referenceComment
10-Formyl TetrahydrofolateMetabolite2800-34-2 (CAS)
5,10-Methenyl TetrahydrofolateMetaboliteHMDB01354 (HMDB)
5,10-Methylene TetrahydrofolateMetabolite12071 (ChEBI)
5-Formiminotetrahydrofolic acidMetaboliteHMDB01534 (HMDB)
5-FormyltetrahydrofolateMetaboliteHMDB01562 (HMDB)
5-Methyl TetrahydrofolateMetabolite134-35-0 (CAS)
AHCYGeneProduct269378 (Entrez Gene)
ALDH1L1GeneProduct107747 (Entrez Gene)
AMTGeneProduct434437 (Entrez Gene)
ATICGeneProduct108147 (Entrez Gene)
BHMTGeneProduct12116 (Entrez Gene)
BetaineMetaboliteHMDB00043 (HMDB)
CobalaminMetaboliteHMDB02174 (HMDB)
DHFRGeneProduct13361 (Entrez Gene)
DNMT1GeneProduct13433 (Entrez Gene)
DNMT3aGeneProduct13435 (Entrez Gene)
DNMT3bGeneProduct13436 (Entrez Gene)
DihydrofolateMetabolite4033-27-6 (CAS)
EHMT1GeneProduct77683 (Entrez Gene)
EHMT2GeneProduct110147 (Entrez Gene)
EthanolMetaboliteHMDB00108 (HMDB)
FOLH1GeneProduct53320 (Entrez Gene)
FTCDGeneProduct14317 (Entrez Gene)
GARTGeneProduct14450 (Entrez Gene)
GlycineMetaboliteHMDB00123 (HMDB)
HomocysteineMetaboliteHMDB00742 (HMDB)
KIAA0828GeneProduct74340 (Entrez Gene)
L-MethionineMetaboliteHMDB00696 (HMDB)
L-SerineMetaboliteHMDB00187 (HMDB)
MAT1AGeneProduct11720 (Entrez Gene)
MAT2BGeneProduct108645 (Entrez Gene)
MTFMTGeneProduct69606 (Entrez Gene)
MTHFD1GeneProduct108156 (Entrez Gene)
MTHFD1LGeneProduct270685 (Entrez Gene)
MTHFD2GeneProduct17768 (Entrez Gene)
MTHFRGeneProduct17769 (Entrez Gene)
MTHFSGeneProduct107885 (Entrez Gene)
MTRGeneProduct238505 (Entrez Gene)
MTRRGeneProduct210009 (Entrez Gene)
MethylcobalaminMetaboliteHMDB02274 (HMDB)
MonoglutamateMetabolite59-30-3 (CAS)
PolyglutamateMetabolite25513-46-6 (CAS)
Riboflavin/Vitamin B2MetaboliteHMDB00244 (HMDB)
S-AdenosylhomocysteineMetaboliteHMDB00939 (HMDB)
S-AdenosylmethionineMetabolite15414 (ChEBI)
SHMT1GeneProduct20425 (Entrez Gene)
SHMT2GeneProduct108037 (Entrez Gene)
TCN IIGeneProduct21452 (Entrez Gene)
TYMSGeneProduct22171 (Entrez Gene)
TetrahydrofolateMetabolite135-16-0 (CAS)

Annotated Interactions

<cite>No annotated interactions</cite>