PDGFR-beta pathway (Homo sapiens)

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Nucleus P PIK3CA PDGFRB P PLCG1 P PRKCA P ERK1 P GRB1 P JAK1 P PRKCB STAT6 P JAK2 PKR P STAT3 P STAT1 P STAT5A GRB2 P HRAS P SOS1 P SHC1 P RASA1 P MEKK MEK1 P STAT5B JNK1 P JNKK1 P RAF1 ELK1 P SRF FOS P JUN Cytoplasm Extracellular Name: PDGFR-beta pathway Organism: Homo sapiens


Description

Simplified PDGFR-beta pathway, based on figure 7B from Zhang et al: https://www.ncbi.nlm.nih.gov/pubmed/27372738

Platelet-derived growth factor receptors (PDGFR) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family. PDGF subunits -A and -B are important factors regulating cell proliferation, cellular differentiation, cell growth, development and many diseases including cancer. There are two forms of the PDGFR, alpha and beta each encoded by a different gene. Depending on which growth factor is bound, PDGFR homo- or heterodimerizes. Source: Wikipedia

Quality Tags

Ontology Terms

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Bibliography

  1. Zhang H, Liu T, Zhang Z, Payne SH, Zhang B, McDermott JE, Zhou JY, Petyuk VA, Chen L, Ray D, Sun S, Yang F, Wang J, Shah P, Cha SW, Aiyetan P, Woo S, Tian Y, Gritsenko MA, Clauss TR, Choi C, Monroe ME, Thomas S, Nie S, Wu C, Moore RJ, Yu KH, Tabb DL, Fenyö D, Bafna V, Wang Y, Rodriguez H, Boja ES, Hiltke T, Rivers RC, Sokoll L, Zhu H, Shih IeM, Cope L, Pandey A, Snyder MP, Levine DA, Smith RD, Chan DW, Rodland KD; ''Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer.''; Cell, 2016 PubMed

History

RevisionActionTimeUserComment
92088view 11:24, 25 April 2017AlexanderPicoModified description
91861view 14:26, 31 March 2017KhanspersModified description
91860view 14:13, 31 March 2017KhanspersOntology Term : 'ovarian cancer pathway' added !
91859view 14:13, 31 March 2017KhanspersOntology Term : 'signaling pathway' added !
91852view 14:02, 31 March 2017KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ELK1GeneProductENSG00000126767 (Ensembl)
ERK1GeneProductENSG00000102882 (Ensembl)
FOSGeneProductENSG00000170345 (Ensembl)
GRB1GeneProductENSG00000145675 (Ensembl)
GRB2GeneProductENSG00000177885 (Ensembl)
HRASGeneProductENSG00000174775 (Ensembl)
JAK1GeneProductENSG00000162434 (Ensembl)
JAK2GeneProductENSG00000096968 (Ensembl)
JNK1GeneProductENSG00000107643 (Ensembl)
JNKK1GeneProductENSG00000065559 (Ensembl)
JUNGeneProductENSG00000177606 (Ensembl)
MEK1GeneProductENSG00000169032 (Ensembl)
MEKKGeneProductENSG00000095015 (Ensembl)
PDGFRBGeneProductENSG00000113721 (Ensembl)
PIK3CAGeneProductENSG00000121879 (Ensembl)
PKRGeneProductENSG00000055332 (Ensembl)
PLCG1GeneProductENSG00000124181 (Ensembl)
PRKCAGeneProductENSG00000154229 (Ensembl)
PRKCBGeneProductENSG00000166501 (Ensembl)
RAF1GeneProductENSG00000132155 (Ensembl)
RASA1GeneProductENSG00000145715 (Ensembl)
SHC1GeneProductENSG00000160691 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
SRFGeneProductENSG00000112658 (Ensembl)
STAT1GeneProductENSG00000115415 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
STAT5AGeneProductENSG00000126561 (Ensembl)
STAT5BGeneProductENSG00000173757 (Ensembl)
STAT6GeneProductENSG00000166888 (Ensembl)

Annotated Interactions

<cite>No annotated interactions</cite>