Fructose Metabolism in Proximal Tubules (Rattus norvegicus)

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Slc5a10 Slc2a5 Slc5a9 Slc2a2 Fructose transporters Polyol Pathway specific steps Low affinity for fructose Payoff phase of glycolysis Neutral lipid Synthesis Gpi Tkfc Sord Fbp1 G6pc Fructose Akr1b1 Glucose Khk Pfkl Pfkp Pfkm Aldoa Aldob Glucose-6-P Fructose-6-P Sorbitol Fructose-1-P Fructose-1,6-biP Glyderaldehyde-3-P Dihydroacetone-P Glyderaldehyde Aldob Tpi1 Hk1 Hk1 Rate limiting step Name: Fructose Metabolism in Proximal Tubules Organism: Rattus norvegicus


Description

Most of the fructose absorbed in the gut is cleared in its first hepatic passage; however, under certain conditions, such as ingestion of large amounts of free fructose, the sugar can reach high levels in plasma and filtrate through the glomeruli. Filtered fructose is reabsorbed by proximal tubule cells. Ingestion of large quantities of free fructose, usually from high fructose corn syrup, has been associated with obesity, metabolic syndrome and elevated blood pressure. Salt-sensitivity of blood pressure in rodents receiving 10 or 20% fructose solutions is well documented. Sensitivity to salt, should include a renal defect, otherwise pressure natriuretis would restore Na balance. Since the bulk of fructose and other sugars are absorbed in proximal tubules, it is believed that fructose affect this nephron segment first. This pathway features the metabolism of fructose in proximal tubule cells. It was created using biochemical data showing metabolites accumulation and enzymatic activities in proximal tubules challenged with fructose. Also deep sequencing data from microdissected renal proximal tubules was used to confirm the presence of the transcript of the enzymes. Gene transcripts are annotated using ENTREZ Gene ID.

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Ontology Terms

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Bibliography

  1. Burch HB, Choi S, Dence CN, Alvey TR, Cole BR, Lowry OH.; ''''; , PubMed
  2. ''''; , PubMed
  3. ''''; , PubMed
  4. Lee JW, Chou CL, Knepper MA; ''Deep Sequencing in Microdissected Renal Tubules Identifies Nephron Segment-Specific Transcriptomes.''; J Am Soc Nephrol, 2015 PubMed
  5. ''''; , PubMed
  6. ''''; , PubMed
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History

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RevisionActionTimeUserComment
91517view 11:54, 8 March 2017Khanspersfixed xref for pathway node
90399view 07:55, 11 November 2016AgustinGVModified description
90398view 07:41, 11 November 2016AgustinGVReferences added
90397view 07:38, 11 November 2016AgustinGVSpecify description
90396view 07:37, 11 November 2016AgustinGVModified title
90395view 07:35, 11 November 2016AgustinGVAdd Fructose Transporters
90394view 07:05, 11 November 2016AgustinGVMore info on text
90393view 07:02, 11 November 2016AgustinGVAdd descriptions and info on text
90392view 06:56, 11 November 2016AgustinGVSpecify description
90391view 06:56, 11 November 2016AgustinGVSpecify description
90386view 14:57, 10 November 2016AgustinGVSpecify description
90385view 14:14, 10 November 2016AgustinGV
90383view 11:30, 10 November 2016AgustinGV
90382view 11:26, 10 November 2016AgustinGV
90381view 11:23, 10 November 2016AgustinGV
89604view 11:08, 19 September 2016AgustinGVModified description
89603view 11:05, 19 September 2016AgustinGVModified description
89598view 09:00, 19 September 2016AgustinGVOntology Term : 'hypertension' added !
89597view 08:59, 19 September 2016AgustinGVOntology Term : 'renal hypertension' added !
89596view 08:59, 19 September 2016AgustinGVOntology Term : 'epithelial cell of proximal tubule' added !
89595view 08:59, 19 September 2016AgustinGVModified description
89569view 00:53, 17 September 2016EgonwFixed casing in two HDMB identifiers.
89566view 06:53, 16 September 2016AgustinGVCorrect misalignment
89565view 06:46, 16 September 2016AgustinGVCorrect misalignment
89559view 06:35, 16 September 2016AgustinGVAdd ID
89558view 06:33, 16 September 2016AgustinGVModified description
89557view 06:32, 16 September 2016AgustinGVAdd ID
89556view 06:31, 16 September 2016AgustinGVAdd ID
89555view 06:30, 16 September 2016AgustinGVAdd Identifier
89554view 06:28, 16 September 2016AgustinGVSpecify description
89550view 06:23, 16 September 2016AgustinGVModified description
89549view 06:23, 16 September 2016AgustinGVModified description
89499view 09:24, 15 September 2016AgustinGVOntology Term : 'hereditary fructose intolerance syndrome' added !
89498view 09:23, 15 September 2016AgustinGVOntology Term : 'fructose-1,6-bisphosphatase deficiency' added !
89497view 09:22, 15 September 2016AgustinGVOntology Term : 'carbohydrate metabolic pathway' added !
89495view 09:11, 15 September 2016AgustinGVSpecify description
89494view 08:59, 15 September 2016AgustinGVNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Akr1b1GeneProduct24192 (Entrez Gene)
AldoaGeneProduct24189 (Entrez Gene)
AldobGeneProduct24190 (Entrez Gene)
Dihydroacetone-PMetaboliteHMDB01473 (HMDB)
Fbp1GeneProduct24362 (Entrez Gene)
Fructose-1,6-biPMetaboliteHMDB01058 (HMDB)
Fructose-1-PMetaboliteHMDB01076 (HMDB)
Fructose-6-PMetaboliteHMDB00124 (HMDB)
FructoseMetaboliteHMDB00660 (HMDB)
G6pcGeneProduct25634 (Entrez Gene)
Glucose-6-PMetaboliteHMDB01401 (HMDB)
GlucoseMetaboliteHMDB00122 (HMDB)
Glyderaldehyde-3-PMetaboliteHMDB01112 (HMDB)
GlyderaldehydeMetaboliteHMDB01051 (HMDB)
GpiGeneProduct292804 (Entrez Gene)
Hk1GeneProduct25058 (Entrez Gene)
KhkGeneProduct25659 (Entrez Gene)
Neutral lipid SynthesisPathwayWP3901 (WikiPathways)
PfklGeneProduct25741 (Entrez Gene)
PfkmGeneProduct65152 (Entrez Gene)
PfkpGeneProduct60416 (Entrez Gene)
Slc2a2GeneProduct25351 (Entrez Gene)
Slc2a5GeneProduct65197 (Entrez Gene)
Slc5a10GeneProduct303205 (Entrez Gene)
Slc5a9GeneProduct366441 (Entrez Gene)
SorbitolMetaboliteHMDB00247 (HMDB)
SordGeneProduct24788 (Entrez Gene)
TkfcGeneProduct361730 (Entrez Gene)
Tpi1GeneProduct24849 (Entrez Gene)

Annotated Interactions

<cite>No annotated interactions</cite>