Metabolic reprogramming in colon cancer (Homo sapiens)

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Tumor cell Carbon source Nucleotide synthesis Cell Cycle Proliferation Warburg effect pH balance Nitrogen source NH3 Phosphoserine Oxidative phosphorylation IC glucose GOT2 lipids IMP glutamate PPAT KG Glycolysis PSAT1 G6PD 3PHP SLC1A5 Asparagine PYCR1 PYCR2 G6P F6P HK3 GPI TIGAR PFKL G3P F1,6P GAPDH 2PG 1,3BPG 3PG ALDOB PGK1 PGAM1 PKM2 PKLR PKM2 LDHA Lactate ENO1 Pyruvate PEP SLC16A3 Lactate Acetyl-CoA PDHA1 PDHB Malate OAA ACO2 SUCLG1 SDHB DLST IDH2 citrate FH fumarate MDH2 S-CoA IDH3A Acetyl-CoA ACLY FASN PSPH SHMT2 PAICS serine glycine GART S7P R5P 6PGA E4P Ri5P TALDO1 RPIA TKT PGD Amino acid synthesis Purine synthesis Lipids synthesis Pentose Phosphate Pathway TCA Cycle glutamine Glutathione ROS glutamine Proline Amino acid synthesis SLC2A1 Name: Metabolic reprogramming in colon cancer Organism: Homo sapiens


Description

Metabolic reprogramming in colon cancer

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Ontology Terms

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Bibliography

  1. Lambeth DO, Tews KN, Adkins S, Frohlich D, Milavetz BI; ''Expression of two succinyl-CoA synthetases with different nucleotide specificities in mammalian tissues.''; J Biol Chem, 2004 PubMed
  2. Krebs HA, Holzach O; ''The conversion of citrate into cis-aconitate and isocitrate in the presence of aconitase.''; Biochem J, 1952 PubMed
  3. Comte B, Vincent G, Bouchard B, Benderdour M, Des Rosiers C; ''Reverse flux through cardiac NADP(+)-isocitrate dehydrogenase under normoxia and ischemia.''; Am J Physiol Heart Circ Physiol, 2002 PubMed
  4. Sheu KF, Blass JP; ''The alpha-ketoglutarate dehydrogenase complex.''; Ann N Y Acad Sci, 1999 PubMed
  5. Des Rosiers C, Fernandez CA, David F, Brunengraber H; ''Reversibility of the mitochondrial isocitrate dehydrogenase reaction in the perfused rat liver. Evidence from isotopomer analysis of citric acid cycle intermediates.''; J Biol Chem, 1994 PubMed
  6. Hoek JB, Rydström J; ''Physiological roles of nicotinamide nucleotide transhydrogenase.''; Biochem J, 1988 PubMed
  7. Sazanov LA, Jackson JB; ''Proton-translocating transhydrogenase and NAD- and NADP-linked isocitrate dehydrogenases operate in a substrate cycle which contributes to fine regulation of the tricarboxylic acid cycle activity in mitochondria.''; FEBS Lett, 1994 PubMed
  8. Fernandez CA, Des Rosiers C; ''Modeling of liver citric acid cycle and gluconeogenesis based on 13C mass isotopomer distribution analysis of intermediates.''; J Biol Chem, 1995 PubMed
  9. Lawson AM, Chalmers RA, Watts RW; ''Urinary organic acids in man. I. Normal patterns.''; Clin Chem, 1976 PubMed
  10. Gabriel JL, Zervos PR, Plaut GW; ''Activity of purified NAD-specific isocitrate dehydrogenase at modulator and substrate concentrations approximating conditions in mitochondria.''; Metabolism, 1986 PubMed
  11. Des Rosiers C, Di Donato L, Comte B, Laplante A, Marcoux C, David F, Fernandez CA, Brunengraber H; ''Isotopomer analysis of citric acid cycle and gluconeogenesis in rat liver. Reversibility of isocitrate dehydrogenase and involvement of ATP-citrate lyase in gluconeogenesis.''; J Biol Chem, 1995 PubMed
  12. Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen YC, Cox JE, Cardon CM, Van Vranken JG, Dephoure N, Redin C, Boudina S, Gygi SP, Brivet M, Thummel CS, Rutter J; ''A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans.''; Science, 2012 PubMed
  13. Greksák M, Lopes-Cardozo M, van den Bergh SG; ''Citrate synthesis in intact rat-liver mitochondria is irreversible.''; Eur J Biochem, 1982 PubMed
  14. Johnson JD, Muhonen WW, Lambeth DO; ''Characterization of the ATP- and GTP-specific succinyl-CoA synthetases in pigeon. The enzymes incorporate the same alpha-subunit.''; J Biol Chem, 1998 PubMed
  15. Liu TC, Kim H, Arizmendi C, Kitano A, Patel MS; ''Identification of two missense mutations in a dihydrolipoamide dehydrogenase-deficient patient.''; Proc Natl Acad Sci U S A, 1993 PubMed
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History

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RevisionActionTimeUserComment
97421view 04:49, 16 May 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
97411view 11:51, 15 May 2018KhanspersModified title
97409view 11:43, 15 May 2018KhanspersOntology Term : 'colorectal cancer' added !
97408view 11:43, 15 May 2018KhanspersOntology Term : 'cancer pathway' added !
97407view 11:43, 15 May 2018KhanspersOntology Term : 'altered carbohydrate metabolic pathway' added !
97406view 11:42, 15 May 2018KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1,3BPGMetaboliteHMDB01270 (HMDB)
2PGMetaboliteHMDB00362 (HMDB)
3PGMetaboliteHMDB00807 (HMDB)
3PHPMetaboliteCHEBI:18110 (ChEBI)
6PGAMetaboliteHMDB01316 (HMDB)
ACLYGeneProductENSG00000131473 (Ensembl)
ACO2GeneProduct50 (Entrez Gene)
ALDOBGeneProduct229 (Entrez Gene)
Acetyl-CoAMetaboliteHMDB01206 (HMDB)
AsparagineMetaboliteCHEBI:50347 (ChEBI)
DLSTGeneProduct1743 (Entrez Gene)
E4PMetaboliteHMDB01321 (HMDB)
ENO1GeneProduct2023 (Entrez Gene)
F1,6PMetaboliteHMDB01058 (HMDB)
F6PMetaboliteCHEBI:16084 (ChEBI)
FASNGeneProductENSG00000169710 (Ensembl)
FHGeneProduct2271 (Entrez Gene)
G3PMetaboliteHMDB01112 (HMDB)
G6PMetaboliteCHEBI:4170 (ChEBI)
G6PDGeneProductENSG00000160211 (Ensembl)
GAPDHGeneProductENSG00000111640 (Ensembl)
GARTGeneProductENSG00000159131 (Ensembl)
GOT2GeneProductENSG00000125166 (Ensembl)
GPIGeneProductENSG00000105220 (Ensembl)
GlutathioneMetaboliteCHEBI:16856 (ChEBI)
GlycolysisPathway
HK3GeneProductENSG00000160883 (Ensembl)
ICMetaboliteCHEBI:16087 (ChEBI)
IDH2GeneProduct3418 (Entrez Gene)
IDH3AGeneProduct3419 (Entrez Gene)
IMPMetaboliteCHEBI:17202 (ChEBI)
KGMetaboliteCHEBI:16810 (ChEBI)
LDHAGeneProduct3939 (Entrez Gene)
LactateMetaboliteHMDB00190 (HMDB)
MDH2GeneProduct4191 (Entrez Gene)
MalateMetaboliteHMDB00744 (HMDB)
NH3MetaboliteCHEBI:16134 (ChEBI)
OAAMetaboliteHMDB00223 (HMDB)
Oxidative phosphorylationPathwayWP623 (WikiPathways)
PAICSGeneProductENSG00000128050 (Ensembl)
PDHA1GeneProduct5160 (Entrez Gene)
PDHBGeneProduct5162 (Entrez Gene)
PEPMetaboliteHMDB00263 (HMDB)
PFKLGeneProductENSG00000141959 (Ensembl)
PGAM1GeneProduct5223 (Entrez Gene)
PGDGeneProduct5226 (Entrez Gene)
PGK1GeneProduct5230 (Entrez Gene)
PKLRGeneProduct5313 (Entrez Gene)
PKM2GeneProduct5315 (Entrez Gene)
PPATGeneProductENSG00000128059 (Ensembl)
PSAT1GeneProductENSG00000135069 (Ensembl)
PSPHGeneProductENSG00000146733 (Ensembl)
PYCR1GeneProductENSG00000183010 (Ensembl)
PYCR2GeneProductENSG00000143811 (Ensembl)
Pentose Phosphate PathwayPathway
PhosphoserineMetaboliteCHEBI:45522 (ChEBI)
ProlineMetaboliteCHEBI:26271 (ChEBI)
PyruvateMetaboliteHMDB00243 (HMDB)
R5PMetabolite3615-55-2 (CAS)
ROSMetaboliteQ424361 (Wikidata)
RPIAGeneProduct22934 (Entrez Gene)
Ri5PMetabolite4151-19-3 (CAS)
S-CoAMetaboliteHMDB01022 (HMDB)The ChEBI ID with the correct charge is: 57292
S7PMetabolite2646-35-7 (CAS)
SDHBGeneProduct6390 (Entrez Gene)
SHMT2GeneProductENSG00000182199 (Ensembl)
SLC16A3GeneProductENSG00000141526 (Ensembl)
SLC1A5GeneProductENSG00000105281 (Ensembl)
SLC2A1GeneProductENSG00000117394 (Ensembl)
SUCLG1GeneProduct8802 (Entrez Gene)
TALDO1GeneProduct6888 (Entrez Gene)
TCA CyclePathway
TIGARGeneProductENSG00000078237 (Ensembl)
TKTGeneProduct7086 (Entrez Gene)
citrateMetaboliteHMDB00094 (HMDB)
fumarateMetaboliteHMDB00134 (HMDB)
glucoseMetaboliteCHEBI:17234 (ChEBI)
glutamateMetaboliteCHEBI:14321 (ChEBI)
glutamineMetaboliteCHEBI:28300 (ChEBI)
glycineMetaboliteCHEBI:15428 (ChEBI)
lipidsMetaboliteCHEBI:18059 (ChEBI)
serineMetaboliteCHEBI:17822 (ChEBI)

Annotated Interactions

<cite>No annotated interactions</cite>