Proximal Tubule Transporters (Rattus norvegicus)

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Na+ / H+ Exchange NHE3 NHE3 RegP1 NHE3 RegP2 NHE8 CA II CA VII CA IV CA XII CA XIV CA XV PAT1 SAT1 OAT1 OAT3 NaPi-2a NaPi-2b Pit-2 NAS1 NBC NaDC-1 NaDC-3 Atp1a1 Atp1b1 Atp1b3 Gamma 1 CHIF B*AT1 E. Glutam. Tr. SNAT7 LAT3-4F2hc OCTN2 BAT-1 LAT1-4F2hc LAT3-4F2hc TAT1 Atp6v1a Atp6v1b1 Atp6v1b2 Atp6v1c1 Atp6v1d Atp6v1e1 Atp6v1f Atp6v1g1 Atp6v1g3 Atp6v1h Atp6v0a1 Atp6v0a2 Atp6v0a4 Atp6v0b Atp6v0c Atp6v0d1 Atp6v0d2 Atp6v0e1 Atp6v0e2 Na-Anion Cotransport H-ATPase V0 Subunits H-ATPase V1 Subunits Carbonic Anhydrases Na/K-ATPase Subunits Anion Exchange Na-dependent Amino Acids Transport Na-independent Amino Acids Transport Name: Proximal Tubule Transporters Organism: Rattus norvegicus


The proximal tubule of the nephron reabsorbs approximately two-thirds of the Na filtered through the glomerulus. Na extrusion from the cell by the basolateral Na/K-ATPase provides the gradient for apical Na entry, and for reabsorption of glucose, phosphate, amino acids and other component of the ultrafiltrate. This pathway organizes several of the transporters present in the proximal tubule by their function and it is based in deep-sequencing and physiological data.

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Ontology Terms



  1. Curthoys NP, Moe OW; ''Proximal tubule function and response to acidosis.''; Clin J Am Soc Nephrol, 2014 PubMed
  2. Purkerson JM, Schwartz GJ; ''The role of carbonic anhydrases in renal physiology.''; Kidney Int, 2007 PubMed
  3. Markovich D, Aronson PS; ''Specificity and regulation of renal sulfate transporters.''; Annu Rev Physiol, 2007 PubMed
  4. Lee JW, Chou CL, Knepper MA; ''Deep Sequencing in Microdissected Renal Tubules Identifies Nephron Segment-Specific Transcriptomes.''; J Am Soc Nephrol, 2015 PubMed


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94666view 06:22, 4 October 2017AgustinGVOntology Term : 'kidney proximal convoluted tubule epithelial cell' added !
89611view 06:36, 20 September 2016AgustinGVModified description
89599view 09:02, 19 September 2016AgustinGVOntology Term : 'epithelial cell of proximal tubule' added !
89124view 12:21, 22 August 2016Khanspersfixing broken literature references
89123view 12:19, 22 August 2016Khanspers
89103view 07:16, 22 August 2016AgustinGVcorrect misalignment
88956view 14:18, 17 August 2016AgustinGVSpecify description
88955view 14:14, 17 August 2016AlexanderPicoMinor updates to labels and layout
88949view 14:00, 17 August 2016AgustinGVSpecify description
88948view 12:26, 17 August 2016AlexanderPicoOntology Term : 'transport pathway' added !
88947view 12:26, 17 August 2016AlexanderPicoOntology Term : 'regulatory pathway' added !
88946view 12:25, 17 August 2016AlexanderPicoOntology Term : 'ion transport pathway' added !
88945view 12:24, 17 August 2016AlexanderPicoOntology Term : 'nephron tubule epithelial cell' added !
88942view 11:39, 17 August 2016AgustinGVupdate protein to gene product
88926view 10:46, 17 August 2016AgustinGVModified description
88921view 07:45, 17 August 2016AgustinGVSpecify description
88920view 07:44, 17 August 2016AgustinGVModified description
88919view 07:41, 17 August 2016AgustinGValigment
88918view 07:39, 17 August 2016AgustinGV
88917view 07:36, 17 August 2016AgustinGVH ATPase Vo
88916view 07:33, 17 August 2016AgustinGVH ATPase V1 subs
88915view 07:31, 17 August 2016AgustinGV
88914view 07:27, 17 August 2016AgustinGV
88911view 05:35, 17 August 2016AgustinGVUpdate AA transporters
88892view 14:28, 16 August 2016AgustinGVSpecify description
88891view 14:26, 16 August 2016AgustinGVSpecify description
88890view 14:25, 16 August 2016AgustinGVSpecify description
88889view 14:20, 16 August 2016AgustinGVQuick edit to datanode annotation or property
88888view 14:17, 16 August 2016AgustinGVReferences
88887view 14:01, 16 August 2016AgustinGVQuick edit to datanode annotation or property
88882view 13:53, 16 August 2016AgustinGVModified description
88881view 13:52, 16 August 2016AgustinGVOntology Term : 'PW:0000001' removed !
88880view 13:52, 16 August 2016AgustinGVOntology Term : 'Pathway Ontology' added !
88879view 13:16, 16 August 2016AgustinGVSpecify description
88878view 13:13, 16 August 2016AgustinGVUpdate Na-Anions simporters
88877view 13:06, 16 August 2016AgustinGVUpdate Anion Exchangers
88876view 13:03, 16 August 2016AgustinGVSpecify description
88875view 13:00, 16 August 2016AgustinGVSpecify description
88874view 12:56, 16 August 2016AgustinGVPeriodical save, work in progress
88873view 12:49, 16 August 2016AgustinGVSpecify description
88872view 12:46, 16 August 2016AgustinGVPeriodical save, work in progress
88871view 12:44, 16 August 2016AgustinGVNew pathway

External references


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NameTypeDatabase referenceComment
Atp1a1GeneProduct24211 (Entrez Gene)
Atp1b1GeneProduct25650 (Entrez Gene)
Atp1b3GeneProduct25390 (Entrez Gene)
Atp6v0a1 GeneProduct29757 (Entrez Gene)
Atp6v0a2 GeneProduct116455 (Entrez Gene)
Atp6v0a4 GeneProduct296981 (Entrez Gene)
Atp6v0b GeneProduct298451 (Entrez Gene)
Atp6v0c GeneProduct170667 (Entrez Gene)
Atp6v0d1 GeneProduct291969 (Entrez Gene)
Atp6v0d2 GeneProduct297932 (Entrez Gene)
Atp6v0e1 GeneProduct94170 (Entrez Gene)
Atp6v0e2GeneProduct436582 (Entrez Gene)
Atp6v1a GeneProduct685232 (Entrez Gene)
Atp6v1b1 GeneProduct312488 (Entrez Gene)
Atp6v1b2 GeneProduct117596 (Entrez Gene)
Atp6v1c1 GeneProduct299971 (Entrez Gene)
Atp6v1d GeneProduct299159 (Entrez Gene)
Atp6v1e1 GeneProduct297566 (Entrez Gene)
Atp6v1f GeneProduct116664 (Entrez Gene)
Atp6v1g1 GeneProduct298103 (Entrez Gene)
Atp6v1g3 GeneProduct289407 (Entrez Gene)
Atp6v1h GeneProduct297797 (Entrez Gene)
B*AT1GeneProduct664630 (Entrez Gene)
BAT-1GeneProduct116726 (Entrez Gene)
CA IIGeneProduct54231 (Entrez Gene)
CA IVGeneProduct29242 (Entrez Gene)
CA VIIGeneProduct291819 (Entrez Gene)
CA XIIGeneProduct363085 (Entrez Gene)
CA XIVGeneProduct791259 (Entrez Gene)
CA XVGeneProduct288360 (Entrez Gene)
CHIFGeneProduct64190 (Entrez Gene)
E. Glutam. Tr.GeneProduct25550 (Entrez Gene)
Gamma 1GeneProduct29639 (Entrez Gene)
LAT1-4F2hcGeneProduct83509 (Entrez Gene)
LAT3-4F2hcGeneProduct307811 (Entrez Gene)
LAT3-4F2hcGeneProduct84551 (Entrez Gene)
NAS1GeneProduct58980 (Entrez Gene)
NBCGeneProduct84484 (Entrez Gene)
NHE3 RegP1GeneProduct59114 (Entrez Gene)
NHE3 RegP2GeneProduct116501 (Entrez Gene)
NHE3GeneProduct24784 (Entrez Gene)
NHE8GeneProduct311651 (Entrez Gene)
NaDC-1GeneProduct65202 (Entrez Gene)
NaDC-3GeneProduct64846 (Entrez Gene)
NaPi-2aGeneProduct25548 (Entrez Gene)
NaPi-2bGeneProduct84395 (Entrez Gene)
OAT1GeneProduct29509 (Entrez Gene)
OAT3GeneProduct83500 (Entrez Gene)
OCTN2GeneProduct29726 (Entrez Gene)
PAT1GeneProduct301010 (Entrez Gene)
Pit-2GeneProduct29502 (Entrez Gene)
SAT1GeneProduct64076 (Entrez Gene)
SNAT7GeneProduct291840 (Entrez Gene)
TAT1GeneProduct170566 (Entrez Gene)

Annotated Interactions

<cite>No annotated interactions</cite>