Lipid Droplet Metabolism (Rattus norvegicus)

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Fatty Acids Activation Lipid Droplet Structural Proteins Plin2 Aup1 Bscl2 Fitm2 Fatty Acids DAG Acyl-CoA Acsl1 Acsl3 Acsl4 Cholesterol Phosphatidic Acid Glycerol Pnpla2 Lipa Triglycerides Cholesterol Esters Dgat1 Dgat2 Soat1 Soat2 Lipa LysoPhosphatidic Acid Glycerol-3-P DHA-P Gk Gpat2 Agpat3 Agpat1 Agpat4 Agpat2 Agpat5 Lpin1 Lpin2 Lpin3 Gpd1 Gpd2 Name: Lipid Droplet Metabolism Organism: Rattus norvegicus


Description

Lipid droplets are cytosolic organelles present in nearly all cell types. Initially they were considered only as inert lipid-storage sites, but now they are recognized to be involved in other functions and even associated with liver and kidney disease. Still, the mechanisms for lipid accumulation into the lipid droplet are not totally understood. Even though the lipid and protein composition of the lipid droplets is highly dynamic, triglycerides and cholesterol esters are the main components of them. This pathway features the basic enzymatic steps necessary to esterify glycerol and cholesterol.

Quality Tags

Ontology Terms

<OntologyTags></OntologyTags>

Bibliography

  1. Pol A, Gross SP, Parton RG; ''Review: biogenesis of the multifunctional lipid droplet: lipids, proteins, and sites.''; J Cell Biol, 2014 PubMed

History

View all...
RevisionActionTimeUserComment
90646view 11:54, 4 December 2016AlexanderPicoUpdated catalysis reactions
90414view 01:16, 12 November 2016EgonwAdded ChEBI identifiers for a few compound classes.
90413view 01:10, 12 November 2016EgonwIdentifiers are case sensitive.
90315view 14:46, 3 November 2016AgustinGV
90307view 12:58, 3 November 2016AgustinGVFix IDs
90303view 11:15, 3 November 2016AgustinGVOntology Term : 'lipid metabolic pathway' added !
90302view 11:14, 3 November 2016AgustinGVOntology Term : 'lipid metabolism disorder' added !
90301view 11:14, 3 November 2016AgustinGVOntology Term : 'neutral lipid storage disease' added !
90300view 11:12, 3 November 2016AgustinGV
90299view 11:09, 3 November 2016AgustinGVModified description
90298view 10:54, 3 November 2016AgustinGV
90297view 10:52, 3 November 2016AgustinGV
90296view 10:44, 3 November 2016AgustinGVNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Acsl1GeneProduct25288 (Entrez Gene)
Acsl3GeneProduct114024 (Entrez Gene)
Acsl4GeneProduct113976 (Entrez Gene)
Acyl-CoAMetaboliteCHEBI:58342 (ChEBI)
Agpat1GeneProduct406165 (Entrez Gene)
Agpat2GeneProduct311821 (Entrez Gene)
Agpat3GeneProduct294324 (Entrez Gene)
Agpat4GeneProduct170919 (Entrez Gene)
Agpat5GeneProduct306582 (Entrez Gene)
Aup1GeneProduct680423 (Entrez Gene)
Bscl2GeneProduct361722 (Entrez Gene)
Cholesterol EstersMetaboliteCHEBI:17002 (ChEBI)
CholesterolMetaboliteHMDB00067 (HMDB)
DAGMetabolite
DHA-PMetaboliteHMDB01473 (HMDB)
Dgat1GeneProduct84497 (Entrez Gene)
Dgat2GeneProduct252900 (Entrez Gene)
Fatty AcidsMetaboliteCHEBI:35366 (ChEBI)
Fitm2GeneProduct311617 (Entrez Gene)
GkGeneProduct79223 (Entrez Gene)
Glycerol-3-PMetaboliteHMDB00126 (HMDB)
GlycerolMetaboliteHMDB00131 (HMDB)
Gpat2GeneProduct296130 (Entrez Gene)
Gpd1GeneProduct60666 (Entrez Gene)
Gpd2GeneProduct25062 (Entrez Gene)
LipaGeneProduct25055 (Entrez Gene)
Lpin1GeneProduct313977 (Entrez Gene)
Lpin2GeneProduct316737 (Entrez Gene)
Lpin3GeneProduct362261 (Entrez Gene)
LysoPhosphatidic AcidMetabolite
Phosphatidic AcidMetaboliteCHEBI:16337 (ChEBI)
Plin2GeneProduct298199 (Entrez Gene)
Pnpla2GeneProduct361676 (Entrez Gene)
Soat1GeneProduct81782 (Entrez Gene)
Soat2GeneProduct266770 (Entrez Gene)
TriglyceridesMetaboliteCHEBI:17855 (ChEBI)

Annotated Interactions

<cite>No annotated interactions</cite>