Epithelial to mesenchymal transition in colorectal cancer (Homo sapiens)

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Nucelus Colorectal epithelial cell Other effectors TGFb and Ras/MAPK FMNL2 TUSC3 EIF5A2 STRAP NUBPL Claudins CLDN1 CLDN2 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CLDN9 CLDN10 CLDN11 CLDN12 CLDN14 CLDN15 CLDN16 CLDN17 CLDN18 CLDN19 CLDN20 CLDN22 CLDN23 CLDN24 Collagens COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 Epithelial-Mesenchymal Transition Hypoxia Ubiquitin-mediated degradation Degradation PROX1 P GSK3B GDF15 TMPRSS4 RAF1 Tyrosine kinase receptors FOXQ1 CTNNB1 RBPJ pre-miR-9-2 TP53 MEF2D NRP2 TRAF6 TGFBR1 TGFBR2 MAP2K1 MAP2K2 SMAD4 SMAD2 SMAD3 Collagen CDH2 FN1 VTN MMP15 MMP2 MMP9 ID1 ID2 FZD10 FZD2 FZD5 FZD3 FZD1 FZD4 FZD6 FZD7 FZD8 FZD9 LRP5 LRP6 JUP CDH1 Claudins OCLN DSP TGFB1 TGFB2 TGFB3 HRAS KRAS JAG1 JAG2 DLL1 DLL3 DLL4 DLK1 CDKL2 MMPs CDH2 VTN WNT16 WNT1 WNT4 WNT2 WNT3 WNT5A WNT6 WNT7A WNT7B WNT8A WNT8B WNT10B WNT11 WNT2B WNT9A WNT9B WNT10A WNT5B WNT3A WNT3A P TWIST1 P TWIST2 NOTCH1 NOTCH2 NOTCH3 NOTCH4 AKT1 AKT2 AKT3 MAPK3 MAPK1 Cytokeratins CDH1 Claudins DSP PKP1 PKP2 CRB3 MPP5 OCLN PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 NR2C2 MAP2K3 MAP2K6 MAP2K4 MAPK14 MAPK11 MAPK13 MAPK12 MAPK8 SHC1 GRB2 SOS1 SOS2 SNAI1 SNAI2 HIF1A ZEB2 FOXC2 FOXM1 P SNAI1 P P SNAI1 P SNAI1 CTDSP1 P P SNAI1 PKD1 PAK1 LATS2 P TWIST1 P TWIST2 TWIST1 TWIST2 Sumo ZEB2 Sumo ZEB2 SUZ12 RBBP4 EED EZH2 ZEB1 P SNAI1 CDH2 FN1 VTN SPARC ITGA5 CDH1 PKP1 PKP2 CRB3 TJP1 Name: Epithelial to mesenchymal transition in colorectal cancer Organism: Homo sapiens


Description

Epithelial to mesenchymal transition (EMT) is a process during which cells lose their epithelial characteristics, and gain mesenchymal properties, such as increased motility. In colorectal cancer (CRC), EMT is associated with an invasive or metastatic phenotype. During EMT, tumor cells undergo tight junction dissolution, disruption of apical–basal polarity, and reorganization of the cytoskeletal architecture, which enable cells to develop an invasive phenotype. In cancer cells, EMT is abnormally regulated by extracellular stimuli derived from the tumor microenvironment, including growth factors and inflammatory cytokines, along with intra-tumoral physical stresses such as hypoxia. Therefore, EMT programming allows tumor cells to adapt to the constant changes of the human tumor microenvironment, and thus to successfully metastasize. This pathway summarizes the major signaling pathways and inducers that promote EMT in CRC. A set of core transcription factors regulate EMT: SNAIL family of zinc-finger transcription factors SNAIL/SLUG; the zinc finger E-box binding homeobox (ZEB) family of transcription factors ZEB1/ZEB2, and the TWIST family of basic helix-loop-helix (bHLH) transcription factors TWIST1/TWIST2. (Adapted from Vu et al.)

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Ontology Terms

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Bibliography

  1. Kranenburg O; ''Prometastatic NOTCH Signaling in Colon Cancer.''; Cancer Discov, 2015 PubMed
  2. Lu MH, Huang CC, Pan MR, Chen HH, Hung WC; ''Prospero homeobox 1 promotes epithelial-mesenchymal transition in colon cancer cells by inhibiting E-cadherin via miR-9.''; Clin Cancer Res, 2012 PubMed
  3. Zhang H, Meng F, Liu G, Zhang B, Zhu J, Wu F, Ethier SP, Miller F, Wu G; ''Forkhead transcription factor foxq1 promotes epithelial-mesenchymal transition and breast cancer metastasis.''; Cancer Res, 2011 PubMed
  4. Yang C, Chen H, Tan G, Gao W, Cheng L, Jiang X, Yu L, Tan Y; ''FOXM1 promotes the epithelial to mesenchymal transition by stimulating the transcription of Slug in human breast cancer.''; Cancer Lett, 2013 PubMed
  5. Vu T, Datta PK; ''Regulation of EMT in Colorectal Cancer: A Culprit in Metastasis.''; Cancers (Basel), 2017 PubMed
  6. Lamouille S, Xu J, Derynck R; ''Molecular mechanisms of epithelial-mesenchymal transition.''; Nat Rev Mol Cell Biol, 2014 PubMed
  7. Abba M, Patil N, Rasheed K, Nelson LD, Mudduluru G, Leupold JH, Allgayer H; ''Unraveling the role of FOXQ1 in colorectal cancer metastasis.''; Mol Cancer Res, 2013 PubMed
  8. Li Q, Wu J, Wei P, Xu Y, Zhuo C, Wang Y, Li D, Cai S; ''Overexpression of forkhead Box C2 promotes tumor metastasis and indicates poor prognosis in colon cancer via regulating epithelial-mesenchymal transition.''; Am J Cancer Res, 2015 PubMed
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History

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RevisionActionTimeUserComment
97604view 05:00, 29 May 2018AMTanOntology Term : 'colon epithelial cell' added !
97583view 15:40, 26 May 2018AlexanderPicoModified title
97138view 15:02, 30 April 2018Khanspersadded cell label
97137view 14:54, 30 April 2018KhanspersModified title
97006view 16:30, 25 April 2018KhanspersModified title
96593view 16:50, 22 March 2018KhanspersModified description
96592view 16:17, 22 March 2018KhanspersOntology Term : 'disease of cellular proliferation' added !
96591view 13:56, 22 March 2018KhanspersModified description
96590view 13:45, 22 March 2018Khansperswork in progress
96586view 09:45, 22 March 2018KhanspersOntology Term : 'colorectal cancer' added !
96585view 21:27, 21 March 2018KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
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AKT2GeneProductENSG00000105221 (Ensembl)
AKT3GeneProductENSG00000117020 (Ensembl)
CDH1GeneProductENSG00000039068 (Ensembl)
CDH2GeneProductENSG00000170558 (Ensembl)
CDKL2GeneProductENSG00000138769 (Ensembl)
CLDN10GeneProductENSG00000134873 (Ensembl)
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CLDN12GeneProductENSG00000157224 (Ensembl)
CLDN14GeneProductENSG00000159261 (Ensembl)
CLDN15GeneProductENSG00000106404 (Ensembl)
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CLDN17GeneProductENSG00000156282 (Ensembl)
CLDN18GeneProductENSG00000066405 (Ensembl)
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CLDN7GeneProductENSG00000181885 (Ensembl)
CLDN8GeneProductENSG00000156284 (Ensembl)
CLDN9GeneProductENSG00000213937 (Ensembl)
COL4A1GeneProductENSG00000187498 (Ensembl)
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ZEB1GeneProductENSG00000148516 (Ensembl)
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pre-miR-9-2GeneProductENSG00000284447 (Ensembl)

Annotated Interactions

<cite>No annotated interactions</cite>