Thick Ascending Limb Transporters (Rattus norvegicus)

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Luminal side NHE3 NBCn1 ROMK 2/3 NKCC2 ATP1A1 ATP1B1 Fxyd2 Na K 2 Cl K K 2 K 2 K 3 Na 3 Na Na H Na H CO2 H2O H HCO3 HCO3 Na HCO3 Na Cl Cl Barttin CLC-K2 CLC-K1 Basolateral side Na K 2 Cl KCC4 K Cl K Cl Aquaporin 1 H2O H2O CA2 CA4 CO2 H2O H HCO3 ATP ADP K Channels K K KCNK12 KCNQ1 KCNK13 KCNJ13 KCNJ16 NHE2 Name: Thick Ascending Limb Transporters Organism: Rattus norvegicus


This pathway shows the main transporters in the thick ascending limb of the Loop of Henle

Quality Tags

Ontology Terms



  1. Hebert SC, Andreoli TE; ''Control of NaCl transport in the thick ascending limb.''; Am J Physiol, 1984 PubMed
  2. Féraille E, Doucet A; ''Sodium-potassium-adenosinetriphosphatase-dependent sodium transport in the kidney: hormonal control.''; Physiol Rev, 2001 PubMed
  3. Greger R; ''Ion transport mechanisms in thick ascending limb of Henle's loop of mammalian nephron.''; Physiol Rev, 1985 PubMed
  4. Cabral PD, Herrera M; ''Membrane-associated aquaporin-1 facilitates osmotically driven water flux across the basolateral membrane of the thick ascending limb.''; Am J Physiol Renal Physiol, 2012 PubMed
  5. Mount DB; ''Thick ascending limb of the loop of Henle.''; Clin J Am Soc Nephrol, 2014 PubMed
  6. Lee JW, Chou CL, Knepper MA; ''Deep Sequencing in Microdissected Renal Tubules Identifies Nephron Segment-Specific Transcriptomes.''; J Am Soc Nephrol, 2015 PubMed
  7. Hamilton KL, Devor DC; ''Basolateral membrane K+ channels in renal epithelial cells.''; Am J Physiol Renal Physiol, 2012 PubMed
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95062view 06:12, 11 November 2017EgonwFixed character encoding.
94968view 06:48, 20 October 2017AgustinGVAdd refs
94967view 06:40, 20 October 2017AgustinGVAdd NHE2
94966view 06:39, 20 October 2017AgustinGVAdd Clcnka
94965view 06:31, 20 October 2017AgustinGVAdd gamma subunit to NKA
94964view 06:22, 20 October 2017AgustinGVUpdate Basolateral K channels
94669view 06:37, 4 October 2017AgustinGVOntology Term : 'Bartter disease' added !
91330view 11:17, 2 February 2017Khanspersconnected interactions
89594view 08:56, 19 September 2016AgustinGVOntology Term : 'kidney loop of henle thick ascending limb epithelial cell' added !
89125view 12:21, 22 August 2016KhanspersModified title
89122view 12:17, 22 August 2016KhanspersReverted to version '19:22, 18 August 2016' by Khanspers
89121view 12:17, 22 August 2016KhanspersModified title
89037view 12:22, 18 August 2016AlexanderPicoConverted interactions to graphical lines to avoid constraints and validation triggers
89036view 12:13, 18 August 2016AgustinGVRefs.
89032view 12:03, 18 August 2016MaintBotOntology Term : 'regulatory pathway' added !
89031view 12:03, 18 August 2016MaintBotOntology Term : 'transport pathway' added !
89030view 12:00, 18 August 2016AgustinGVSpecify description
89029view 11:59, 18 August 2016AgustinGVSpecify description
89027view 11:48, 18 August 2016AgustinGV
89026view 11:40, 18 August 2016AgustinGV
89025view 11:35, 18 August 2016AgustinGVUpdate CAs
89024view 11:20, 18 August 2016AgustinGVModified description
89023view 11:19, 18 August 2016AgustinGVOntology Term : 'transporting cell' added !
89022view 11:17, 18 August 2016AgustinGVOntology Term : 'kidney epithelial cell' added !
89021view 11:16, 18 August 2016AgustinGVMinor alignment
89020view 11:14, 18 August 2016AgustinGVNew pathway

External references


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NameTypeDatabase referenceComment
2 ClMetaboliteHMDB00492 (HMDB)
2 KMetaboliteHMDB00586 (HMDB)
3 NaMetaboliteHMDB00588 (HMDB)
ADPMetaboliteHMDB01341 (HMDB)
ATP1A1GeneProduct24211 (Entrez Gene)
ATP1B1GeneProduct25650 (Entrez Gene)
ATPMetaboliteHMDB00538 (HMDB)
Aquaporin 1GeneProduct25240 (Entrez Gene)
BarttinGeneProduct79430 (Entrez Gene)
CA2GeneProduct54231 (Entrez Gene)
CA4GeneProduct29242 (Entrez Gene)
CLC-K1GeneProduct79425 (Entrez Gene)
CLC-K2GeneProduct79430 (Entrez Gene)
CO2MetaboliteHMDB01967 (HMDB)
ClMetaboliteHMDB00492 (HMDB)
Fxyd2GeneProduct29639 (Entrez Gene)
H2OMetaboliteHMDB02111 (HMDB)
HCO3MetaboliteHMDB00595 (HMDB)
HMetaboliteHMDB59597 (HMDB)
K ChannelsGeneProduct
KCC4GeneProduct308069 (Entrez Gene)
KCNJ13GeneProduct94341 (Entrez Gene)
KCNJ16GeneProduct29719 (Entrez Gene)
KCNK12GeneProduct64119 (Entrez Gene)
KCNK13GeneProduct64120 (Entrez Gene)
KCNQ1GeneProduct84020 (Entrez Gene)
KMetaboliteHMDB00586 (HMDB)
NBCn1GeneProduct117955 (Entrez Gene)
NHE2GeneProduct24783 (Entrez Gene)
NHE3GeneProduct24784 (Entrez Gene)
NKCC2GeneProduct25065 (Entrez Gene)
NaMetaboliteHMDB00588 (HMDB)
ROMK 2/3GeneProduct24521 (Entrez Gene)

Annotated Interactions

<cite>No annotated interactions</cite>