Renin - Angiotensin System (Rattus norvegicus)

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Cell membrane Cell nucleus Endoplasmatic Reticulum DNA DNA DNA DNA PAK isoforms IPR3 isoforms JNK isoforms Vasodilation, Inhibation of Cellular Proliferation and Induction of Apoptosis Vasadiconstriction, Cellular Proliferation, Hypersecration of Aldosterone, Myocardial Hypertrophy, fibrosis and Renal damage Cpa3 Ppgb Angiotensin (1-9) Angiotensin (1-7) Angiotensin (1-5) Thop1 Nln Mme Enpep Angiotensin III Anpep Angiotensin IV Mas1 Agtr2 Agtr1a Lnpep Angiotensinogen Angiotensin 1 Renin Angiotensin II Ace CMA1 CTSG Ace2 Ace Mme Ace Ace2 PtgIR AC2/3 cAMP PKA SHC Grb2 SOS Ras Raf1 MEKK1 ERK1 Elk1 FAK TYK Jak2 TYK STAT1 STAT3 GalfaQ/11 PI3K Rac1 PAK MEKK1 MKK4 JNK c-Jun c-Fos Plcb1 IP3 IP3R CA2+ PYK2 p38 ATF2 PIP2 DAG Prkcq Ikbkb NF-KB ROS NO PPtase Ceramide PAK1 PAK2 PAK3 PAK4 PAK6 PAK7 Ikbkg Itpr1 Itpr2 Itpr3 MKK7 Mapk8 Mapk9 Mapk10 Mapk3 Name: Renin - Angiotensin System Organism: Rattus norvegicus


This pathway is based on the KEGG pathway of renin-angiotensin and the Ambion pathway of renin-angiotensin

The different colors used in the pathway stand for:

  • Darkblue: gene product.
  • Green: protein.
  • Red: metabolite.
  • Lightblue: protein which occurs in the human, but we don't know if this protein also occurs in the rat.

Quality Tags

Ontology Terms



  1. Thoidis G, Kandror KV; ''A Glut4-vesicle marker protein, insulin-responsive aminopeptidase, is localized in a novel vesicular compartment in PC12 cells.''; Traffic, 2001 PubMed
  2. Ballard-Croft C, Locklar AC, Keith BJ, Mentzer RM Jr, Lasley RD; ''Oxidative stress and adenosine A1 receptor activation differentially modulate subcellular cardiomyocyte MAPKs.''; Am J Physiol Heart Circ Physiol, 2008 PubMed
  3. Fukamizu A, Nishi K, Cho T, Saitoh M, Nakayama K, Ohkubo H, Nakanishi S, Murakami K; ''Structure of the rat renin gene.''; J Mol Biol, 1988 PubMed
  4. Bjork P, Ohlsson K; ''Purification and N-terminal amino-acid sequence analysis of rat polymorphonuclear leukocyte cathepsin G.''; Biol Chem Hoppe Seyler, 1990 PubMed
  5. Sundberg-Smith LJ, Doherty JT, Mack CP, Taylor JM; ''Adhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylation.''; J Biol Chem, 2005 PubMed
  6. Towler P, Staker B, Prasad SG, Menon S, Tang J, Parsons T, Ryan D, Fisher M, Williams D, Dales NA, Patane MA, Pantoliano MW; ''ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis.''; J Biol Chem, 2004 PubMed
  7. Dennehy KM, Kerstan A, Bischof A, Park JH, Na SY, Hunig T; ''Mitogenic signals through CD28 activate the protein kinase Ctheta-NF-kappaB pathway in primary peripheral T cells.''; Int Immunol, 2003 PubMed
  8. Inagami T, Iwai N, Sasaki K, Yamano Y, Bardhan S, Chaki S, Guo DF, Furuta H, Ohyama K, Kambayashi Y; ''Cloning, expression and regulation of angiotensin II receptors.''; Eur Heart J, 1994 PubMed
  9. Haworth RS, Roberts NA, Cuello F, Avkiran M; ''Regulation of protein kinase D activity in adult myocardium: novel counter-regulatory roles for protein kinase Cepsilon and protein kinase A.''; J Mol Cell Cardiol, 2007 PubMed
  10. Mukoyama M, Nakajima M, Horiuchi M, Sasamura H, Pratt RE, Dzau VJ; ''Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors.''; J Biol Chem, 1993 PubMed
  11. Burnham CE, Hawelu-Johnson CL, Frank BM, Lynch KR; ''Molecular cloning of rat renin cDNA and its gene.''; Proc Natl Acad Sci U S A, 1987 PubMed
  12. Kishi K, Jin D, Takai S, Muramatsu M, Katayama H, Tamai H, Miyazaki M; ''Role of chymase-dependent angiotensin II formation in monocrotaline-induced pulmonary hypertensive rats.''; Pediatr Res, 2006 PubMed
  13. Augustyniak RA, Maliszewska-Scislo M, Chen H, Fallucca J, Rossi NF; ''Acute angiotensin-converting enzyme inhibition evokes bradykinin-induced sympathetic activation in diabetic rats.''; Am J Physiol Regul Integr Comp Physiol, 2007 PubMed
  14. Malfroy B, Schofield PR, Kuang WJ, Seeburg PH, Mason AJ, Henzel WJ; ''Molecular cloning and amino acid sequence of rat enkephalinase.''; Biochem Biophys Res Commun, 1987 PubMed
  15. Reudelhuber TL; ''The renin-angiotensin system: peptides and enzymes beyond angiotensin II.''; Curr Opin Nephrol Hypertens, 2005 PubMed
  16. Liao H, Keller SR, Castle JD; ''Insulin-regulated aminopeptidase marks an antigen-stimulated recycling compartment in mast cells.''; Traffic, 2006 PubMed
  17. Young D, O'Neill K, Jessell T, Wigler M; ''Characterization of the rat mas oncogene and its high-level expression in the hippocampus and cerebral cortex of rat brain.''; Proc Natl Acad Sci U S A, 1988 PubMed
  18. Koike G, Winer ES, Horiuchi M, Brown DM, Szpirer C, Dzau VJ, Jacob HJ; ''Cloning, characterization, and genetic mapping of the rat type 2 angiotensin II receptor gene.''; Hypertension, 1995 PubMed
  19. Kim JS, Jobin C; ''The flavonoid luteolin prevents lipopolysaccharide-induced NF-kappaB signalling and gene expression by blocking IkappaB kinase activity in intestinal epithelial cells and bone-marrow derived dendritic cells.''; Immunology, 2005 PubMed
  20. Trask AJ, Averill DB, Ganten D, Chappell MC, Ferrario CM; ''Primary role of angiotensin-converting enzyme-2 in cardiac production of angiotensin-(1-7) in transgenic Ren-2 hypertensive rats.''; Am J Physiol Heart Circ Physiol, 2007 PubMed
  21. Dauch P, Vincent JP, Checler F; ''Molecular cloning and expression of rat brain endopeptidase''; J Biol Chem, 1995 PubMed
  22. Deng AY, Rapp JP; ''Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat.''; J Clin Invest, 1995 PubMed
  23. Zhou J, Hu G, Herring BP; ''Smooth muscle-specific genes are differentially sensitive to inhibition by Elk-1.''; Mol Cell Biol, 2005 PubMed
  24. Kim SO, Irwin P, Katz S, Pelech SL; ''Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart.''; J Cell Biochem, 1998 PubMed
  25. Padia SH, Kemp BA, Howell NL, Fournie-Zaluski MC, Roques BP, Carey RM; ''Conversion of renal angiotensin II to angiotensin III is critical for AT2 receptor-mediated natriuresis in rats.''; Hypertension, 2008 PubMed
  26. Tada M, Fukamizu A, Seo MS, Takahashi S, Murakami K; ''Nucleotide sequence of rat renin cDNA.''; Nucleic Acids Res, 1988 PubMed
  27. Kokkinos MI, Brown HJ, de Iongh RU; ''Focal adhesion kinase (FAK) expression and activation during lens development.''; Mol Vis, 2007 PubMed
  28. Tronik D, Ekker M, Rougeon F; ''Structural analysis of 5'-flanking regions of rat, mouse and human renin genes reveals the presence of a transposable-like element in the two mouse genes.''; Gene, 1988 PubMed
  29. Rivera P, Ocaranza MP, Lavandero S, Jalil JE; ''Rho kinase activation and gene expression related to vascular remodeling in normotensive rats with high angiotensin I converting enzyme levels.''; Hypertension, 2007 PubMed
  30. Bouallegue A, Daou GB, Srivastava AK; ''Nitric oxide attenuates endothelin-1-induced activation of ERK1/2, PKB, and Pyk2 in vascular smooth muscle cells by a cGMP-dependent pathway.''; Am J Physiol Heart Circ Physiol, 2007 PubMed
  31. Sadjadi J, Kramer GL, Yu CH, Burress Welborn M 3rd, Chappell MC, Gregory Modrall J; ''Angiotensin converting enzyme-independent angiotensin ii production by chymase is up-regulated in the ischemic kidney in renovascular hypertension.''; J Surg Res, 2005 PubMed
  32. Nakayama T, Nakajima T, Sokabe H; ''Comparative studies on angiotensins. II. Structure of rat angiotensin and its identification by DNS-method.''; Chem Pharm Bull (Tokyo), 1972 PubMed
  33. Jacob HJ, Lindpaintner K, Lincoln SE, Kusumi K, Bunker RK, Mao YP, Ganten D, Dzau VJ, Lander ES; ''Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat.''; Cell, 1991 PubMed
  34. Heikkila HM, Lutti S, Leskinen MJ, Hakala JK, Kovanen PT, Lindstedt KA; ''Activated mast cells induce endothelial cell apoptosis by a combined action of chymase and tumor necrosis factor-alpha.''; Arterioscler Thromb Vasc Biol, 2008 PubMed
  35. Uematsu F, Takahashi M, Yoshida M, Igarashi M, Nakae D; ''Methylation of neutral endopeptidase 24.11 promoter in rat hepatocellular carcinoma.''; Cancer Sci, 2006 PubMed
  36. Waetzig V, Herdegen T; ''MEKK1 controls neurite regrowth after experimental injury by balancing ERK1/2 and JNK2 signaling.''; Mol Cell Neurosci, 2005 PubMed
  37. Troyanovskaya M, Song L, Jayaraman G, Healy DP; ''Expression of aminopeptidase A, an angiotensinase, in glomerular mesangial cells.''; Hypertension, 1996 PubMed
  38. Langford K, Frenzel K, Martin BM, Bernstein KE; ''The genomic organization of the rat AT1 angiotensin receptor.''; Biochem Biophys Res Commun, 1992 PubMed
  39. Watt VM, Yip CC; ''Amino acid sequence deduced from a rat kidney cDNA suggests it encodes the Zn-peptidase aminopeptidase N.''; J Biol Chem, 1989 PubMed
  40. Saito N, Courtois G, Chiba A, Yamamoto N, Nitta T, Hironaka N, Rowe M, Yamaoka S; ''Two carboxyl-terminal activation regions of Epstein-Barr virus latent membrane protein 1 activate NF-kappaB through distinct signaling pathways in fibroblast cell lines.''; J Biol Chem, 2003 PubMed
  41. Rafiq K, Hanscom M, Valerie K, Steinberg SF, Sabri A; ''Novel mode for neutrophil protease cathepsin G-mediated signaling: membrane shedding of epidermal growth factor is required for cardiomyocyte anoikis.''; Circ Res, 2008 PubMed
  42. Mecawi Ade S, Lepletier A, de Araujo IG, Olivares EL, Reis LC; ''Assessment of brain AT1-receptor on the nocturnal basal and angiotensin-induced thirst and sodium appetite in ovariectomised rats.''; J Renin Angiotensin Aldosterone Syst, 2007 PubMed
  43. Houdali B, Nguyen V, Ammon HP, Haap M, Schechinger W, Machicao F, Rett K, Haring HU, Schleicher ED; ''Prolonged glucose infusion into conscious rats inhibits early steps in insulin signalling and induces translocation of GLUT4 and protein kinase C in skeletal muscle.''; Diabetologia, 2002 PubMed
  44. Zhang Y, Zhang H, Yuan X, Gu X; ''Differential effects of phenylalanine on Rac1, Cdc42, and RhoA expression and activity in cultured cortical neurons.''; Pediatr Res, 2007 PubMed
  45. Ide H, Itoh H, Tomita M, Murakumo Y, Kobayashi T, Maruyama H, Osada Y, Nawa Y; ''Cloning of the cDNA encoding a novel rat mast-cell proteinase, rMCP-3, and its expression in comparison with other rat mast-cell proteinases.''; Biochem J, 1995 PubMed
  46. Kotlo K, Hughes DE, Herrera VL, Ruiz-Opazo N, Costa RH, Robey RB, Danziger RS; ''Functional polymorphism of the Anpep gene increases promoter activity in the Dahl salt-resistant rat.''; Hypertension, 2007 PubMed
  47. Oya M, Mikami S, Mizuno R, Marumo K, Mukai M, Murai M; ''C-jun activation in acquired cystic kidney disease and renal cell carcinoma.''; J Urol, 2005 PubMed
  48. Inukai T, Osuka K, Takagi T, Usuda N, Yoshida J, Takayasu M; ''Activation of c-jun in the rat basilar artery after subarachnoid hemorrhage.''; Neurosci Lett, 2007 PubMed
  49. Fu YC, Yin SC, Chi CS, Hwang B, Hsu SL; ''Norepinephrine induces apoptosis in neonatal rat endothelial cells via a ROS-dependent JNK activation pathway.''; Apoptosis, 2006 PubMed
  50. Lutzelschwab C, Pejler G, Aveskogh M, Hellman L; ''Secretory granule proteases in rat mast cells. Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations.''; J Exp Med, 1997 PubMed
  51. Vlahovic P, Cvetkovic T, Nikolic J, Sokolovic D; ''Ethanol inhibitory effect on rat kidney brush border aminopeptidases.''; Nephron Exp Nephrol, 2007 PubMed
  52. Der Sarkissian S, Grobe JL, Yuan L, Narielwala DR, Walter GA, Katovich MJ, Raizada MK; ''Cardiac overexpression of angiotensin converting enzyme 2 protects the heart from ischemia-induced pathophysiology.''; Hypertension, 2008 PubMed
  53. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA; ''Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.''; Proc Natl Acad Sci U S A, 2002 PubMed
  54. Lee HJ, Tomioka M, Takaki Y, Masumoto H, Saido TC; ''Molecular cloning and expression of aminopeptidase A isoforms from rat hippocampus.''; Biochim Biophys Acta, 2000 PubMed
  55. Martinelli I, Mainini E, Mazzi C; ''Effect of 5-hydroxytryptophan on the secretion of PRL, GH, TSH and cortisol in obesity''; Minerva Endocrinol, 1992 PubMed
  56. Oliveira V, Garrido PA, Rodrigues CC, Colquhoun A, Castro LM, Almeida PC, Shida CS, Juliano MA, Juliano L, Camargo AC, Hyslop S, Roberts JL, Grum-Tokars V, Glucksman MJ, Ferro ES; ''Calcium modulates endopeptidase 24.15 (EC membrane association, secondary structure and substrate specificity.''; FEBS J, 2005 PubMed
  57. Jackson EK, Gillespie DG, Zhu C, Ren J, Zacharia LC, Mi Z; ''Alpha2-adrenoceptors enhance angiotensin II-induced renal vasoconstriction: role for NADPH oxidase and RhoA.''; Hypertension, 2008 PubMed
  58. Herath CB, Warner FJ, Lubel JS, Dean RG, Jia Z, Lew RA, Smith AI, Burrell LM, Angus PW; ''Upregulation of hepatic angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1-7) levels in experimental biliary fibrosis.''; J Hepatol, 2007 PubMed
  59. Reudelhuber TL; ''A place in our hearts for the lowly angiotensin 1-7 peptide?''; Hypertension, 2006 PubMed
  60. Leckie BJ; ''Targeting the renin-angiotensin system: what's new?''; Curr Med Chem Cardiovasc Hematol Agents, 2005 PubMed
  61. Kyriakis JM, Banerjee P, Nikolakaki E, Dai T, Rubie EA, Ahmad MF, Avruch J, Woodgett JR; ''The stress-activated protein kinase subfamily of c-Jun kinases.''; Nature, 1994 PubMed
  62. Bertazolli-Filho R, Coca-Prados M, Haddad A, Laicine EM; ''Molecular analysis of neurolysin expression in the rat and bovine ciliary body.''; Curr Eye Res, 2007 PubMed
  63. Ahmed MM, Arif M, Chikuma T, Kato T; ''Pentylenetetrazol-induced seizures affect the levels of prolyl oligopeptidase, thimet oligopeptidase and glial proteins in rat brain regions, and attenuation by MK-801 pretreatment.''; Neurochem Int, 2005 PubMed
  64. Carini R, Alchera E, Baldanzi G, Piranda D, Splendore R, Grazia De Cesaris M, Caraceni P, Graziani A, Albano E; ''Role of p38 map kinase in glycine-induced hepatocyte resistance to hypoxic injury.''; J Hepatol, 2007 PubMed
  65. Mustonen H, Hietaranta A, Puolakkainen P, Kemppainen E, Paimela H, Kiviluoto T, Kivilaakso E; ''Ethanol induced NF-{kappa}B activation protects against cell injury in cultured rat gastric mucosal epithelium.''; Am J Physiol Gastrointest Liver Physiol, 2007 PubMed
  66. Leskinen MJ, Lindstedt KA, Wang Y, Kovanen PT; ''Mast cell chymase induces smooth muscle cell apoptosis by a mechanism involving fibronectin degradation and disruption of focal adhesions.''; Arterioscler Thromb Vasc Biol, 2003 PubMed
  67. Li CH, Wang RM, Zhang QG, Zhang GY; ''Activated mitogen-activated protein kinase kinase 7 redistributes to the cytosol and binds to Jun N-terminal kinase-interacting protein 1 involving oxidative stress during early reperfusion in rat hippocampal CA1 region.''; J Neurochem, 2005 PubMed
  68. McKie N, Dando PM, Rawlings ND, Barrett AJ; ''Thimet oligopeptidase: similarity to 'soluble angiotensin II-binding protein' and some corrections to the published amino acid sequence of the rat testis enzyme.''; Biochem J, 1993 PubMed
  69. Ray K, Hines CS, Rodgers DW; ''Mapping sequence differences between thimet oligopeptidase and neurolysin implicates key residues in substrate recognition.''; Protein Sci, 2002 PubMed
  70. Zhang J, Anastasiadis PZ, Liu Y, Thompson EA, Fields AP; ''Protein kinase C (PKC) betaII induces cell invasion through a Ras/Mek-, PKC iota/Rac 1-dependent signaling pathway.''; J Biol Chem, 2004 PubMed
  71. Brosnihan KB, Neves LA, Joyner J, Averill DB, Chappell MC, Sarao R, Penninger J, Ferrario CM; ''Enhanced renal immunocytochemical expression of ANG-(1-7) and ACE2 during pregnancy.''; Hypertension, 2003 PubMed
  72. Clement N, Glorian M, Raymondjean M, Andreani M, Limon I; ''PGE2 amplifies the effects of IL-1beta on vascular smooth muscle cell de-differentiation: a consequence of the versatility of PGE2 receptors 3 due to the emerging expression of adenylyl cyclase 8.''; J Cell Physiol, 2006 PubMed
  73. Chappell MC, Gomez MN, Pirro NT, Ferrario CM; ''Release of angiotensin-(1-7) from the rat hindlimb: influence of angiotensin-converting enzyme inhibition.''; Hypertension, 2000 PubMed
  74. Funkhouser JD, Tangada SD, Jones M, O SJ, Peterson RD; ''p146 type II alveolar epithelial cell antigen is identical to aminopeptidase N.''; Am J Physiol, 1991 PubMed
  75. Norman MU, Lew RA, Smith AI, Hickey MJ; ''Metalloendopeptidases EC regulate bradykinin activity in the cerebral microvasculature.''; Am J Physiol Heart Circ Physiol, 2003 PubMed
  76. Aiello S, Cassis P, Cassis L, Tomasoni S, Benigni A, Pezzotta A, Cavinato RA, Cugini D, Azzollini N, Mister M, Longaretti L, Thomson AW, Remuzzi G, Noris M; ''DnIKK2-transfected dendritic cells induce a novel population of inducible nitric oxide synthase-expressing CD4+CD25- cells with tolerogenic properties.''; Transplantation, 2007 PubMed
  77. Serizawa A, Dando PM, Barrett AJ; ''Characterization of a mitochondrial metallopeptidase reveals neurolysin as a homologue of thimet oligopeptidase.''; J Biol Chem, 1995 PubMed
  78. Fontan E, Traincard F, Levy SG, Yamaoka S, Veron M, Agou F; ''NEMO oligomerization in the dynamic assembly of the IkappaB kinase core complex.''; FEBS J, 2007 PubMed
  79. Stragier B, Demaegdt H, De Bundel D, Smolders I, Sarre S, Vauquelin G, Ebinger G, Michotte Y, Vanderheyden P; ''Involvement of insulin-regulated aminopeptidase and/or aminopeptidase N in the angiotensin IV-induced effect on dopamine release in the striatum of the rat.''; Brain Res, 2007 PubMed
  80. Sleat DE, Sohar I, Lackland H, Majercak J, Lobel P; ''Rat brain contains high levels of mannose-6-phosphorylated glycoproteins including lysosomal enzymes and palmitoyl-protein thioesterase, an enzyme implicated in infantile neuronal lipofuscinosis.''; J Biol Chem, 1996 PubMed
  81. Zhang Y, Vogel WK, McCullar JS, Greenwood JA, Filtz TM; ''Phospholipase C-beta3 and -beta1 form homodimers, but not heterodimers, through catalytic and carboxyl-terminal domains.''; Mol Pharmacol, 2006 PubMed
  82. Gillis LD, Pendley DS, Funkhouser JD; ''The major APN transcript of the alveolar type II epithelial cell originates from a unique upstream promoter region.''; Biochim Biophys Acta, 1998 PubMed
  83. Ronchi FA, Irigoyen MC, Casarini DE; ''Association of somatic and N-domain angiotensin-converting enzymes from Wistar rat tissue with renal dysfunction in diabetes mellitus.''; J Renin Angiotensin Aldosterone Syst, 2007 PubMed
  84. Brown CK, Madauss K, Lian W, Beck MR, Tolbert WD, Rodgers DW; ''Structure of neurolysin reveals a deep channel that limits substrate access.''; Proc Natl Acad Sci U S A, 2001 PubMed
  85. Rogel A, Bromberg Y, Sperling O, Zoref-Shani E; ''The neuroprotective adenosine-activated signal transduction pathway involves activation of phospholipase C.''; Nucleosides Nucleotides Nucleic Acids, 2006 PubMed
  86. Pilar Carrera M, Ramirez-Exposito MJ, Duenas B, Dolores Mayas M, Jesus Garcia M, De la Chica S, Cortes P, Ruiz-Sanjuan M, Martinez-Martos JM; ''Insulin-regulated aminopeptidase/placental leucil Aminopeptidase (IRAP/P-lAP) and angiotensin IV-forming activities are modified in serum of rats with breast cancer induced by N-methyl-nitrosourea.''; Anticancer Res, 2006 PubMed
  87. van den Brink OW, Delbridge LM, Pedrazzini T, Rosenfeldt FL, Pepe S; ''Augmented myocardial methionine-enkephalin in a murine model of cardiac angiotensin II-overexpression.''; J Renin Angiotensin Aldosterone Syst, 2007 PubMed
  88. Herschkovitz A, Liu YF, Ilan E, Ronen D, Boura-Halfon S, Zick Y; ''Common inhibitory serine sites phosphorylated by IRS-1 kinases, triggered by insulin and inducers of insulin resistance.''; J Biol Chem, 2007 PubMed
  89. Hu MC, Wang YP, Mikhail A, Qiu WR, Tan TH; ''Murine p38-delta mitogen-activated protein kinase, a developmentally regulated protein kinase that is activated by stress and proinflammatory cytokines.''; J Biol Chem, 1999 PubMed
  90. Chaturvedi LS, Marsh HM, Shang X, Zheng Y, Basson MD; ''Repetitive deformation activates focal adhesion kinase and ERK mitogenic signals in human Caco-2 intestinal epithelial cells through Src and Rac1.''; J Biol Chem, 2007 PubMed
  91. Kramar EA, Armstrong DL, Ikeda S, Wayner MJ, Harding JW, Wright JW; ''The effects of angiotensin IV analogs on long-term potentiation within the CA1 region of the hippocampus in vitro.''; Brain Res, 2001 PubMed
  92. Huffman LC, Koch SE, Butler KL; ''Coronary effluent from a preconditioned heart activates the JAK-STAT pathway and induces cardioprotection in a donor heart.''; Am J Physiol Heart Circ Physiol, 2008 PubMed
  93. Seyfried J, Wullner U; ''Inhibition of thioredoxin reductase induces apoptosis in neuronal cell lines: role of glutathione and the MKK4/JNK pathway.''; Biochem Biophys Res Commun, 2007 PubMed
  94. Fraga-Silva RA, Pinheiro SV, Goncalves AC, Alenina N, Bader M, Santos RA; ''The antithrombotic effect of angiotensin-(1-7) involves mas-mediated NO release from platelets.''; Mol Med, 2008 PubMed
  95. Cali JJ, Zwaagstra JC, Mons N, Cooper DM, Krupinski J; ''Type VIII adenylyl cyclase. A Ca2+/calmodulin-stimulated enzyme expressed in discrete regions of rat brain.''; J Biol Chem, 1994 PubMed
  96. Tikellis C, Johnston CI, Forbes JM, Burns WC, Burrell LM, Risvanis J, Cooper ME; ''Characterization of renal angiotensin-converting enzyme 2 in diabetic nephropathy.''; Hypertension, 2003 PubMed
  97. Olson ER, Shamhart PE, Naugle JE, Meszaros JG; ''Angiotensin II-induced extracellular signal-regulated kinase 1/2 activation is mediated by protein kinase Cdelta and intracellular calcium in adult rat cardiac fibroblasts.''; Hypertension, 2008 PubMed
  98. Cieslak D, Lazou A; ''Regulation of BAD protein by PKA, PKCdelta and phosphatases in adult rat cardiac myocytes subjected to oxidative stress.''; Mol Cells, 2007 PubMed
  99. Jiang Q, Gu Z, Zhang G; ''Activation, involvement and nuclear translocation of c-Jun N-terminal protein kinase 1 and 2 in glutamate-induced apoptosis in cultured rat cortical neurons.''; Brain Res, 2002 PubMed
  100. Ye MQ, Healy DP; ''Characterization of an angiotensin type-1 receptor partial cDNA from rat kidney: evidence for a novel AT1B receptor subtype.''; Biochem Biophys Res Commun, 1992 PubMed
  101. Polk WW, Ellis ME, Kushleika JV, Simmonds PL, Woods JS; ''RhoA regulation of NF-kappaB activation is mediated by COX-2-dependent feedback inhibition of IKK in kidney epithelial cells.''; Am J Physiol Cell Physiol, 2007 PubMed
  102. Kwitek AE, Gullings-Handley J, Yu J, Carlos DC, Orlebeke K, Nie J, Eckert J, Lemke A, Andrae JW, Bromberg S, Pasko D, Chen D, Scheetz TE, Casavant TL, Soares MB, Sheffield VC, Tonellato PJ, Jacob HJ; ''High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.''; Genome Res, 2004 PubMed
  103. Wang SF, Liang Q, Li GW, Gao K; ''Gene expression profile in rat small intestinal allografts after cold preservation/reperfusion.''; World J Gastroenterol, 2005 PubMed
  104. Cerezo-Guisado MI, Alvarez-Barrientos A, Argent R, Garcia-Marin LJ, Bragado MJ, Lorenzo MJ; ''c-Jun N-terminal protein kinase signalling pathway mediates lovastatin-induced rat brain neuroblast apoptosis.''; Biochim Biophys Acta, 2007 PubMed
  105. Tsai CT, Lai LP, Kuo KT, Hwang JJ, Hsieh CS, Hsu KL, Tseng CD, Tseng YZ, Chiang FT, Lin JL; ''Angiotensin II activates signal transducer and activators of transcription 3 via Rac1 in atrial myocytes and fibroblasts: implication for the therapeutic effect of statin in atrial structural remodeling.''; Circulation, 2008 PubMed
  106. Iwai N, Inagami T; ''Identification of two subtypes in the rat type I angiotensin II receptor.''; FEBS Lett, 1992 PubMed
  107. Schmid C, Ghirlanda-Keller C, Gosteli-Peter M; ''Ascorbic acid decreases neutral endopeptidase activity in cultured osteoblastic cells.''; Regul Pept, 2005 PubMed
  108. Malfroy B, Kado-Fong H, Gros C, Giros B, Schwartz JC, Hellmiss R; ''Molecular cloning and amino acid sequence of rat kidney aminopeptidase M: a member of a super family of zinc-metallohydrolases.''; Biochem Biophys Res Commun, 1989 PubMed
  109. Cole KR, Kumar S, Trong HL, Woodbury RG, Walsh KA, Neurath H; ''Rat mast cell carboxypeptidase: amino acid sequence and evidence of enzyme activity within mast cell granules.''; Biochemistry, 1991 PubMed
  110. Li W, Moore MJ, Vasilieva N, Sui J, Wong SK, Berne MA, Somasundaran M, Sullivan JL, Luzuriaga K, Greenough TC, Choe H, Farzan M; ''Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus.''; Nature, 2003 PubMed
  111. Hobara N, Goda M, Yoshida N, Takatori S, Kitamura Y, Mio M, Kawasaki H; ''Angiotensin II type 2 receptors facilitate reinnervation of phenol-lesioned vascular calcitonin gene-related peptide-containing nerves in rat mesenteric arteries.''; Neuroscience, 2007 PubMed
  112. Shi ST, Li YF; ''Interaction of signal transduction between angiotensin AT1 and AT2 receptor subtypes in rat senescent heart.''; Chin Med J (Engl), 2007 PubMed
  113. Zylka MJ, Dong X, Southwell AL, Anderson DJ; ''Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family.''; Proc Natl Acad Sci U S A, 2003 PubMed
  114. Bateman RC Jr, Jackson D, Slaughter CA, Unnithan S, Chai YG, Moomaw C, Hersh LB; ''Identification of the active-site arginine in rat neutral endopeptidase 24.11 (enkephalinase) as arginine 102 and analysis of a glutamine 102 mutant.''; J Biol Chem, 1989 PubMed
  115. Pierotti A, Dong KW, Glucksman MJ, Orlowski M, Roberts JL; ''Molecular cloning and primary structure of rat testes metalloendopeptidase EC''; Biochemistry, 1990 PubMed
  116. Ohkubo H, Nakayama K, Tanaka T, Nakanishi S; ''Tissue distribution of rat angiotensinogen mRNA and structural analysis of its heterogeneity.''; J Biol Chem, 1986 PubMed
  117. Paliege A, Pasumarthy A, Mizel D, Yang T, Schnermann J, Bachmann S; ''Effect of apocynin treatment on renal expression of COX-2, NOS1, and renin in Wistar-Kyoto and spontaneously hypertensive rats.''; Am J Physiol Regul Integr Comp Physiol, 2006 PubMed
  118. Wang YX, Ding YJ, Zhu YZ, Shi Y, Yao T, Zhu YC; ''Role of PKC in the novel synergistic action of urotensin II and angiotensin II and in urotensin II-induced vasoconstriction.''; Am J Physiol Heart Circ Physiol, 2007 PubMed
  119. Deng AY, Dene H, Rapp JP; ''Mapping of a quantitative trait locus for blood pressure on rat chromosome 2.''; J Clin Invest, 1994 PubMed
  120. Laes JF, Ravoet M, Quan X, Van Vooren P, Szpirer J, Szpirer C; ''Improved radiation hybrid map of rat chromosome 2: colocalization of the genes encoding corticotropin-releasing hormone and IL6-receptor with quantitative trait loci regulating the inflammatory response.''; Cytogenet Cell Genet, 2001 PubMed
  121. Leskinen MJ, Heikkila HM, Speer MY, Hakala JK, Laine M, Kovanen PT, Lindstedt KA; ''Mast cell chymase induces smooth muscle cell apoptosis by disrupting NF-kappaB-mediated survival signaling.''; Exp Cell Res, 2006 PubMed
  122. Mastick CC, Aebersold R, Lienhard GE; ''Characterization of a major protein in GLUT4 vesicles. Concentration in the vesicles and insulin-stimulated translocation to the plasma membrane.''; J Biol Chem, 1994 PubMed
  123. Rider L, Shatrova A, Feener EP, Webb L, Diakonova M; ''JAK2 tyrosine kinase phosphorylates PAK1 and regulates PAK1 activity and functions.''; J Biol Chem, 2007 PubMed
  124. Khurana A, Dey CS; ''Involvement of Elk-1 in L6E9 skeletal muscle differentiation.''; FEBS Lett, 2002 PubMed
  125. Levrand S, Pesse B, Feihl F, Waeber B, Pacher P, Rolli J, Schaller MD, Liaudet L; ''Peroxynitrite is a potent inhibitor of NF-{kappa}B activation triggered by inflammatory stimuli in cardiac and endothelial cell lines.''; J Biol Chem, 2005 PubMed
  126. Hodges RR, Rios JD, Vrouvlianis J, Ota I, Zoukhri D, Dartt DA; ''Roles of protein kinase C, Ca2+, Pyk2, and c-Src in agonist activation of rat lacrimal gland p42/p44 MAPK.''; Invest Ophthalmol Vis Sci, 2006 PubMed
  127. Veerappan A, Reid AC, Estephan R, O'Connor N, Thadani-Mulero M, Salazar-Rodriguez M, Levi R, Silver RB; ''Mast cell renin and a local renin-angiotensin system in the airway: role in bronchoconstriction.''; Proc Natl Acad Sci U S A, 2008 PubMed
  128. Kobayashi S, Ohnishi J, Nibu Y, Nishimatsu S, Umemura S, Ishii M, Murakami K, Miyazaki H; ''Cloning of the rat angiotensin II type 2 receptor gene and identification of its functional promoter region.''; Biochim Biophys Acta, 1995 PubMed
  129. Ocaranza MP, Godoy I, Jalil JE, Varas M, Collantes P, Pinto M, Roman M, Ramirez C, Copaja M, Diaz-Araya G, Castro P, Lavandero S; ''Enalapril attenuates downregulation of Angiotensin-converting enzyme 2 in the late phase of ventricular dysfunction in myocardial infarcted rat.''; Hypertension, 2006 PubMed
  130. Karlson U, Pejler G, Tomasini-Johansson B, Hellman L; ''Extended substrate specificity of rat mast cell protease 5, a rodent alpha-chymase with elastase-like primary specificity.''; J Biol Chem, 2003 PubMed
  131. Palm F, Connors SG, Mendonca M, Welch WJ, Wilcox CS; ''Angiotensin II type 2 receptors and nitric oxide sustain oxygenation in the clipped kidney of early Goldblatt hypertensive rats.''; Hypertension, 2008 PubMed
  132. Deng Y, Rapp JP; ''Cosegregation of blood pressure with angiotensin converting enzyme and atrial natriuretic peptide receptor genes using Dahl salt-sensitive rats.''; Nat Genet, 1992 PubMed
  133. Nguyen G; ''Renin/prorenin receptors.''; Kidney Int, 2006 PubMed
  134. Norman MU, Reeve SB, Dive V, Smith AI, Lew RA; ''Endopeptidases and 24.16 in endothelial cells: potential role in vasoactive peptide metabolism.''; Am J Physiol Heart Circ Physiol, 2003 PubMed
  135. Guo Z, Jiang H, Xu X, Duan W, Mattson MP; ''Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization.''; J Biol Chem, 2008 PubMed
  136. Harris EL, Phelan EL, Thompson CM, Millar JA, Grigor MR; ''Heart mass and blood pressure have separate genetic determinants in the New Zealand genetically hypertensive (GH) rat.''; J Hypertens, 1995 PubMed
  137. Tallant EA, Ferrario CM, Gallagher PE; ''Angiotensin-(1-7) inhibits growth of cardiac myocytes through activation of the mas receptor.''; Am J Physiol Heart Circ Physiol, 2005 PubMed
  138. Butterfield L, Zentrich E, Beekman A, Heasley LE; ''Stress- and cell type-dependent regulation of transfected c-Jun N-terminal kinase and mitogen-activated protein kinase kinase isoforms.''; Biochem J, 1999 PubMed
  139. Rafiq K, Kolpakov MA, Abdelfettah M, Streblow DN, Hassid A, Dell'Italia LJ, Sabri A; ''Role of protein-tyrosine phosphatase SHP2 in focal adhesion kinase down-regulation during neutrophil cathepsin G-induced cardiomyocytes anoikis.''; J Biol Chem, 2006 PubMed
  140. Banes-Berceli AK, Ketsawatsomkron P, Ogbi S, Patel B, Pollock DM, Marrero MB; ''Angiotensin II and endothelin-1 augment the vascular complications of diabetes via JAK2 activation.''; Am J Physiol Heart Circ Physiol, 2007 PubMed
  141. Carrera MP, Ramirez-Exposito MJ, Valenzuela MT, Duenas B, Garcia MJ, Mayas MD, Martinez-Martos JM; ''Renin-angiotensin system-regulating aminopeptidase activities are modified in the pineal gland of rats with breast cancer induced by N-methyl-nitrosourea.''; Cancer Invest, 2006 PubMed
  142. Sanchez-Lopez E, Rodriguez-Vita J, Cartier C, Ruperez M, Esteban V, Carvajal G, Rodrigues-Diez R, Plaza JJ, Egido J, Ruiz-Ortega M; ''Inhibitory effect of interleukin-1beta on angiotensin II-induced connective tissue growth factor and type IV collagen production in cultured mesangial cells.''; Am J Physiol Renal Physiol, 2008 PubMed
  143. Morrison LS, Pierotti AR; ''Thimet oligopeptidase expression is differentially regulated in neuroendocrine and spermatid cell lines by transcription factor binding to SRY (sex-determining region Y), CAAT and CREB (cAMP-response-element-binding protein) promoter consensus sequences.''; Biochem J, 2003 PubMed
  144. Neves LA, Stovall K, Joyner J, Valdes G, Gallagher PE, Ferrario CM, Merrill DC, Brosnihan KB; ''ACE2 and ANG-(1-7) in the rat uterus during early and late gestation.''; Am J Physiol Regul Integr Comp Physiol, 2008 PubMed
  145. Keller SR, Scott HM, Mastick CC, Aebersold R, Lienhard GE; ''Cloning and characterization of a novel insulin-regulated membrane aminopeptidase from Glut4 vesicles.''; J Biol Chem, 1995 PubMed
  146. Russo A, Russo G, Peticca M, Pietropaolo C, Di Rosa M, Iuvone T; ''Inhibition of granuloma-associated angiogenesis by controlling mast cell mediator release: role of mast cell protease-5.''; Br J Pharmacol, 2005 PubMed
  147. Whaley-Connell A, Govindarajan G, Habibi J, Hayden MR, Cooper SA, Wei Y, Ma L, Qazi M, Link D, Karuparthi PR, Stump C, Ferrario C, Sowers JR; ''Angiotensin II-mediated oxidative stress promotes myocardial tissue remodeling in the transgenic (mRen2) 27 Ren2 rat.''; Am J Physiol Endocrinol Metab, 2007 PubMed
  148. Crackower MA, Sarao R, Oudit GY, Yagil C, Kozieradzki I, Scanga SE, Oliveira-dos-Santos AJ, da Costa J, Zhang L, Pei Y, Scholey J, Ferrario CM, Manoukian AS, Chappell MC, Backx PH, Yagil Y, Penninger JM; ''Angiotensin-converting enzyme 2 is an essential regulator of heart function.''; Nature, 2002 PubMed
  149. Manser E, Leung T, Salihuddin H, Zhao ZS, Lim L; ''A brain serine/threonine protein kinase activated by Cdc42 and Rac1.''; Nature, 1994 PubMed
  150. Fernando RN, Larm J, Albiston AL, Chai SY; ''Distribution and cellular localization of insulin-regulated aminopeptidase in the rat central nervous system.''; J Comp Neurol, 2005 PubMed
  151. Kreutz R, Huebner N, Ganten D, Lindpaintner K; ''Genetic linkage of the ACE gene to plasma angiotensin-converting enzyme activity but not to blood pressure. A quantitative trait locus confers identical complex phenotypes in human and rat hypertension.''; Circulation, 1995 PubMed
  152. McCool S, Pierotti AR; ''Expression of the thimet oligopeptidase gene is regulated by positively and negatively acting elements.''; DNA Cell Biol, 2000 PubMed
  153. Song L, Ye M, Troyanovskaya M, Wilk E, Wilk S, Healy DP; ''Rat kidney glutamyl aminopeptidase (aminopeptidase A): molecular identity and cellular localization.''; Am J Physiol, 1994 PubMed
  154. Rettig R, Healy DP, Printz MP; ''Cardiovascular effects of microinjections of angiotensin II into the nucleus tractus solitarii.''; Brain Res, 1986 PubMed
  155. Murphy TJ, Alexander RW, Griendling KK, Runge MS, Bernstein KE; ''Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor.''; Nature, 1991 PubMed
  156. Li C, Wang X, Vais H, Thompson CB, Foskett JK, White C; ''Apoptosis regulation by Bcl-x(L) modulation of mammalian inositol 1,4,5-trisphosphate receptor channel isoform gating.''; Proc Natl Acad Sci U S A, 2007 PubMed
  157. Bao JX, Zhang LF, Ma J; ''Angiotensinogen and AT1R expression in cerebral and femoral arteries during hindlimb unloading in rats.''; Aviat Space Environ Med, 2007 PubMed
  158. Healy DP, Printz MP; ''Angiotensinogen levels in the brain and cerebrospinal fluid of the genetically hypertensive rat.''; Hypertension, 1985 PubMed
  159. de Gortari P, Vargas MA, Martinez A, Garcia-Vazquez AI, Uribe RM, Chavez-Gutierrez L, Magdaleno V, Boileau G, Charli JL, Joseph-Bravo P; ''Stage-specific modulation of neprilysin and aminopeptidase N in the limbic system during kindling progression.''; J Mol Neurosci, 2007 PubMed
  160. Takeda Y, Zhu A, Yoneda T, Usukura M, Takata H, Yamagishi M; ''Effects of aldosterone and angiotensin II receptor blockade on cardiac angiotensinogen and angiotensin-converting enzyme 2 expression in Dahl salt-sensitive hypertensive rats.''; Am J Hypertens, 2007 PubMed
  161. Abdelmohsen K, Sauerbier E, Ale-Agha N, Beier J, Walter P, Galban S, Stuhlmann D, Sies H, Klotz LO; ''Epidermal growth factor- and stress-induced loss of gap junctional communication is mediated by ERK-1/ERK-2 but not ERK-5 in rat liver epithelial cells.''; Biochem Biophys Res Commun, 2007 PubMed
  162. Ansar S, Vikman P, Nielsen M, Edvinsson L; ''Cerebrovascular ETB, 5-HT1B, and AT1 receptor upregulation correlates with reduction in regional CBF after subarachnoid hemorrhage.''; Am J Physiol Heart Circ Physiol, 2007 PubMed
  163. Iwai N, Yamano Y, Chaki S, Konishi F, Bardhan S, Tibbetts C, Sasaki K, Hasegawa M, Matsuda Y, Inagami T; ''Rat angiotensin II receptor: cDNA sequence and regulation of the gene expression.''; Biochem Biophys Res Commun, 1991 PubMed
  164. Stempelj M, Kedinger M, Augenlicht L, Klampfer L; ''Essential role of the JAK/STAT1 signaling pathway in the expression of inducible nitric-oxide synthase in intestinal epithelial cells and its regulation by butyrate.''; J Biol Chem, 2007 PubMed
  165. Gao L, Wang W, Li H, Sumners C, Zucker IH; ''Effects of angiotensin type 2 receptor overexpression in the rostral ventrolateral medulla on blood pressure and urine excretion in normal rats.''; Hypertension, 2008 PubMed
  166. Mustafa SB, Castro R, Falck AJ, Petershack JA, Henson BM, Mendoza YM, Choudary A, Seidner SR; ''Protein kinase A and mitogen-activated protein kinase pathways mediate cAMP induction of alpha-epithelial Na+ channels (alpha-ENaC).''; J Cell Physiol, 2008 PubMed
  167. Ibarz G, Oiry C, Carnazzi E, Crespy P, Escrieut C, Fourmy D, Galleyrand JC, Gagne D, Martinez J; ''Cholecystokinin 1 receptor modulates the MEKK1-induced c-Jun trans-activation: structural requirements of the receptor.''; Br J Pharmacol, 2006 PubMed
  168. Poumarat JS, Houillier P, Rismondo C, Roques B, Lazar G, Paillard M, Blanchard A; ''The luminal membrane of rat thick limb expresses AT1 receptor and aminopeptidase activities.''; Kidney Int, 2002 PubMed
  169. Hamilton TA, Handa RK, Harding JW, Wright JW; ''A role for the angiotensin IV/AT4 system in mediating natriuresis in the rat.''; Peptides, 2001 PubMed
  170. Kambayashi Y, Bardhan S, Takahashi K, Tsuzuki S, Inui H, Hamakubo T, Inagami T; ''Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition.''; J Biol Chem, 1993 PubMed
  171. Siragy HM, Inagami T, Carey RM; ''NO and cGMP mediate angiotensin AT2 receptor-induced renal renin inhibition in young rats.''; Am J Physiol Regul Integr Comp Physiol, 2007 PubMed
  172. Nadruz W Jr, Kobarg CB, Kobarg J, Franchini KG; ''c-Jun is regulated by combination of enhanced expression and phosphorylation in acute-overloaded rat heart.''; Am J Physiol Heart Circ Physiol, 2004 PubMed
  173. Cai Y, Stafford LJ, Bryan BA, Mitchell D, Liu M; ''G-protein-activated phospholipase C-beta, new partners for cell polarity proteins Par3 and Par6.''; Oncogene, 2005 PubMed
  174. Becker LK, Etelvino GM, Walther T, Santos RA, Campagnole-Santos MJ; ''Immunofluorescence localization of the receptor Mas in cardiovascular-related areas of the rat brain.''; Am J Physiol Heart Circ Physiol, 2007 PubMed
  175. Jeske NA, Berg KA, Cousins JC, Ferro ES, Clarke WP, Glucksman MJ, Roberts JL; ''Modulation of bradykinin signaling by EP24.15 and EP24.16 in cultured trigeminal ganglia.''; J Neurochem, 2006 PubMed
  176. Tucker BJ, Mundy CA, Maciejewski AR, Printz MP, Ziegler MG, Pelayo JC, Blantz RC; ''Changes in glomerular hemodynamic response to angiotensin II after subacute renal denervation in rats.''; J Clin Invest, 1986 PubMed
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89602view 09:08, 19 September 2016AgustinGVOntology Term : 'renal hypertension' added !
89601view 09:08, 19 September 2016AgustinGVOntology Term : 'hypertension' added !
89042view 12:57, 18 August 2016AgustinGVUpdate available metabolites annotations
88865view 10:22, 16 August 2016AgustinGVSpecify description
88864view 10:21, 16 August 2016AgustinGVSpecify description
88863view 10:17, 16 August 2016AgustinGVUpdate AGT
88862view 10:07, 16 August 2016AgustinGVUpdate AGT as protein
88861view 10:04, 16 August 2016AgustinGVUpdate AGT Gene ID
88860view 09:24, 16 August 2016AgustinGVQuick edit to datanode annotation or property
83030view 19:21, 17 November 2015Mkutmonfix issues in reference list
83029view 19:07, 17 November 2015Mkutmonfix outdated identifiers
70120view 12:23, 12 July 2013MaintBotupdated to 2013 schema
67626view 04:35, 26 June 2013DdiglesOntology Term : 'renin-angiotensin cascade pathway' added !
41750view 19:40, 1 March 2011MaintBotRemoved redundant pathway information and comments
34121view 12:26, 9 December 2009MaintBotAutomatic update of empty xrefs
32412view 10:06, 15 August 2009MaintBotFixed text labels
32069view 06:36, 14 August 2009MaintBotFixed group labels
29243view 00:40, 18 April 2009EveloSome annotations
21469view 04:31, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Renin - Angiotensin System]] moved to [[Pathway:WP376]]: Moved to stable identifier
15828view 01:19, 5 June 2008Thomaschanged type of Reactive oxygen species (ROS) to metabolite
11563view 00:25, 11 April 2008Thomas
11553view 10:09, 10 April 2008MarkRenin - Angiotensin System
11548view 03:17, 10 April 2008Thomas
11535view 00:42, 8 April 2008Markrenin-angiontensin system
11500view 02:42, 3 April 2008Thomasremoved special characters from literature references
11491view 11:05, 2 April 2008ThomasModified description
11490view 10:22, 2 April 2008Mark
11488view 06:29, 2 April 2008ThomasReverted edits by [[Special:Contributions/Mark|Mark]] ([[User_talk:Mark|Talk]]); changed back to last version by [[User:Thomas|Thomas]]
11487view 06:24, 2 April 2008MarkRenin - Angiotensin System
11486view 04:09, 2 April 2008MarkModified description
11476view 08:20, 1 April 2008Thomascosmetic changes
11475view 08:16, 1 April 2008Thomaschanged green to darker shade (more easy to read)
11468view 05:35, 1 April 2008Thomasfixed anchor links
11459view 02:58, 1 April 2008RishiaachaibersingRenin - Angiotensin System
11458view 01:35, 1 April 2008MarkRenin - Angiotensin System
11454view 00:24, 1 April 2008Mark
11277view 07:14, 26 March 2008MarkRenin - Angiotensin System
11272view 06:32, 26 March 2008MarkRenin - Angiotensin System
11271view 06:30, 26 March 2008MarkRenin - Angiotensin System
11270view 06:27, 26 March 2008MarkRenin - Angiotensin System
11269view 06:22, 26 March 2008MarkRenin - Angiotensin System
11227view 05:59, 25 March 2008MarkRenin - Angiotensin System
11226view 05:48, 25 March 2008MarkRenin - Angiotensin System
11225view 05:38, 25 March 2008MarkPeriodical save, work in progress
11148view 03:41, 20 March 2008ThomasModified categories
11138view 13:42, 19 March 2008Thomas
11133view 07:10, 19 March 2008MarkRenin - Angiotensin System
11132view 06:33, 19 March 2008MarkRenin - Angiotensin System
11131view 06:18, 19 March 2008MarkRenin - Angiotensin System
11130view 06:07, 19 March 2008MarkRenin - Angiotensin System

External references


View all...
NameTypeDatabase referenceComment
AC2/3Protein2036 (RGD)
ATF2Protein81647 (Entrez Gene)
AceProtein2493 (RGD)
Ace2Protein728890 (RGD)
Agtr1aProtein2070 (RGD)
Agtr2Protein2072 (RGD)
Angiotensin (1-5)Metabolite
Angiotensin (1-7)Metabolite
Angiotensin (1-9)Metabolite
Angiotensin 1MetaboliteHMDB61196 (HMDB)
Angiotensin IIMetaboliteHMDB01035 (HMDB)
Angiotensin IIIMetaboliteHMDB01036 (HMDB)
Angiotensin IVMetaboliteHMDB01038 (HMDB)
AngiotensinogenProtein2069 (RGD)
AnpepProtein2991 (RGD)
CA2+MetaboliteHMDB00464 (HMDB)
CMA1Protein2365 (RGD)
CTSGProtein1307681 (RGD)
Cpa3Protein2390 (RGD)
ERK1Protein70500 (RGD)
Elk1Protein1598663 (RGD)
EnpepProtein621228 (RGD)
FAKProtein3443 (RGD)
Grb2Protein81504 (Entrez Gene)
IP3MetaboliteHMDB01143 (HMDB)
IkbkbProtein621375 (RGD)
IkbkgProteinENSRNOG00000060936 (Ensembl)
Itpr1Protein2933 (RGD)
Itpr2Protein69649 (RGD)
Itpr3Protein2934 (RGD)
Jak2ProteinENSRNOG00000059968 (Ensembl)
LnpepProtein621752 (RGD)
MEKK1Protein620966 (RGD)
MKK4Protein1307040 (RGD)
MKK7Protein1560043 (RGD)
Mapk10Protein3663 (RGD)
Mapk3ProteinENSRNOG00000053583 (Ensembl)
Mapk8Protein621506 (RGD)
Mapk9Protein628847 (RGD)
Mas1Protein3049 (RGD)
MmeProtein3098 (RGD)
NF-KBProtein727889 (RGD)
NOMetaboliteHMDB03378 (HMDB)
NlnProtein621518 (RGD)
PAK1Protein3250 (RGD)
PAK2Protein61953 (RGD)
PAK3Protein3251 (RGD)
PAK4Protein1307705 (RGD)
PAK6Protein1306213 (RGD)
PAK7Protein1312009 (RGD)
PKAProtein3389 (RGD)
PPtaseProtein62018 (RGD)
PYK2Protein628758 (RGD)
Plcb1Protein3344 (RGD)
PpgbProtein1309070 (RGD)
PrkcqProtein620968 (RGD)
PtgIRProtein292661 (Entrez Gene)
Rac1Protein619755 (RGD)
Raf1Protein24703 (Entrez Gene)
RasProtein2981 (RGD)
ReninProtein3554 (RGD)
STAT1Protein3771 (RGD)
STAT3Protein3772 (RGD)
Thop1Protein68330 (RGD)
c-JunProtein2943 (RGD)
cAMPMetaboliteHMDB00058 (HMDB)
p38Protein3045 (RGD)

Annotated Interactions

<cite>No annotated interactions</cite>