LncRNA involvement in canonical Wnt signaling and colorectal cancer (Homo sapiens)

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Scaffold APC2 Legend Nucleus Transcriptional Activation Cytoplasm Proliferation Migration, invasion Stem cell maintenance Activating mutation Wnt target genes PLAU CCND1 JUN CCND3 FOSL1 MYC CCND2 RUVBL1 CSNK1E CDK6 MAPK Signaling MIR34A P P P CTNNB1 Cell cycle progression KREM1 CCAL MAP3K7 RBM5-AS1 CHD8 CDK8 26S Proteasome Degradation lnc34A TFAP2A ATF3 ROR1 RYK ROR2 GSK3B APC AXIN1 CSNK2B CSNK2A1 CSNK2A3 CSNK2A2 FRAT1 FRAT2 P P LEF1 TCF7L1 P P TCF7L2 TCF7 CTNNB1 TCF3 ASBEL WNT3A WNT7A WNT11 WNT1 WNT5B WNT2 WNT2B WNT6 WNT5A WNT16 WNT4 WNT3 WNT10B WNT7B WNT10A WNT16 H2AFY2 H19 EZH2 H19 CSNK1A1 CSNK1A1L DVL3 DVL2 DVL1 FZD3 FZD8 LRP5 FZD10 FZD7 FZD4 FZD1 LRP6 FZD6 FZD5 FZD9 FZD2 HNRNPK MYU CTNNB1 DKK1 DKK2 DKK4 SOST SERPINF1 SFRP1 SFRP2 SFRP4 SFRP5 NOTUM CER1 WIF1 PORCN NKD1 NKD2 CXXC4 SENP2 P NLK CTNNBIP1 SOX17 CTBP1 CTBP2 MIR16-2 MIR16-1 NKD1 HNRNPU H19 Inactivating mutation lncRNA miRNA AXIN2 Name: LncRNA involvement in canonical Wnt signaling and colorectal cancer Organism: Homo sapiens


Recently, long non-coding RNAs (lncRNAs) have emerged as significant players in CRC pathogenesis through diversified mechanisms. This pathway represents a review of long non-coding RNA (LncRNA) involvement in canonical Wnt signaling as it relates to colorectal cancer.

Core pathway is adapted from http://www.genome.jp/kegg-bin/show_pathway?hsa04310.

Quality Tags

Ontology Terms



  1. Shen P, Pichler M, Chen M, Calin GA, Ling H; ''To Wnt or Lose: The Missing Non-Coding Linc in Colorectal Cancer.''; Int J Mol Sci, 2017 PubMed


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97136view 14:42, 30 April 2018Khanspersconnected missing interaction
96917view 08:43, 19 April 2018Khanspersfixed broken interaction
96905view 12:14, 18 April 2018KhanspersModified description
96904view 11:52, 18 April 2018Khanspersfixed broken interaction
96890view 22:35, 17 April 2018KhanspersModified description
96889view 22:34, 17 April 2018Khansperschanged scaffold location
96888view 22:33, 17 April 2018KhanspersOntology Term : 'disease pathway' added !
96887view 22:33, 17 April 2018KhanspersOntology Term : 'Wnt signaling, canonical pathway' added !
96886view 22:32, 17 April 2018KhanspersOntology Term : 'colorectal cancer pathway' added !
96885view 22:31, 17 April 2018KhanspersModified title
96884view 22:31, 17 April 2018KhanspersNew pathway

External references


View all...
NameTypeDatabase referenceComment
26S Proteasome DegradationPathwayWP183 (WikiPathways)
APC2GeneProductENSG00000115266 (Ensembl)
APCGeneProduct324 (Entrez Gene)
ATF3GeneProductENSG00000162772 (Ensembl)
AXIN1GeneProduct8312 (Entrez Gene)
AXIN2GeneProductENSG00000168646 (Ensembl)
CCND1GeneProduct595 (Entrez Gene)
CCND2GeneProduct894 (Entrez Gene)
CCND3GeneProduct896 (Entrez Gene)
CDK6GeneProductENSG00000105810 (Ensembl)
CDK8GeneProductENSG00000132964 (Ensembl)
CER1GeneProductENSG00000147869 (Ensembl)
CHD8GeneProductENSG00000100888 (Ensembl)
CSNK1A1GeneProductENSG00000113712 (Ensembl)
CSNK1A1LGeneProductENSG00000180138 (Ensembl)
CSNK1EGeneProduct1454 (Entrez Gene)
CSNK2A1GeneProductENSG00000101266 (Ensembl)
CSNK2A2GeneProductENSG00000070770 (Ensembl)
CSNK2A3GeneProductENSG00000254598 (Ensembl)
CSNK2BGeneProductENSG00000204435 (Ensembl)
CTBP1GeneProductENSG00000159692 (Ensembl)
CTBP2GeneProductENSG00000175029 (Ensembl)
CTNNB1GeneProduct1499 (Entrez Gene)
CTNNBIP1GeneProductENSG00000178585 (Ensembl)
CXXC4GeneProductENSG00000168772 (Ensembl)
Cell cycle progressionPathwayWP179 (WikiPathways)
DKK1GeneProductENSG00000107984 (Ensembl)
DKK2GeneProductENSG00000155011 (Ensembl)
DKK4GeneProductENSG00000104371 (Ensembl)
DVL1GeneProduct1855 (Entrez Gene)
DVL2GeneProduct1856 (Entrez Gene)
DVL3GeneProduct1857 (Entrez Gene)
EZH2GeneProductENSG00000106462 (Ensembl)
FOSL1GeneProduct8061 (Entrez Gene)
FRAT1GeneProduct10023 (Entrez Gene)
FRAT2GeneProductENSG00000181274 (Ensembl)
FZD10GeneProduct11211 (Entrez Gene)
FZD1GeneProduct8321 (Entrez Gene)
FZD2GeneProduct2535 (Entrez Gene)
FZD3GeneProduct7976 (Entrez Gene)
FZD4GeneProduct6424 (Entrez Gene)
FZD5GeneProduct7855 (Entrez Gene)
FZD6GeneProduct8323 (Entrez Gene)
FZD7GeneProduct8324 (Entrez Gene)
FZD8GeneProduct8325 (Entrez Gene)
FZD9GeneProduct8326 (Entrez Gene)
GSK3BGeneProduct2932 (Entrez Gene)MOUSE:KG38 MOUSE
H19GeneProductENSG00000130600 (Ensembl)
H2AFY2GeneProductENSG00000099284 (Ensembl)
HNRNPKGeneProductENSG00000165119 (Ensembl)
HNRNPUGeneProductENSG00000153187 (Ensembl)
JUNGeneProduct3725 (Entrez Gene)
KREM1GeneProduct83999 (Entrez Gene)
LEF1GeneProductENSG00000138795 (Ensembl)
LRP5GeneProduct4041 (Entrez Gene)
LRP6GeneProduct4040 (Entrez Gene)
MAP3K7GeneProductENSG00000135341 (Ensembl)
MAPK SignalingPathwayWP382 (WikiPathways)
MIR16-1GeneProductENSG00000208006 (Ensembl)
MIR16-2GeneProductENSG00000198987 (Ensembl)
MIR34AGeneProductENSG00000228526 (Ensembl)
MYCGeneProduct4609 (Entrez Gene)
NKD1GeneProductENSG00000140807 (Ensembl)
NKD2GeneProductENSG00000145506 (Ensembl)
NLKGeneProductENSG00000087095 (Ensembl)
NOTUMGeneProductENSG00000185269 (Ensembl)
PLAUGeneProduct5328 (Entrez Gene)
PORCNGeneProductENSG00000102312 (Ensembl)
ROR1GeneProduct4919 (Entrez Gene)
ROR2GeneProduct4920 (Entrez Gene)
RUVBL1GeneProductENSG00000175792 (Ensembl)
RYKGeneProduct6259 (Entrez Gene)
SENP2GeneProductENSG00000163904 (Ensembl)
SERPINF1GeneProductENSG00000132386 (Ensembl)
SFRP1GeneProductENSG00000104332 (Ensembl)
SFRP2GeneProductENSG00000145423 (Ensembl)
SFRP4GeneProductENSG00000106483 (Ensembl)
SFRP5GeneProductENSG00000120057 (Ensembl)
SOSTGeneProductENSG00000167941 (Ensembl)
SOX17GeneProductENSG00000164736 (Ensembl)
TCF3GeneProductENSG00000071564 (Ensembl)
TCF7GeneProductENSG00000081059 (Ensembl)
TCF7L1GeneProductENSG00000152284 (Ensembl)
TCF7L2GeneProductENSG00000148737 (Ensembl)
TFAP2AGeneProductENSG00000137203 (Ensembl)
WIF1GeneProductENSG00000156076 (Ensembl)
WNT10AGeneProduct80326 (Entrez Gene)
WNT10BGeneProduct7480 (Entrez Gene)
WNT11GeneProduct7481 (Entrez Gene)
WNT16GeneProduct51384 (Entrez Gene)
WNT1GeneProduct7471 (Entrez Gene)
WNT2GeneProduct7472 (Entrez Gene)
WNT2BGeneProduct7482 (Entrez Gene)
WNT3GeneProduct7473 (Entrez Gene)
WNT3AGeneProduct89780 (Entrez Gene)
WNT4GeneProduct54361 (Entrez Gene)
WNT5AGeneProduct7474 (Entrez Gene)
WNT5BGeneProduct81029 (Entrez Gene)
WNT6GeneProduct7475 (Entrez Gene)
WNT7AGeneProduct7476 (Entrez Gene)
WNT7BGeneProduct7477 (Entrez Gene)

Annotated Interactions

<cite>No annotated interactions</cite>