Ras Signaling (Homo sapiens)

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Scaffold Cell-cell junctions Growth Factors Endocytosis Inactive Apoptosis Cell-cycle arrest Ca2+ PIP3 GRIN1 GRIN2A GRIN2B RRAS RRAS2 MRAS HRAS KRAS NRAS GTP PLA2G4B PLA2G16 PLA2G4E PLA2G4F PLA2G2D PLA2G4D PLA2G2E PLA2G2C PLA2G3 PLA1A PLA2G1B PLA2G2A PLA2G4A PLA2G5 PLA2G2F PLA2G12A PLA2G6 PLA2G10 PLA2G12B PLA2G4C JMJD7-PLA2G4B GDP RRAS RRAS2 MRAS HRAS KRAS NRAS Ca2+ HTR7 CSF1R EGFR EPHA2 FGFR1 FGFR3 FGFR2 FGFR4 FLT1 FLT3 FLT4 IGF1R INSR KDR KIT MET NGFR NTRK1 NTRK2 PDGFRA PDGFRB TEK CALM1 CALM2 CALM3 CALML3 CALML4 CALML5 CALML6 P RASGRF1 P RASGRF2 cAMP PRKACA PRKACB PRKACG GNB5 GNB1 GNB2 GNB3 GNG3 GNG4 GNG5 GNG7 GNG10 GNG11 GNGT1 GNGT2 GNG13 GNG2 GNG12 GNB4 GNG8 PLCG1 PLCG2 DAG RASGRP1 RASGRP2 RASGRP3 RASGRP4 ZAP70 LAT IP3 Ca2+ GRB2 SHC1 SHC2 SHC3 SHC4 GAB1 GAB2 PTPN11 SOS1 SOS2 NF1 RASA4B RASA4 RASA3 RASA1 RASA2 RASAL3 RASAL1 SYNGAP1 RASAL2 RASSF1 RASSF5 STK4 STK4 TIAM1 RAC1 RAC2 RAC3 PAK4 BUB1B-PAK6 PAK1 PAK2 PAK3 PAK6 PAK5 RHOA Cytoskeleton organization Cell motility AKT1 AKT2 AKT3 P CHUK P IKBKB IKBKG NFKB1 RELA P BAD BCL2L1 FOXO4 FASLG Cell survival, growth, migration Cell cycle progression Transcription AFDN SHOC2 RAF1 KSR1 KSR2 P P MAP2K1 P P MAP2K2 P P MAPK1 P P MAPK3 BRAP ETS1 ETS2 ELK1 Gene expression RAPGEF5 RAP1A RAP1B RALGDS RGL1 RGL2 RALA RALB MAPK8 MAPK9 MAPK10 EXOC2 TTBK1 REL PLD1 PLD2 RALBP1 RAC1 RAC2 RAC3 CDC42 Gene expression PLCE1 DAG PRKCA PRKCB PRKCG RIN1 RALBP1 ARF6 RAC1 Cell spreading and migration RAB5A RAB5B RAB5C ABL1 ABL2 Endocytosis Cytoskeletal remodeling IP3 Ca2+ Active PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 Name: Ras Signaling Organism: Homo sapiens


Description

The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS). Pathway adapted from KEGG

When Ras is 'switched on' by incoming signals, it subsequently switches on other proteins, which ultimately turn on genes involved in cell growth, differentiation and survival. Mutations in ras genes can lead to the production of permanently activated Ras proteins. As a result, this can cause unintended and overactive signaling inside the cell, even in the absence of incoming signals. Because these signals result in cell growth and division, overactive Ras signaling can ultimately lead to cancer. The 3 Ras genes in humans (HRas, KRas, and NRas) are the most common oncogenes in human cancer; mutations that permanently activate Ras are found in 20% to 25% of all human tumors and up to 90% in certain types of cancer. Wikipedia

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Bibliography

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History

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RevisionActionTimeUserComment
96928view 10:53, 20 April 2018Khanspersremoved duplicated node
96927view 10:21, 20 April 2018Khanspersrefined layout and added phosphosites
96441view 01:03, 15 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
96363view 15:23, 9 March 2018KhanspersModified description
96274view 10:30, 4 March 2018KhanspersOntology Term : 'growth factor signaling pathway' added !
96273view 10:29, 4 March 2018KhanspersOntology Term : 'Ras superfamily mediated signaling pathway' added !
96238view 23:54, 1 March 2018KhanspersModified description
96237view 23:52, 1 March 2018KhanspersModified description
96236view 23:51, 1 March 2018KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ABL1GeneProductENSG00000097007 (Ensembl)
ABL2GeneProductENSG00000143322 (Ensembl)
AFDNGeneProduct4301 (Entrez Gene)
AKT1GeneProductENSG00000142208 (Ensembl)
AKT2GeneProductENSG00000105221 (Ensembl)
AKT3GeneProductENSG00000117020 (Ensembl)
ARF6GeneProductENSG00000165527 (Ensembl)
BADGeneProductENSG00000002330 (Ensembl)
BCL2L1GeneProductENSG00000171552 (Ensembl)
BRAPGeneProductENSG00000089234 (Ensembl)
BUB1B-PAK6GeneProductENSG00000259288 (Ensembl)
CALM1GeneProductENSG00000198668 (Ensembl)
CALM2GeneProductENSG00000143933 (Ensembl)
CALM3GeneProductENSG00000160014 (Ensembl)
CALML3GeneProductENSG00000178363 (Ensembl)
CALML4GeneProductENSG00000129007 (Ensembl)
CALML5GeneProductENSG00000178372 (Ensembl)
CALML6GeneProductENSG00000169885 (Ensembl)
CDC42GeneProductENSG00000070831 (Ensembl)
CHUKGeneProductENSG00000213341 (Ensembl)
CSF1RGeneProductENSG00000182578 (Ensembl)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
DAGMetaboliteCHEBI:18035 (ChEBI)
EGFRGeneProductENSG00000146648 (Ensembl)
ELK1GeneProductENSG00000126767 (Ensembl)
EPHA2GeneProductENSG00000142627 (Ensembl)
ETS1GeneProductENSG00000134954 (Ensembl)
ETS2GeneProductENSG00000157557 (Ensembl)
EXOC2GeneProductENSG00000112685 (Ensembl)
FASLGGeneProductENSG00000117560 (Ensembl)
FGFR1GeneProductENSG00000077782 (Ensembl)
FGFR2GeneProductENSG00000066468 (Ensembl)
FGFR3GeneProductENSG00000068078 (Ensembl)
FGFR4GeneProductENSG00000160867 (Ensembl)
FLT1GeneProductENSG00000102755 (Ensembl)
FLT3GeneProductENSG00000122025 (Ensembl)
FLT4GeneProductENSG00000037280 (Ensembl)
FOXO4GeneProductENSG00000184481 (Ensembl)
GAB1GeneProductENSG00000109458 (Ensembl)
GAB2GeneProductENSG00000033327 (Ensembl)
GDPMetaboliteCHEBI:17552 (ChEBI)
GNB1GeneProductENSG00000078369 (Ensembl)
GNB2GeneProductENSG00000172354 (Ensembl)
GNB3GeneProductENSG00000111664 (Ensembl)
GNB4GeneProductENSG00000114450 (Ensembl)
GNB5GeneProductENSG00000069966 (Ensembl)
GNG10GeneProductENSG00000242616 (Ensembl)
GNG11GeneProductENSG00000127920 (Ensembl)
GNG12GeneProductENSG00000172380 (Ensembl)
GNG13GeneProductENSG00000127588 (Ensembl)
GNG2GeneProductENSG00000186469 (Ensembl)
GNG3GeneProductENSG00000162188 (Ensembl)
GNG4GeneProductENSG00000168243 (Ensembl)
GNG5GeneProductENSG00000174021 (Ensembl)
GNG7GeneProductENSG00000176533 (Ensembl)
GNG8GeneProductENSG00000167414 (Ensembl)
GNGT1GeneProductENSG00000127928 (Ensembl)
GNGT2GeneProductENSG00000167083 (Ensembl)
GRB2GeneProductENSG00000177885 (Ensembl)
GRIN1GeneProductENSG00000176884 (Ensembl)
GRIN2AGeneProductENSG00000183454 (Ensembl)
GRIN2BGeneProductENSG00000273079 (Ensembl)
GTPMetaboliteCHEBI:15996 (ChEBI)
HRASGeneProductENSG00000174775 (Ensembl)
HTR7GeneProductENSG00000148680 (Ensembl)
IGF1RGeneProductENSG00000140443 (Ensembl)
IKBKBGeneProductENSG00000104365 (Ensembl)
IKBKGGeneProductENSG00000269335 (Ensembl)
INSRGeneProductENSG00000171105 (Ensembl)
IP3MetaboliteCHEBI:16595 (ChEBI)
JMJD7-PLA2G4BGeneProductENSG00000168970 (Ensembl)
KDRGeneProductENSG00000128052 (Ensembl)
KITGeneProductENSG00000157404 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
KSR1GeneProductENSG00000141068 (Ensembl)
KSR2GeneProductENSG00000171435 (Ensembl)
LATGeneProduct27040 (Entrez Gene)
MAP2K1GeneProductENSG00000169032 (Ensembl)
MAP2K2GeneProductENSG00000126934 (Ensembl)
MAPK10GeneProductENSG00000109339 (Ensembl)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
MAPK8GeneProductENSG00000107643 (Ensembl)
MAPK9GeneProductENSG00000050748 (Ensembl)
METGeneProduct4233 (Entrez Gene)
MRASGeneProductENSG00000158186 (Ensembl)
NF1GeneProduct4763 (Entrez Gene)
NFKB1GeneProductENSG00000109320 (Ensembl)
NGFRGeneProductENSG00000064300 (Ensembl)
NRASGeneProductENSG00000213281 (Ensembl)
NTRK1GeneProductENSG00000198400 (Ensembl)
NTRK2GeneProductENSG00000148053 (Ensembl)
PAK1GeneProductENSG00000149269 (Ensembl)
PAK2GeneProductENSG00000180370 (Ensembl)
PAK3GeneProductENSG00000077264 (Ensembl)
PAK4GeneProductENSG00000130669 (Ensembl)
PAK5GeneProductENSG00000101349 (Ensembl)
PAK6GeneProductENSG00000137843 (Ensembl)
PDGFRAGeneProductENSG00000134853 (Ensembl)
PDGFRBGeneProductENSG00000113721 (Ensembl)
PIK3CAGeneProductENSG00000121879 (Ensembl)
PIK3CBGeneProductENSG00000051382 (Ensembl)
PIK3CDGeneProductENSG00000171608 (Ensembl)
PIK3R1GeneProductENSG00000145675 (Ensembl)
PIK3R2GeneProductENSG00000105647 (Ensembl)
PIK3R3GeneProductENSG00000117461 (Ensembl)
PIP3MetaboliteCHEBI:16618 (ChEBI)
PLA1AGeneProductENSG00000144837 (Ensembl)
PLA2G10GeneProductENSG00000069764 (Ensembl)
PLA2G12AGeneProductENSG00000123739 (Ensembl)
PLA2G12BGeneProductENSG00000138308 (Ensembl)
PLA2G16GeneProductENSG00000176485 (Ensembl)
PLA2G1BGeneProductENSG00000170890 (Ensembl)
PLA2G2AGeneProductENSG00000188257 (Ensembl)
PLA2G2CGeneProductENSG00000187980 (Ensembl)
PLA2G2DGeneProductENSG00000117215 (Ensembl)
PLA2G2EGeneProductENSG00000188784 (Ensembl)
PLA2G2FGeneProductENSG00000158786 (Ensembl)
PLA2G3GeneProductENSG00000100078 (Ensembl)
PLA2G4AGeneProductENSG00000116711 (Ensembl)
PLA2G4BGeneProductENSG00000243708 (Ensembl)
PLA2G4CGeneProductENSG00000105499 (Ensembl)
PLA2G4DGeneProductENSG00000159337 (Ensembl)
PLA2G4EGeneProductENSG00000188089 (Ensembl)
PLA2G4FGeneProductENSG00000168907 (Ensembl)
PLA2G5GeneProductENSG00000127472 (Ensembl)
PLA2G6GeneProductENSG00000184381 (Ensembl)
PLCE1GeneProductENSG00000138193 (Ensembl)
PLCG1GeneProductENSG00000124181 (Ensembl)
PLCG2GeneProductENSG00000197943 (Ensembl)
PLD1GeneProductENSG00000075651 (Ensembl)
PLD2GeneProductENSG00000129219 (Ensembl)
PRKACAGeneProductENSG00000072062 (Ensembl)
PRKACBGeneProductENSG00000142875 (Ensembl)
PRKACGGeneProductENSG00000165059 (Ensembl)
PRKCAGeneProductENSG00000154229 (Ensembl)
PRKCBGeneProductENSG00000166501 (Ensembl)
PRKCGGeneProductENSG00000126583 (Ensembl)
PTPN11GeneProductENSG00000179295 (Ensembl)
RAB5AGeneProductENSG00000144566 (Ensembl)
RAB5BGeneProductENSG00000111540 (Ensembl)
RAB5CGeneProductENSG00000108774 (Ensembl)
RAC1GeneProductENSG00000136238 (Ensembl)
RAC2GeneProductENSG00000128340 (Ensembl)
RAC3GeneProductENSG00000169750 (Ensembl)
RAF1GeneProductENSG00000132155 (Ensembl)
RALAGeneProductENSG00000006451 (Ensembl)
RALBGeneProductENSG00000144118 (Ensembl)
RALBP1GeneProductENSG00000017797 (Ensembl)
RALGDSGeneProductENSG00000160271 (Ensembl)
RAP1AGeneProductENSG00000116473 (Ensembl)
RAP1BGeneProductENSG00000127314 (Ensembl)
RAPGEF5GeneProductENSG00000136237 (Ensembl)
RASA1GeneProductENSG00000145715 (Ensembl)
RASA2GeneProductENSG00000155903 (Ensembl)
RASA3GeneProductENSG00000185989 (Ensembl)
RASA4BGeneProductENSG00000170667 (Ensembl)
RASA4GeneProductENSG00000105808 (Ensembl)
RASAL1GeneProductENSG00000111344 (Ensembl)
RASAL2GeneProductENSG00000075391 (Ensembl)
RASAL3GeneProductENSG00000105122 (Ensembl)
RASGRF1GeneProductENSG00000058335 (Ensembl)
RASGRF2GeneProductENSG00000113319 (Ensembl)
RASGRP1GeneProductENSG00000172575 (Ensembl)
RASGRP2GeneProductENSG00000068831 (Ensembl)
RASGRP3GeneProductENSG00000152689 (Ensembl)
RASGRP4GeneProductENSG00000171777 (Ensembl)
RASSF1GeneProductENSG00000068028 (Ensembl)
RASSF5GeneProductENSG00000266094 (Ensembl)
RELGeneProduct5966 (Entrez Gene)
RELAGeneProduct5970 (Entrez Gene)
RGL1GeneProductENSG00000143344 (Ensembl)
RGL2GeneProductENSG00000237441 (Ensembl)
RHOAGeneProductENSG00000067560 (Ensembl)
RIN1GeneProductENSG00000174791 (Ensembl)
RRAS2GeneProductENSG00000133818 (Ensembl)
RRASGeneProductENSG00000126458 (Ensembl)
SHC1GeneProductENSG00000160691 (Ensembl)
SHC2GeneProductENSG00000129946 (Ensembl)
SHC3GeneProductENSG00000148082 (Ensembl)
SHC4GeneProductENSG00000185634 (Ensembl)
SHOC2GeneProductENSG00000108061 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
SOS2GeneProductENSG00000100485 (Ensembl)
STK4GeneProductENSG00000101109 (Ensembl)
SYNGAP1GeneProductENSG00000197283 (Ensembl)
TEKGeneProductENSG00000120156 (Ensembl)
TIAM1GeneProductENSG00000156299 (Ensembl)
TTBK1GeneProductENSG00000146216 (Ensembl)
ZAP70GeneProductENSG00000115085 (Ensembl)
cAMPMetaboliteCHEBI:17489 (ChEBI)

Annotated Interactions

<cite>No annotated interactions</cite>