Hexoses metabolism in proximal tubules (Rattus norvegicus)

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Neutral lipid Synthesis Lipid Droplets Cytosol Mitochondrion Tpi1 1,3BP-Glycerate Pyruvate Glucose Fructose 6P Pyruvate Gpi P-enolpyruvate Pentose Phosphate Pathway Lactate 3P-Glycerate Glycogen Metabolism Fatty Acid Synthesis Acetyl-CoA 2P-Glycerate Dihydroxyacetone-P Gapdh Fructose-1,6BP Glucose-6P Glucose Hk1 Glyceraldehyde 3P Pklr Pkm Pdp2 Pdp1 Mpc1 mpc2 Aldoa Aldoc Aldob Slc2a2 Slc5a1 Slc2a5 Slc5a2 Pgam1 Pgam2 Pgk1 Pgk2 Dlat Dld Pdha2 Pdhb Pdhx Pdha1 Pdk1 Pdk3 Pdk2 Pdk4 Fbp1 Oxalacetate Pc Malate Malate Oxalacetate Aspartate Citrate Aspartate Citrate Acetyl-CoA Acly Pfkl Pfkp Pfkm Tkfc Sord Fructose Khk Sorbitol Fructose-1-P Glyderaldehyde Aldob Akr1b1 Polyol Pathway specific steps Fructose G6pc Hk1 Low affinity for fructose Rate limiting step Eno1 Eno3 Eno2 Extracellular Pck1 Got1 Got2 Mdh2 Mdh1 Cs Diacylglycerol Synthesis Ldhb Ldha Slc5a10 Slc2a2 Slc5a9 Slc2a5 Name: Hexoses metabolism in proximal tubules License: CC BY 2.0 Organism: Rattus norvegicus


The role of glucose, fructose and the citric acid cycle in lipid synthesis in proximal tubules.

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Ontology Terms



  1. Fukuzawa T, Fukazawa M, Ueda O, Shimada H, Kito A, Kakefuda M, Kawase Y, Wada NA, Goto C, Fukushima N, Jishage K, Honda K, King GL, Kawabe Y; ''SGLT5 reabsorbs fructose in the kidney but its deficiency paradoxically exacerbates hepatic steatosis induced by fructose.''; PLoS One, 2013 PubMed
  2. Tazawa S, Yamato T, Fujikura H, Hiratochi M, Itoh F, Tomae M, Takemura Y, Maruyama H, Sugiyama T, Wakamatsu A, Isogai T, Isaji M; ''SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose.''; Life Sci., 2005 PubMed
  3. Grempler R, Augustin R, Froehner S, Hildebrandt T, Simon E, Mark M, Eickelmann P; ''Functional characterisation of human SGLT-5 as a novel kidney-specific sodium-dependent sugar transporter''; FEBS Lett., 2012 PubMed


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91332view 11:22, 2 February 2017Khanspersconnected interaction
90672view 14:56, 5 December 2016MaintBotFixed confusion between HMDB datasource but CAS identifier
90642view 11:37, 4 December 2016AlexanderPicoManually fixed lit refs
90641view 11:27, 4 December 2016AlexanderPicoUpdated lit refs, cell compartments, groups and metabolite colors
90640view 11:13, 4 December 2016AlexanderPicoModified description
90525view 12:19, 21 November 2016AgustinGVSpecify description
90524view 12:16, 21 November 2016AgustinGVUpdate tissue specific glucose transporters
90494view 14:24, 17 November 2016AgustinGVSpecify description
90493view 14:18, 17 November 2016AgustinGVOntology Term : 'PW:0000041' removed !
90492view 14:18, 17 November 2016AgustinGVOntology Term : 'epithelial cell of proximal tubule' added !
90491view 14:17, 17 November 2016AgustinGVOntology Term : 'inherited metabolic disorder' added !
90490view 14:17, 17 November 2016AgustinGVOntology Term : 'acquired metabolic disease' added !
90489view 14:16, 17 November 2016AgustinGVOntology Term : 'disease of metabolism' added !
90488view 14:16, 17 November 2016AgustinGVOntology Term : 'fructose and mannose metabolic pathway' added !
90487view 14:16, 17 November 2016AgustinGVOntology Term : 'glycolysis/gluconeogenesis pathway' added !
90486view 14:16, 17 November 2016AgustinGVOntology Term : 'classic metabolic pathway' added !
90485view 14:15, 17 November 2016AgustinGVOntology Term : 'carbohydrate metabolic pathway' added !
90484view 14:15, 17 November 2016AgustinGVSpecify description
90483view 13:29, 17 November 2016AgustinGVSpecify description
90482view 13:27, 17 November 2016AgustinGVSpecify description
90481view 13:27, 17 November 2016AgustinGVAdd Ldh a/b
90480view 13:09, 17 November 2016AgustinGVFix wrong interaction
90479view 12:44, 17 November 2016AgustinGVSpecify description
90478view 12:29, 17 November 2016AgustinGVSpecify description
90477view 12:28, 17 November 2016AgustinGVSpecify description
90476view 12:23, 17 November 2016AgustinGVSpecify description
90475view 12:20, 17 November 2016AgustinGVPeriodical save, work in progress
90474view 12:14, 17 November 2016AgustinGVSpecify description
90473view 11:58, 17 November 2016AgustinGVSpecify description
90472view 11:57, 17 November 2016AgustinGVPeriodical save, work in progress
90471view 11:51, 17 November 2016AgustinGVSpecify description
90470view 11:50, 17 November 2016AgustinGVSpecify description
90469view 11:44, 17 November 2016AgustinGVModified title
90468view 11:43, 17 November 2016AgustinGVNew pathway

External references


View all...
NameTypeDatabase referenceComment
1,3BP-GlycerateMetaboliteHMDB01270 (HMDB)
2P-GlycerateMetaboliteHMDB00362 (HMDB)
3P-GlycerateMetaboliteHMDB00807 (HMDB)
Acetyl-CoAMetabolite72-89-9 (CAS)
AclyGeneProduct24159 (Entrez Gene)
Akr1b1GeneProduct24192 (Entrez Gene)
AldoaGeneProduct24189 (Entrez Gene)
AldobGeneProduct24190 (Entrez Gene)
AldocGeneProduct24191 (Entrez Gene)
AspartateMetabolite6915-15-7 (CAS)
CitrateMetabolite6915-15-7 (CAS)
CsGeneProduct170587 (Entrez Gene)
Diacylglycerol SynthesisPathway
Dihydroxyacetone-PMetaboliteHMDB01473 (HMDB)
DlatGeneProduct81654 (Entrez Gene)
DldGeneProduct298942 (Entrez Gene)
Eno1GeneProduct24333 (Entrez Gene)
Eno2GeneProduct24334 (Entrez Gene)
Eno3GeneProduct25438 (Entrez Gene)
Fatty Acid SynthesisPathway
Fbp1Protein24362 (Entrez Gene)
Fructose 6PMetaboliteHMDB00124 (HMDB)
Fructose-1,6BPMetaboliteHMDB01058 (HMDB)
Fructose-1-PMetaboliteHMDB01076 (HMDB)
FructoseMetaboliteHMDB00660 (HMDB)
G6pcGeneProduct25634 (Entrez Gene)
GapdhGeneProduct24383 (Entrez Gene)
Glucose-6PMetaboliteHMDB01401 (HMDB)
GlucoseMetaboliteHMDB00122 (HMDB)
Glyceraldehyde 3PMetaboliteHMDB01112 (HMDB)
Glycogen MetabolismPathway
GlyderaldehydeMetaboliteHMDB01051 (HMDB)
Got1GeneProduct24401 (Entrez Gene)
Got2GeneProduct25721 (Entrez Gene)
GpiGeneProduct292804 (Entrez Gene)
Hk1GeneProduct25058 (Entrez Gene)
KhkGeneProduct25659 (Entrez Gene)
LactateMetabolite79-33-4 (CAS)
LdhaGeneProduct24533 (Entrez Gene)Make sure to differentiate between M1 and M2 isoform
LdhbGeneProduct24534 (Entrez Gene)2 Isoforms: L Liver and R red cells
MalateMetabolite6915-15-7 (CAS)
Mdh1GeneProduct24551 (Entrez Gene)
Mdh2GeneProduct81829 (Entrez Gene)
Mpc1GeneProduct171087 (Entrez Gene)
Neutral lipid


Lipid Droplets
Pathwaywp (WikiPathways)
OxalacetateMetaboliteHMDB00223 (HMDB)
P-enolpyruvateMetaboliteHMDB00263 (HMDB)
PcGeneProduct25104 (Entrez Gene)
Pck1GeneProduct362282 (Entrez Gene)
Pdha1GeneProduct29554 (Entrez Gene)
Pdha2GeneProduct117098 (Entrez Gene)
PdhbGeneProduct289950 (Entrez Gene)
PdhxGeneProduct311254 (Entrez Gene)
Pdk1GeneProduct116551 (Entrez Gene)
Pdk2GeneProduct81530 (Entrez Gene)
Pdk3GeneProduct296849 (Entrez Gene)
Pdk4GeneProduct89813 (Entrez Gene)
Pdp1GeneProduct54705 (Entrez Gene)
Pdp2GeneProduct246311 (Entrez Gene)
Pentose Phosphate PathwayPathway
PfklGeneProduct25741 (Entrez Gene)
PfkmGeneProduct65152 (Entrez Gene)
PfkpGeneProduct60416 (Entrez Gene)
Pgam1GeneProduct24642 (Entrez Gene)
Pgam2GeneProduct24959 (Entrez Gene)
Pgk1GeneProduct24644 (Entrez Gene)
Pgk2GeneProduct316265 (Entrez Gene)
PklrGeneProduct24651 (Entrez Gene)Make sure to differentiate between M1 and M2 isoform
PkmGeneProduct25630 (Entrez Gene)2 Isoforms: L Liver and R red cells
PyruvateMetaboliteHMDB00243 (HMDB)
Slc2a2GeneProduct25351 (Entrez Gene)
Slc2a5GeneProduct65197 (Entrez Gene)
Slc5a10GeneProduct303205 (Entrez Gene)
Slc5a1GeneProduct25552 (Entrez Gene)
Slc5a2GeneProduct64522 (Entrez Gene)
Slc5a9GeneProduct366441 (Entrez Gene)
SorbitolMetaboliteHMDB00247 (HMDB)
SordGeneProduct24788 (Entrez Gene)
TkfcGeneProduct361730 (Entrez Gene)
Tpi1GeneProduct24849 (Entrez Gene)
mpc2GeneProduct100359982 (Entrez Gene)

Annotated Interactions

<cite>No annotated interactions</cite>