Angiotensin II signaling (acute) in thick ascending limbs (Rattus norvegicus)

From WikiPathways
Jump to: navigation, search
Akt2 / PKB Akt1 / PKB Akt3 / PKB cGMP Signaling PIP2 Superoxide Ca2+ PKCa IP3 cAMP Mas1 DAG AT2R PKA NO PI3K Itpr3 Itpr1 Itpr2 PLC g2 PLC g1 AT1a AT1b G alfa-Q G alfa-11 AT1R AP B-Arrestin 2 Dynamin 1 Dynamin 2 Ca2+ PIP2 PIP3 PTEN NOS3 Calmodulin 1 Calmodulin 2 Calmodulin 3 NOX4 Rac1 DECREASED Transport Rates INCREASED Transport Rates PKCa PKCg INCREASED Transport Rates AMP PDE 2a Uncoupled NOSs PDPK1 DECREASED Transport Rates PLA2 AA 20-HETE cit-P450 Name: Angiotensin II signaling (acute) in thick ascending limbs Organism: Rattus norvegicus


The thick ascending limb of the loop pf Henle reabsorbs 25 to 30 % of the NaCl filtered through the glomerulus. Abnormally elevated Na reabsorption by this segment is link to salt-sensitive hypertension. Ang II is an important regulator of transport in the thick ascending limb, in part due to its modulatory effects on the balance between nitric oxide and superoxide. This pathway features the acute effects of Ang II in NO and O2- production in thick ascending limb. The information presented here is based on both genomic and physiological data.

Quality Tags

Ontology Terms



  1. Stempelj M, Kedinger M, Augenlicht L, Klampfer L; ''Essential role of the JAK/STAT1 signaling pathway in the expression of inducible nitric-oxide synthase in intestinal epithelial cells and its regulation by butyrate.''; J Biol Chem, 2007 PubMed
  2. Karlson U, Pejler G, Tomasini-Johansson B, Hellman L; ''Extended substrate specificity of rat mast cell protease 5, a rodent alpha-chymase with elastase-like primary specificity.''; J Biol Chem, 2003 PubMed
  3. Amlal H, LeGoff C, Vernimmen C, Soleimani M, Paillard M, Bichara M; ''ANG II controls Na(+)-K+(NH4+)-2Cl- cotransport via 20-HETE and PKC in medullary thick ascending limb.''; Am J Physiol, 1998 PubMed
  4. Rafiq K, Kolpakov MA, Abdelfettah M, Streblow DN, Hassid A, Dell'Italia LJ, Sabri A; ''Role of protein-tyrosine phosphatase SHP2 in focal adhesion kinase down-regulation during neutrophil cathepsin G-induced cardiomyocytes anoikis.''; J Biol Chem, 2006 PubMed
  5. Meister B, Lippoldt A, Bunnemann B, Inagami T, Ganten D, Fuxe K; ''Cellular expression of angiotensin type-1 receptor mRNA in the kidney.''; Kidney Int, 1993 PubMed
  6. Tikellis C, Johnston CI, Forbes JM, Burns WC, Burrell LM, Risvanis J, Cooper ME; ''Characterization of renal angiotensin-converting enzyme 2 in diabetic nephropathy.''; Hypertension, 2003 PubMed
  7. Silva GB, Garvin JL; ''Rac1 mediates NaCl-induced superoxide generation in the thick ascending limb.''; Am J Physiol Renal Physiol, 2010 PubMed
  8. Kramar EA, Armstrong DL, Ikeda S, Wayner MJ, Harding JW, Wright JW; ''The effects of angiotensin IV analogs on long-term potentiation within the CA1 region of the hippocampus in vitro.''; Brain Res, 2001 PubMed
  9. Oliveira V, Garrido PA, Rodrigues CC, Colquhoun A, Castro LM, Almeida PC, Shida CS, Juliano MA, Juliano L, Camargo AC, Hyslop S, Roberts JL, Grum-Tokars V, Glucksman MJ, Ferro ES; ''Calcium modulates endopeptidase 24.15 (EC membrane association, secondary structure and substrate specificity.''; FEBS J, 2005 PubMed
  10. Bertazolli-Filho R, Coca-Prados M, Haddad A, Laicine EM; ''Molecular analysis of neurolysin expression in the rat and bovine ciliary body.''; Curr Eye Res, 2007 PubMed
  11. Bouallegue A, Daou GB, Srivastava AK; ''Nitric oxide attenuates endothelin-1-induced activation of ERK1/2, PKB, and Pyk2 in vascular smooth muscle cells by a cGMP-dependent pathway.''; Am J Physiol Heart Circ Physiol, 2007 PubMed
  12. Poumarat JS, Houillier P, Rismondo C, Roques B, Lazar G, Paillard M, Blanchard A; ''The luminal membrane of rat thick limb expresses AT1 receptor and aminopeptidase activities.''; Kidney Int, 2002 PubMed
  13. Schmid C, Ghirlanda-Keller C, Gosteli-Peter M; ''Ascorbic acid decreases neutral endopeptidase activity in cultured osteoblastic cells.''; Regul Pept, 2005 PubMed
  14. Li N, Yi FX, Spurrier JL, Bobrowitz CA, Zou AP; ''Production of superoxide through NADH oxidase in thick ascending limb of Henle's loop in rat kidney.''; Am J Physiol Renal Physiol, 2002 PubMed
  15. Pilar Carrera M, Ramirez-Exposito MJ, Duenas B, Dolores Mayas M, Jesus Garcia M, De la Chica S, Cortes P, Ruiz-Sanjuan M, Martinez-Martos JM; ''Insulin-regulated aminopeptidase/placental leucil Aminopeptidase (IRAP/P-lAP) and angiotensin IV-forming activities are modified in serum of rats with breast cancer induced by N-methyl-nitrosourea.''; Anticancer Res, 2006 PubMed
  16. Gillis LD, Pendley DS, Funkhouser JD; ''The major APN transcript of the alveolar type II epithelial cell originates from a unique upstream promoter region.''; Biochim Biophys Acta, 1998 PubMed
  17. Neves LA, Stovall K, Joyner J, Valdes G, Gallagher PE, Ferrario CM, Merrill DC, Brosnihan KB; ''ACE2 and ANG-(1-7) in the rat uterus during early and late gestation.''; Am J Physiol Regul Integr Comp Physiol, 2008 PubMed
  18. Zhang J, Anastasiadis PZ, Liu Y, Thompson EA, Fields AP; ''Protein kinase C (PKC) betaII induces cell invasion through a Ras/Mek-, PKC iota/Rac 1-dependent signaling pathway.''; J Biol Chem, 2004 PubMed
  19. Sadjadi J, Kramer GL, Yu CH, Burress Welborn M 3rd, Chappell MC, Gregory Modrall J; ''Angiotensin converting enzyme-independent angiotensin ii production by chymase is up-regulated in the ischemic kidney in renovascular hypertension.''; J Surg Res, 2005 PubMed
  20. Ahmed MM, Arif M, Chikuma T, Kato T; ''Pentylenetetrazol-induced seizures affect the levels of prolyl oligopeptidase, thimet oligopeptidase and glial proteins in rat brain regions, and attenuation by MK-801 pretreatment.''; Neurochem Int, 2005 PubMed
  21. Uematsu F, Takahashi M, Yoshida M, Igarashi M, Nakae D; ''Methylation of neutral endopeptidase 24.11 promoter in rat hepatocellular carcinoma.''; Cancer Sci, 2006 PubMed
  22. Tsai CT, Lai LP, Kuo KT, Hwang JJ, Hsieh CS, Hsu KL, Tseng CD, Tseng YZ, Chiang FT, Lin JL; ''Angiotensin II activates signal transducer and activators of transcription 3 via Rac1 in atrial myocytes and fibroblasts: implication for the therapeutic effect of statin in atrial structural remodeling.''; Circulation, 2008 PubMed
  23. Brown CK, Madauss K, Lian W, Beck MR, Tolbert WD, Rodgers DW; ''Structure of neurolysin reveals a deep channel that limits substrate access.''; Proc Natl Acad Sci U S A, 2001 PubMed
  24. Lerolle N, Bourgeois S, Leviel F, Lebrun G, Paillard M, Houillier P; ''Angiotensin II inhibits NaCl absorption in the rat medullary thick ascending limb.''; Am J Physiol Renal Physiol, 2004 PubMed
  25. Sundberg-Smith LJ, Doherty JT, Mack CP, Taylor JM; ''Adhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylation.''; J Biol Chem, 2005 PubMed
  26. Chappell MC, Gomez MN, Pirro NT, Ferrario CM; ''Release of angiotensin-(1-7) from the rat hindlimb: influence of angiotensin-converting enzyme inhibition.''; Hypertension, 2000 PubMed
  27. Liao H, Keller SR, Castle JD; ''Insulin-regulated aminopeptidase marks an antigen-stimulated recycling compartment in mast cells.''; Traffic, 2006 PubMed
  28. Li W, Moore MJ, Vasilieva N, Sui J, Wong SK, Berne MA, Somasundaran M, Sullivan JL, Luzuriaga K, Greenough TC, Choe H, Farzan M; ''Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus.''; Nature, 2003 PubMed
  29. Wu P, Wang M, Luan H, Li L, Wang L, Wang WH, Gu R; ''Angiotensin II stimulates basolateral 10-pS Cl channels in the thick ascending limb.''; Hypertension, 2013 PubMed
  30. Oya M, Mikami S, Mizuno R, Marumo K, Mukai M, Murai M; ''C-jun activation in acquired cystic kidney disease and renal cell carcinoma.''; J Urol, 2005 PubMed
  31. Funkhouser JD, Tangada SD, Jones M, O SJ, Peterson RD; ''p146 type II alveolar epithelial cell antigen is identical to aminopeptidase N.''; Am J Physiol, 1991 PubMed
  32. Herschkovitz A, Liu YF, Ilan E, Ronen D, Boura-Halfon S, Zick Y; ''Common inhibitory serine sites phosphorylated by IRS-1 kinases, triggered by insulin and inducers of insulin resistance.''; J Biol Chem, 2007 PubMed
  33. Olson ER, Shamhart PE, Naugle JE, Meszaros JG; ''Angiotensin II-induced extracellular signal-regulated kinase 1/2 activation is mediated by protein kinase Cdelta and intracellular calcium in adult rat cardiac fibroblasts.''; Hypertension, 2008 PubMed
  34. Manser E, Leung T, Salihuddin H, Zhao ZS, Lim L; ''A brain serine/threonine protein kinase activated by Cdc42 and Rac1.''; Nature, 1994 PubMed
  35. Paliege A, Pasumarthy A, Mizel D, Yang T, Schnermann J, Bachmann S; ''Effect of apocynin treatment on renal expression of COX-2, NOS1, and renin in Wistar-Kyoto and spontaneously hypertensive rats.''; Am J Physiol Regul Integr Comp Physiol, 2006 PubMed
  36. Carini R, Alchera E, Baldanzi G, Piranda D, Splendore R, Grazia De Cesaris M, Caraceni P, Graziani A, Albano E; ''Role of p38 map kinase in glycine-induced hepatocyte resistance to hypoxic injury.''; J Hepatol, 2007 PubMed
  37. Li C, Wang X, Vais H, Thompson CB, Foskett JK, White C; ''Apoptosis regulation by Bcl-x(L) modulation of mammalian inositol 1,4,5-trisphosphate receptor channel isoform gating.''; Proc Natl Acad Sci U S A, 2007 PubMed
  38. Hong NJ, Garvin JL; ''NADPH oxidase 4 mediates flow-induced superoxide production in thick ascending limbs.''; Am J Physiol Renal Physiol, 2012 PubMed
  39. Trask AJ, Averill DB, Ganten D, Chappell MC, Ferrario CM; ''Primary role of angiotensin-converting enzyme-2 in cardiac production of angiotensin-(1-7) in transgenic Ren-2 hypertensive rats.''; Am J Physiol Heart Circ Physiol, 2007 PubMed
  40. Dauch P, Vincent JP, Checler F; ''Molecular cloning and expression of rat brain endopeptidase''; J Biol Chem, 1995 PubMed
  41. Leskinen MJ, Heikkila HM, Speer MY, Hakala JK, Laine M, Kovanen PT, Lindstedt KA; ''Mast cell chymase induces smooth muscle cell apoptosis by disrupting NF-kappaB-mediated survival signaling.''; Exp Cell Res, 2006 PubMed
  42. Deng AY, Rapp JP; ''Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat.''; J Clin Invest, 1995 PubMed
  43. Harris EL, Phelan EL, Thompson CM, Millar JA, Grigor MR; ''Heart mass and blood pressure have separate genetic determinants in the New Zealand genetically hypertensive (GH) rat.''; J Hypertens, 1995 PubMed
  44. Norman MU, Lew RA, Smith AI, Hickey MJ; ''Metalloendopeptidases EC regulate bradykinin activity in the cerebral microvasculature.''; Am J Physiol Heart Circ Physiol, 2003 PubMed
  45. Jiang Q, Gu Z, Zhang G; ''Activation, involvement and nuclear translocation of c-Jun N-terminal protein kinase 1 and 2 in glutamate-induced apoptosis in cultured rat cortical neurons.''; Brain Res, 2002 PubMed
  46. Guo Z, Jiang H, Xu X, Duan W, Mattson MP; ''Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization.''; J Biol Chem, 2008 PubMed
  47. Inukai T, Osuka K, Takagi T, Usuda N, Yoshida J, Takayasu M; ''Activation of c-jun in the rat basilar artery after subarachnoid hemorrhage.''; Neurosci Lett, 2007 PubMed
  48. Ide H, Itoh H, Tomita M, Murakumo Y, Kobayashi T, Maruyama H, Osada Y, Nawa Y; ''Cloning of the cDNA encoding a novel rat mast-cell proteinase, rMCP-3, and its expression in comparison with other rat mast-cell proteinases.''; Biochem J, 1995 PubMed
  49. Fu YC, Yin SC, Chi CS, Hwang B, Hsu SL; ''Norepinephrine induces apoptosis in neonatal rat endothelial cells via a ROS-dependent JNK activation pathway.''; Apoptosis, 2006 PubMed
  50. Watt VM, Yip CC; ''Amino acid sequence deduced from a rat kidney cDNA suggests it encodes the Zn-peptidase aminopeptidase N.''; J Biol Chem, 1989 PubMed
  51. Bouby N, Hus-Citharel A, Marchetti J, Bankir L, Corvol P, Llorens-Cortes C; ''Expression of type 1 angiotensin II receptor subtypes and angiotensin II-induced calcium mobilization along the rat nephron.''; J Am Soc Nephrol, 1997 PubMed
  52. Sleat DE, Sohar I, Lackland H, Majercak J, Lobel P; ''Rat brain contains high levels of mannose-6-phosphorylated glycoproteins including lysosomal enzymes and palmitoyl-protein thioesterase, an enzyme implicated in infantile neuronal lipofuscinosis.''; J Biol Chem, 1996 PubMed
  53. Towler P, Staker B, Prasad SG, Menon S, Tang J, Parsons T, Ryan D, Fisher M, Williams D, Dales NA, Patane MA, Pantoliano MW; ''ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis.''; J Biol Chem, 2004 PubMed
  54. Herath CB, Warner FJ, Lubel JS, Dean RG, Jia Z, Lew RA, Smith AI, Burrell LM, Angus PW; ''Upregulation of hepatic angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1-7) levels in experimental biliary fibrosis.''; J Hepatol, 2007 PubMed
  55. Rivera P, Ocaranza MP, Lavandero S, Jalil JE; ''Rho kinase activation and gene expression related to vascular remodeling in normotensive rats with high angiotensin I converting enzyme levels.''; Hypertension, 2007 PubMed
  56. Malfroy B, Schofield PR, Kuang WJ, Seeburg PH, Mason AJ, Henzel WJ; ''Molecular cloning and amino acid sequence of rat enkephalinase.''; Biochem Biophys Res Commun, 1987 PubMed
  57. Veerappan A, Reid AC, Estephan R, O'Connor N, Thadani-Mulero M, Salazar-Rodriguez M, Levi R, Silver RB; ''Mast cell renin and a local renin-angiotensin system in the airway: role in bronchoconstriction.''; Proc Natl Acad Sci U S A, 2008 PubMed
  58. Mustonen H, Hietaranta A, Puolakkainen P, Kemppainen E, Paimela H, Kiviluoto T, Kivilaakso E; ''Ethanol induced NF-{kappa}B activation protects against cell injury in cultured rat gastric mucosal epithelium.''; Am J Physiol Gastrointest Liver Physiol, 2007 PubMed
  59. Huffman LC, Koch SE, Butler KL; ''Coronary effluent from a preconditioned heart activates the JAK-STAT pathway and induces cardioprotection in a donor heart.''; Am J Physiol Heart Circ Physiol, 2008 PubMed
  60. Hodges RR, Rios JD, Vrouvlianis J, Ota I, Zoukhri D, Dartt DA; ''Roles of protein kinase C, Ca2+, Pyk2, and c-Src in agonist activation of rat lacrimal gland p42/p44 MAPK.''; Invest Ophthalmol Vis Sci, 2006 PubMed
  61. Palm F, Connors SG, Mendonca M, Welch WJ, Wilcox CS; ''Angiotensin II type 2 receptors and nitric oxide sustain oxygenation in the clipped kidney of early Goldblatt hypertensive rats.''; Hypertension, 2008 PubMed
  62. Hamilton TA, Handa RK, Harding JW, Wright JW; ''A role for the angiotensin IV/AT4 system in mediating natriuresis in the rat.''; Peptides, 2001 PubMed
  63. Russo A, Russo G, Peticca M, Pietropaolo C, Di Rosa M, Iuvone T; ''Inhibition of granuloma-associated angiogenesis by controlling mast cell mediator release: role of mast cell protease-5.''; Br J Pharmacol, 2005 PubMed
  64. Hong NJ, Silva GB, Garvin JL; ''PKC-alpha mediates flow-stimulated superoxide production in thick ascending limbs.''; Am J Physiol Renal Physiol, 2010 PubMed
  65. Bateman RC Jr, Jackson D, Slaughter CA, Unnithan S, Chai YG, Moomaw C, Hersh LB; ''Identification of the active-site arginine in rat neutral endopeptidase 24.11 (enkephalinase) as arginine 102 and analysis of a glutamine 102 mutant.''; J Biol Chem, 1989 PubMed
  66. Seyfried J, Wullner U; ''Inhibition of thioredoxin reductase induces apoptosis in neuronal cell lines: role of glutathione and the MKK4/JNK pathway.''; Biochem Biophys Res Commun, 2007 PubMed
  67. Ohkubo H, Nakayama K, Tanaka T, Nakanishi S; ''Tissue distribution of rat angiotensinogen mRNA and structural analysis of its heterogeneity.''; J Biol Chem, 1986 PubMed
  68. Nguyen G; ''Renin/prorenin receptors.''; Kidney Int, 2006 PubMed
  69. Takeda Y, Zhu A, Yoneda T, Usukura M, Takata H, Yamagishi M; ''Effects of aldosterone and angiotensin II receptor blockade on cardiac angiotensinogen and angiotensin-converting enzyme 2 expression in Dahl salt-sensitive hypertensive rats.''; Am J Hypertens, 2007 PubMed
  70. Abdelmohsen K, Sauerbier E, Ale-Agha N, Beier J, Walter P, Galban S, Stuhlmann D, Sies H, Klotz LO; ''Epidermal growth factor- and stress-induced loss of gap junctional communication is mediated by ERK-1/ERK-2 but not ERK-5 in rat liver epithelial cells.''; Biochem Biophys Res Commun, 2007 PubMed
  71. Jeske NA, Berg KA, Cousins JC, Ferro ES, Clarke WP, Glucksman MJ, Roberts JL; ''Modulation of bradykinin signaling by EP24.15 and EP24.16 in cultured trigeminal ganglia.''; J Neurochem, 2006 PubMed
  72. van den Brink OW, Delbridge LM, Pedrazzini T, Rosenfeldt FL, Pepe S; ''Augmented myocardial methionine-enkephalin in a murine model of cardiac angiotensin II-overexpression.''; J Renin Angiotensin Aldosterone Syst, 2007 PubMed
  73. Mukoyama M, Nakajima M, Horiuchi M, Sasamura H, Pratt RE, Dzau VJ; ''Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors.''; J Biol Chem, 1993 PubMed
  74. Zhou J, Hu G, Herring BP; ''Smooth muscle-specific genes are differentially sensitive to inhibition by Elk-1.''; Mol Cell Biol, 2005 PubMed
  75. Levrand S, Pesse B, Feihl F, Waeber B, Pacher P, Rolli J, Schaller MD, Liaudet L; ''Peroxynitrite is a potent inhibitor of NF-{kappa}B activation triggered by inflammatory stimuli in cardiac and endothelial cell lines.''; J Biol Chem, 2005 PubMed
  76. Cali JJ, Zwaagstra JC, Mons N, Cooper DM, Krupinski J; ''Type VIII adenylyl cyclase. A Ca2+/calmodulin-stimulated enzyme expressed in discrete regions of rat brain.''; J Biol Chem, 1994 PubMed
  77. Fernando RN, Larm J, Albiston AL, Chai SY; ''Distribution and cellular localization of insulin-regulated aminopeptidase in the rat central nervous system.''; J Comp Neurol, 2005 PubMed
  78. Good DW, George T, Wang DH; ''Angiotensin II inhibits HCO-3 absorption via a cytochrome P-450-dependent pathway in MTAL.''; Am J Physiol, 1999 PubMed
  79. Cai Y, Stafford LJ, Bryan BA, Mitchell D, Liu M; ''G-protein-activated phospholipase C-beta, new partners for cell polarity proteins Par3 and Par6.''; Oncogene, 2005 PubMed
  80. Fukamizu A, Nishi K, Cho T, Saitoh M, Nakayama K, Ohkubo H, Nakanishi S, Murakami K; ''Structure of the rat renin gene.''; J Mol Biol, 1988 PubMed
  81. Thoidis G, Kandror KV; ''A Glut4-vesicle marker protein, insulin-responsive aminopeptidase, is localized in a novel vesicular compartment in PC12 cells.''; Traffic, 2001 PubMed
  82. Gonzalez-Vicente A, Cabral PD, Garvin JL; ''Resveratrol increases nitric oxide production in the rat thick ascending limb via Ca2+/calmodulin.''; PLoS One, 2014 PubMed
  83. Tada M, Fukamizu A, Seo MS, Takahashi S, Murakami K; ''Nucleotide sequence of rat renin cDNA.''; Nucleic Acids Res, 1988 PubMed
  84. Ocaranza MP, Godoy I, Jalil JE, Varas M, Collantes P, Pinto M, Roman M, Ramirez C, Copaja M, Diaz-Araya G, Castro P, Lavandero S; ''Enalapril attenuates downregulation of Angiotensin-converting enzyme 2 in the late phase of ventricular dysfunction in myocardial infarcted rat.''; Hypertension, 2006 PubMed
  85. Deng AY, Dene H, Rapp JP; ''Mapping of a quantitative trait locus for blood pressure on rat chromosome 2.''; J Clin Invest, 1994 PubMed
  86. Silva GB, Juncos LI, Baigorria ST, Garcia NH; ''Angiotensin II inhibits ADH-stimulated cAMP: role on O2- and transport-related oxygen consumption in the loop of Henle.''; J Biol Regul Homeost Agents, 2013 PubMed
  87. Hu MC, Wang YP, Mikhail A, Qiu WR, Tan TH; ''Murine p38-delta mitogen-activated protein kinase, a developmentally regulated protein kinase that is activated by stress and proinflammatory cytokines.''; J Biol Chem, 1999 PubMed
  88. Brosnihan KB, Neves LA, Joyner J, Averill DB, Chappell MC, Sarao R, Penninger J, Ferrario CM; ''Enhanced renal immunocytochemical expression of ANG-(1-7) and ACE2 during pregnancy.''; Hypertension, 2003 PubMed
  89. Lee HJ, Tomioka M, Takaki Y, Masumoto H, Saido TC; ''Molecular cloning and expression of aminopeptidase A isoforms from rat hippocampus.''; Biochim Biophys Acta, 2000 PubMed
  90. Stragier B, Demaegdt H, De Bundel D, Smolders I, Sarre S, Vauquelin G, Ebinger G, Michotte Y, Vanderheyden P; ''Involvement of insulin-regulated aminopeptidase and/or aminopeptidase N in the angiotensin IV-induced effect on dopamine release in the striatum of the rat.''; Brain Res, 2007 PubMed
  91. Polk WW, Ellis ME, Kushleika JV, Simmonds PL, Woods JS; ''RhoA regulation of NF-kappaB activation is mediated by COX-2-dependent feedback inhibition of IKK in kidney epithelial cells.''; Am J Physiol Cell Physiol, 2007 PubMed
  92. Keller SR, Scott HM, Mastick CC, Aebersold R, Lienhard GE; ''Cloning and characterization of a novel insulin-regulated membrane aminopeptidase from Glut4 vesicles.''; J Biol Chem, 1995 PubMed
  93. Silva GB, Ortiz PA, Hong NJ, Garvin JL; ''Superoxide stimulates NaCl absorption in the thick ascending limb via activation of protein kinase C.''; Hypertension, 2006 PubMed
  94. Sampaio WO, Souza dos Santos RA, Faria-Silva R, da Mata Machado LT, Schiffrin EL, Touyz RM; ''Angiotensin-(1-7) through receptor Mas mediates endothelial nitric oxide synthase activation via Akt-dependent pathways.''; Hypertension, 2007 PubMed
  95. Kim JS, Jobin C; ''The flavonoid luteolin prevents lipopolysaccharide-induced NF-kappaB signalling and gene expression by blocking IkappaB kinase activity in intestinal epithelial cells and bone-marrow derived dendritic cells.''; Immunology, 2005 PubMed
  96. Sanchez-Lopez E, Rodriguez-Vita J, Cartier C, Ruperez M, Esteban V, Carvajal G, Rodrigues-Diez R, Plaza JJ, Egido J, Ruiz-Ortega M; ''Inhibitory effect of interleukin-1beta on angiotensin II-induced connective tissue growth factor and type IV collagen production in cultured mesangial cells.''; Am J Physiol Renal Physiol, 2008 PubMed
  97. Rettig R, Healy DP, Printz MP; ''Cardiovascular effects of microinjections of angiotensin II into the nucleus tractus solitarii.''; Brain Res, 1986 PubMed
  98. Cole KR, Kumar S, Trong HL, Woodbury RG, Walsh KA, Neurath H; ''Rat mast cell carboxypeptidase: amino acid sequence and evidence of enzyme activity within mast cell granules.''; Biochemistry, 1991 PubMed
  99. Kreutz R, Huebner N, Ganten D, Lindpaintner K; ''Genetic linkage of the ACE gene to plasma angiotensin-converting enzyme activity but not to blood pressure. A quantitative trait locus confers identical complex phenotypes in human and rat hypertension.''; Circulation, 1995 PubMed
  100. ''''; , PubMed
  101. Hong NJ, Garvin JL; ''Nitric oxide reduces flow-induced superoxide production via cGMP-dependent protein kinase in thick ascending limbs.''; Am J Physiol Renal Physiol, 2009 PubMed
  102. McCool S, Pierotti AR; ''Expression of the thimet oligopeptidase gene is regulated by positively and negatively acting elements.''; DNA Cell Biol, 2000 PubMed
  103. Whaley-Connell A, Govindarajan G, Habibi J, Hayden MR, Cooper SA, Wei Y, Ma L, Qazi M, Link D, Karuparthi PR, Stump C, Ferrario C, Sowers JR; ''Angiotensin II-mediated oxidative stress promotes myocardial tissue remodeling in the transgenic (mRen2) 27 Ren2 rat.''; Am J Physiol Endocrinol Metab, 2007 PubMed
  104. Malfroy B, Kado-Fong H, Gros C, Giros B, Schwartz JC, Hellmiss R; ''Molecular cloning and amino acid sequence of rat kidney aminopeptidase M: a member of a super family of zinc-metallohydrolases.''; Biochem Biophys Res Commun, 1989 PubMed
  105. Song L, Ye M, Troyanovskaya M, Wilk E, Wilk S, Healy DP; ''Rat kidney glutamyl aminopeptidase (aminopeptidase A): molecular identity and cellular localization.''; Am J Physiol, 1994 PubMed
  106. Cerezo-Guisado MI, Alvarez-Barrientos A, Argent R, Garcia-Marin LJ, Bragado MJ, Lorenzo MJ; ''c-Jun N-terminal protein kinase signalling pathway mediates lovastatin-induced rat brain neuroblast apoptosis.''; Biochim Biophys Acta, 2007 PubMed
  107. Bjork P, Ohlsson K; ''Purification and N-terminal amino-acid sequence analysis of rat polymorphonuclear leukocyte cathepsin G.''; Biol Chem Hoppe Seyler, 1990 PubMed
  108. Heikkila HM, Lutti S, Leskinen MJ, Hakala JK, Kovanen PT, Lindstedt KA; ''Activated mast cells induce endothelial cell apoptosis by a combined action of chymase and tumor necrosis factor-alpha.''; Arterioscler Thromb Vasc Biol, 2008 PubMed
  109. Kyriakis JM, Banerjee P, Nikolakaki E, Dai T, Rubie EA, Ahmad MF, Avruch J, Woodgett JR; ''The stress-activated protein kinase subfamily of c-Jun kinases.''; Nature, 1994 PubMed
  110. Banes-Berceli AK, Ketsawatsomkron P, Ogbi S, Patel B, Pollock DM, Marrero MB; ''Angiotensin II and endothelin-1 augment the vascular complications of diabetes via JAK2 activation.''; Am J Physiol Heart Circ Physiol, 2007 PubMed
  111. Hong NJ, Garvin JL; ''Angiotensin II type 2 receptor-mediated inhibition of NaCl absorption is blunted in thick ascending limbs from Dahl salt-sensitive rats.''; Hypertension, 2012 PubMed
  112. Healy DP, Printz MP; ''Angiotensinogen levels in the brain and cerebrospinal fluid of the genetically hypertensive rat.''; Hypertension, 1985 PubMed
  113. Deng Y, Rapp JP; ''Cosegregation of blood pressure with angiotensin converting enzyme and atrial natriuretic peptide receptor genes using Dahl salt-sensitive rats.''; Nat Genet, 1992 PubMed
  114. Kokkinos MI, Brown HJ, de Iongh RU; ''Focal adhesion kinase (FAK) expression and activation during lens development.''; Mol Vis, 2007 PubMed
  115. Carrera MP, Ramirez-Exposito MJ, Valenzuela MT, Duenas B, Garcia MJ, Mayas MD, Martinez-Martos JM; ''Renin-angiotensin system-regulating aminopeptidase activities are modified in the pineal gland of rats with breast cancer induced by N-methyl-nitrosourea.''; Cancer Invest, 2006 PubMed
  116. Aiello S, Cassis P, Cassis L, Tomasoni S, Benigni A, Pezzotta A, Cavinato RA, Cugini D, Azzollini N, Mister M, Longaretti L, Thomson AW, Remuzzi G, Noris M; ''DnIKK2-transfected dendritic cells induce a novel population of inducible nitric oxide synthase-expressing CD4+CD25- cells with tolerogenic properties.''; Transplantation, 2007 PubMed
  117. Khurana A, Dey CS; ''Involvement of Elk-1 in L6E9 skeletal muscle differentiation.''; FEBS Lett, 2002 PubMed
  118. Crackower MA, Sarao R, Oudit GY, Yagil C, Kozieradzki I, Scanga SE, Oliveira-dos-Santos AJ, da Costa J, Zhang L, Pei Y, Scholey J, Ferrario CM, Manoukian AS, Chappell MC, Backx PH, Yagil Y, Penninger JM; ''Angiotensin-converting enzyme 2 is an essential regulator of heart function.''; Nature, 2002 PubMed
  119. Jacob HJ, Lindpaintner K, Lincoln SE, Kusumi K, Bunker RK, Mao YP, Ganten D, Dzau VJ, Lander ES; ''Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat.''; Cell, 1991 PubMed
  120. Herrera M, Garvin JL; ''Angiotensin II stimulates thick ascending limb NO production via AT(2) receptors and Akt1-dependent nitric-oxide synthase 3 (NOS3) activation.''; J Biol Chem, 2010 PubMed
  121. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA; ''Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.''; Proc Natl Acad Sci U S A, 2002 PubMed
  122. Augustyniak RA, Maliszewska-Scislo M, Chen H, Fallucca J, Rossi NF; ''Acute angiotensin-converting enzyme inhibition evokes bradykinin-induced sympathetic activation in diabetic rats.''; Am J Physiol Regul Integr Comp Physiol, 2007 PubMed
  123. Wang SF, Liang Q, Li GW, Gao K; ''Gene expression profile in rat small intestinal allografts after cold preservation/reperfusion.''; World J Gastroenterol, 2005 PubMed
  124. Silva GB, Garvin JL; ''Akt1 mediates purinergic-dependent NOS3 activation in thick ascending limbs.''; Am J Physiol Renal Physiol, 2009 PubMed
  125. Siragy HM, Inagami T, Carey RM; ''NO and cGMP mediate angiotensin AT2 receptor-induced renal renin inhibition in young rats.''; Am J Physiol Regul Integr Comp Physiol, 2007 PubMed
  126. Norman MU, Reeve SB, Dive V, Smith AI, Lew RA; ''Endopeptidases and 24.16 in endothelial cells: potential role in vasoactive peptide metabolism.''; Am J Physiol Heart Circ Physiol, 2003 PubMed
  127. Kim SO, Irwin P, Katz S, Pelech SL; ''Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart.''; J Cell Biochem, 1998 PubMed
  128. Kotlo K, Hughes DE, Herrera VL, Ruiz-Opazo N, Costa RH, Robey RB, Danziger RS; ''Functional polymorphism of the Anpep gene increases promoter activity in the Dahl salt-resistant rat.''; Hypertension, 2007 PubMed
  129. Laes JF, Ravoet M, Quan X, Van Vooren P, Szpirer J, Szpirer C; ''Improved radiation hybrid map of rat chromosome 2: colocalization of the genes encoding corticotropin-releasing hormone and IL6-receptor with quantitative trait loci regulating the inflammatory response.''; Cytogenet Cell Genet, 2001 PubMed
  130. Hong NJ, Garvin JL; ''Endogenous flow-induced superoxide stimulates Na/H exchange activity via PKC in thick ascending limbs.''; Am J Physiol Renal Physiol, 2014 PubMed
  131. Fraga-Silva RA, Pinheiro SV, Goncalves AC, Alenina N, Bader M, Santos RA; ''The antithrombotic effect of angiotensin-(1-7) involves mas-mediated NO release from platelets.''; Mol Med, 2008 PubMed
  132. Reudelhuber TL; ''The renin-angiotensin system: peptides and enzymes beyond angiotensin II.''; Curr Opin Nephrol Hypertens, 2005 PubMed
  133. Ronchi FA, Irigoyen MC, Casarini DE; ''Association of somatic and N-domain angiotensin-converting enzymes from Wistar rat tissue with renal dysfunction in diabetes mellitus.''; J Renin Angiotensin Aldosterone Syst, 2007 PubMed
  134. Tronik D, Ekker M, Rougeon F; ''Structural analysis of 5'-flanking regions of rat, mouse and human renin genes reveals the presence of a transposable-like element in the two mouse genes.''; Gene, 1988 PubMed
  135. de Gortari P, Vargas MA, Martinez A, Garcia-Vazquez AI, Uribe RM, Chavez-Gutierrez L, Magdaleno V, Boileau G, Charli JL, Joseph-Bravo P; ''Stage-specific modulation of neprilysin and aminopeptidase N in the limbic system during kindling progression.''; J Mol Neurosci, 2007 PubMed
  136. Vlahovic P, Cvetkovic T, Nikolic J, Sokolovic D; ''Ethanol inhibitory effect on rat kidney brush border aminopeptidases.''; Nephron Exp Nephrol, 2007 PubMed
  137. Ballard-Croft C, Locklar AC, Keith BJ, Mentzer RM Jr, Lasley RD; ''Oxidative stress and adenosine A1 receptor activation differentially modulate subcellular cardiomyocyte MAPKs.''; Am J Physiol Heart Circ Physiol, 2008 PubMed
  138. Butterfield L, Zentrich E, Beekman A, Heasley LE; ''Stress- and cell type-dependent regulation of transfected c-Jun N-terminal kinase and mitogen-activated protein kinase kinase isoforms.''; Biochem J, 1999 PubMed
  139. Pierotti A, Dong KW, Glucksman MJ, Orlowski M, Roberts JL; ''Molecular cloning and primary structure of rat testes metalloendopeptidase EC''; Biochemistry, 1990 PubMed
  140. Leckie BJ; ''Targeting the renin-angiotensin system: what's new?''; Curr Med Chem Cardiovasc Hematol Agents, 2005 PubMed
  141. Waetzig V, Herdegen T; ''MEKK1 controls neurite regrowth after experimental injury by balancing ERK1/2 and JNK2 signaling.''; Mol Cell Neurosci, 2005 PubMed
  142. Zhang Y, Zhang H, Yuan X, Gu X; ''Differential effects of phenylalanine on Rac1, Cdc42, and RhoA expression and activity in cultured cortical neurons.''; Pediatr Res, 2007 PubMed
  143. Tallant EA, Ferrario CM, Gallagher PE; ''Angiotensin-(1-7) inhibits growth of cardiac myocytes through activation of the mas receptor.''; Am J Physiol Heart Circ Physiol, 2005 PubMed
  144. Wang M, Luan H, Wu P, Fan L, Wang L, Duan X, Zhang D, Wang WH, Gu R; ''Angiotensin II stimulates basolateral 50-pS K channels in the thick ascending limb.''; Am J Physiol Renal Physiol, 2014 PubMed
  145. Chaturvedi LS, Marsh HM, Shang X, Zheng Y, Basson MD; ''Repetitive deformation activates focal adhesion kinase and ERK mitogenic signals in human Caco-2 intestinal epithelial cells through Src and Rac1.''; J Biol Chem, 2007 PubMed
  146. Ray K, Hines CS, Rodgers DW; ''Mapping sequence differences between thimet oligopeptidase and neurolysin implicates key residues in substrate recognition.''; Protein Sci, 2002 PubMed
  147. Padia SH, Kemp BA, Howell NL, Fournie-Zaluski MC, Roques BP, Carey RM; ''Conversion of renal angiotensin II to angiotensin III is critical for AT2 receptor-mediated natriuresis in rats.''; Hypertension, 2008 PubMed
  148. Hong NJ, Garvin JL; ''Endogenous flow-induced nitric oxide reduces superoxide-stimulated Na/H exchange activity via PKG in thick ascending limbs.''; Am J Physiol Renal Physiol, 2015 PubMed
  149. Serizawa A, Dando PM, Barrett AJ; ''Characterization of a mitochondrial metallopeptidase reveals neurolysin as a homologue of thimet oligopeptidase.''; J Biol Chem, 1995 PubMed
  150. Leskinen MJ, Lindstedt KA, Wang Y, Kovanen PT; ''Mast cell chymase induces smooth muscle cell apoptosis by a mechanism involving fibronectin degradation and disruption of focal adhesions.''; Arterioscler Thromb Vasc Biol, 2003 PubMed
  151. Rafiq K, Hanscom M, Valerie K, Steinberg SF, Sabri A; ''Novel mode for neutrophil protease cathepsin G-mediated signaling: membrane shedding of epidermal growth factor is required for cardiomyocyte anoikis.''; Circ Res, 2008 PubMed
  152. Mori T, Cowley AW Jr; ''Angiotensin II-NAD(P)H oxidase-stimulated superoxide modifies tubulovascular nitric oxide cross-talk in renal outer medulla.''; Hypertension, 2003 PubMed
  153. Herrera M, Silva GB, Garvin JL; ''Angiotensin II stimulates thick ascending limb superoxide production via protein kinase C(α)-dependent NADPH oxidase activation.''; J Biol Chem, 2010 PubMed
  154. Morrison LS, Pierotti AR; ''Thimet oligopeptidase expression is differentially regulated in neuroendocrine and spermatid cell lines by transcription factor binding to SRY (sex-determining region Y), CAAT and CREB (cAMP-response-element-binding protein) promoter consensus sequences.''; Biochem J, 2003 PubMed
  155. Fontan E, Traincard F, Levy SG, Yamaoka S, Veron M, Agou F; ''NEMO oligomerization in the dynamic assembly of the IkappaB kinase core complex.''; FEBS J, 2007 PubMed
  156. Troyanovskaya M, Song L, Jayaraman G, Healy DP; ''Expression of aminopeptidase A, an angiotensinase, in glomerular mesangial cells.''; Hypertension, 1996 PubMed
  157. Saito N, Courtois G, Chiba A, Yamamoto N, Nitta T, Hironaka N, Rowe M, Yamaoka S; ''Two carboxyl-terminal activation regions of Epstein-Barr virus latent membrane protein 1 activate NF-kappaB through distinct signaling pathways in fibroblast cell lines.''; J Biol Chem, 2003 PubMed
  158. Jackson EK, Gillespie DG, Zhu C, Ren J, Zacharia LC, Mi Z; ''Alpha2-adrenoceptors enhance angiotensin II-induced renal vasoconstriction: role for NADPH oxidase and RhoA.''; Hypertension, 2008 PubMed
  159. Mastick CC, Aebersold R, Lienhard GE; ''Characterization of a major protein in GLUT4 vesicles. Concentration in the vesicles and insulin-stimulated translocation to the plasma membrane.''; J Biol Chem, 1994 PubMed
  160. Lutzelschwab C, Pejler G, Aveskogh M, Hellman L; ''Secretory granule proteases in rat mast cells. Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations.''; J Exp Med, 1997 PubMed
  161. Nadruz W Jr, Kobarg CB, Kobarg J, Franchini KG; ''c-Jun is regulated by combination of enhanced expression and phosphorylation in acute-overloaded rat heart.''; Am J Physiol Heart Circ Physiol, 2004 PubMed
  162. Nakayama T, Nakajima T, Sokabe H; ''Comparative studies on angiotensins. II. Structure of rat angiotensin and its identification by DNS-method.''; Chem Pharm Bull (Tokyo), 1972 PubMed
  163. Tucker BJ, Mundy CA, Maciejewski AR, Printz MP, Ziegler MG, Pelayo JC, Blantz RC; ''Changes in glomerular hemodynamic response to angiotensin II after subacute renal denervation in rats.''; J Clin Invest, 1986 PubMed
  164. Torp M, Brønd L, Hadrup N, Nielsen JB, Praetorius J, Nielsen S, Christensen S, Jonassen TE; ''Losartan decreases vasopressin-mediated cAMP accumulation in the thick ascending limb of the loop of Henle in rats with congestive heart failure.''; Acta Physiol (Oxf), 2007 PubMed
  165. Li CH, Wang RM, Zhang QG, Zhang GY; ''Activated mitogen-activated protein kinase kinase 7 redistributes to the cytosol and binds to Jun N-terminal kinase-interacting protein 1 involving oxidative stress during early reperfusion in rat hippocampal CA1 region.''; J Neurochem, 2005 PubMed
  166. Clement N, Glorian M, Raymondjean M, Andreani M, Limon I; ''PGE2 amplifies the effects of IL-1beta on vascular smooth muscle cell de-differentiation: a consequence of the versatility of PGE2 receptors 3 due to the emerging expression of adenylyl cyclase 8.''; J Cell Physiol, 2006 PubMed
  167. Inagami T, Iwai N, Sasaki K, Yamano Y, Bardhan S, Chaki S, Guo DF, Furuta H, Ohyama K, Kambayashi Y; ''Cloning, expression and regulation of angiotensin II receptors.''; Eur Heart J, 1994 PubMed
  168. McKie N, Dando PM, Rawlings ND, Barrett AJ; ''Thimet oligopeptidase: similarity to 'soluble angiotensin II-binding protein' and some corrections to the published amino acid sequence of the rat testis enzyme.''; Biochem J, 1993 PubMed
  169. Rider L, Shatrova A, Feener EP, Webb L, Diakonova M; ''JAK2 tyrosine kinase phosphorylates PAK1 and regulates PAK1 activity and functions.''; J Biol Chem, 2007 PubMed
  170. Kishi K, Jin D, Takai S, Muramatsu M, Katayama H, Tamai H, Miyazaki M; ''Role of chymase-dependent angiotensin II formation in monocrotaline-induced pulmonary hypertensive rats.''; Pediatr Res, 2006 PubMed
  171. Martinelli I, Mainini E, Mazzi C; ''Effect of 5-hydroxytryptophan on the secretion of PRL, GH, TSH and cortisol in obesity''; Minerva Endocrinol, 1992 PubMed
  172. Burnham CE, Hawelu-Johnson CL, Frank BM, Lynch KR; ''Molecular cloning of rat renin cDNA and its gene.''; Proc Natl Acad Sci U S A, 1987 PubMed
  173. Ibarz G, Oiry C, Carnazzi E, Crespy P, Escrieut C, Fourmy D, Galleyrand JC, Gagne D, Martinez J; ''Cholecystokinin 1 receptor modulates the MEKK1-induced c-Jun trans-activation: structural requirements of the receptor.''; Br J Pharmacol, 2006 PubMed
  174. Der Sarkissian S, Grobe JL, Yuan L, Narielwala DR, Walter GA, Katovich MJ, Raizada MK; ''Cardiac overexpression of angiotensin converting enzyme 2 protects the heart from ischemia-induced pathophysiology.''; Hypertension, 2008 PubMed
  175. Massey KJ, Hong NJ, Garvin JL; ''Angiotensin II stimulates superoxide production in the thick ascending limb by activating NOX4.''; Am J Physiol Cell Physiol, 2012 PubMed
View all...


View all...
96438view 00:55, 15 March 2018EgonwReplaced a secondary ChEBI identifier with a primary identifier.
95224view 11:28, 26 November 2017DeSlAdded unconnected line.
95169view 13:11, 20 November 2017SusanAnnotated protein
95162view 10:55, 17 November 2017AgustinGVModified title
95161view 10:53, 17 November 2017AgustinGVAdding 20-HETE pw
94514view 12:11, 16 September 2017AlexanderPicoRemoved "undefined" xref values
94478view 11:45, 12 September 2017AgustinGV
94477view 11:43, 12 September 2017AgustinGV
94476view 11:35, 12 September 2017AgustinGVQuick edit to datanode annotation or property
92339view 05:32, 25 May 2017AgustinGV
92338view 05:30, 25 May 2017AgustinGVcorrect alignment
91518view 13:55, 8 March 2017Khanspersadded ids for some metabolites
91331view 11:19, 2 February 2017Khanspersconnected interactions
90426view 12:54, 15 November 2016AgustinGV
89600view 09:04, 19 September 2016AgustinGV
89588view 08:45, 19 September 2016AgustinGVOntology Term : 'kidney loop of henle thick ascending limb epithelial cell' added !
89587view 08:45, 19 September 2016AgustinGVOntology Term : 'renal hypertension' added !
89576view 08:31, 19 September 2016AgustinGVModified description
89568view 00:52, 17 September 2016EgonwReplaced an secondary HMDB id with the main ID.
89402view 12:49, 10 September 2016AlexanderPicoOntology Term : 'signaling pathway' added !
89401view 12:49, 10 September 2016AlexanderPicoOntology Term : 'angiotensin signaling pathway' added !
89248view 10:49, 25 August 2016AgustinGVSpecify description
89239view 14:35, 24 August 2016AgustinGVModified description
89214view 07:05, 23 August 2016AgustinGVSpecify description
89213view 07:03, 23 August 2016AgustinGVNew pathway

External references


View all...
NameTypeDatabase referenceComment
20-HETEMetaboliteHMDB0005998 (HMDB)
AAMetaboliteCHEBI:01043 (ChEBI)
AMPMetaboliteHMDB03540 (HMDB)
AT1R APGeneProduct298646 (Entrez Gene)
AT1aGeneProduct24180 (Entrez Gene)
AT1bGeneProduct81638 (Entrez Gene)
AT2RGeneProduct24182 (Entrez Gene)
Akt1 / PKBProtein24185 (Entrez Gene)
Akt2 / PKBProtein25233 (Entrez Gene)
Akt3 / PKBProtein29414 (Entrez Gene)
B-Arrestin 2GeneProduct25388 (Entrez Gene)
Ca2+MetaboliteHMDB00464 (HMDB)
Calmodulin 1GeneProduct24242 (Entrez Gene)
Calmodulin 2GeneProduct50663 (Entrez Gene)
Calmodulin 3GeneProduct24244 (Entrez Gene)
DAGMetaboliteCHEBI:18035 (ChEBI)
Dynamin 1 GeneProduct140694 (Entrez Gene)
Dynamin 2GeneProduct25751 (Entrez Gene)
G alfa-11GeneProduct81662 (Entrez Gene)
G alfa-QGeneProduct81666 (Entrez Gene)
IP3MetaboliteHMDB01498 (HMDB)
Itpr1GeneProduct25262 (Entrez Gene)
Itpr2GeneProduct81678 (Entrez Gene)
Itpr3GeneProduct25679 (Entrez Gene)
Mas1Protein25153 (Entrez Gene)
NOMetaboliteHMDB03378 (HMDB)
NOS3GeneProduct24600 (Entrez Gene)
NOX4GeneProduct85431 (Entrez Gene)
PDE 2aGeneProduct81743 (Entrez Gene)
PDPK1GeneProduct81745 (Entrez Gene)
PIP2Metabolite21169207 (Chemspider)
PIP3MetaboliteQ3078767 (Wikidata)
PKAProtein3389 (RGD)
PKCaGeneProduct24680 (Entrez Gene)
PKCgGeneProduct24681 (Entrez Gene)
PLC g1GeneProduct25738 (Entrez Gene)
PLC g2GeneProduct29337 (Entrez Gene)
PTENProtein50557 (Entrez Gene)
Rac1GeneProduct85431 (Entrez Gene)
SuperoxideMetaboliteHMDB02168 (HMDB)
Uncoupled NOSsGeneProduct24600 (Entrez Gene)
cAMPMetaboliteHMDB00058 (HMDB)

Annotated Interactions

<cite>No annotated interactions</cite>