LncRNA-mediated mechanisms of therapeutic resistance (Homo sapiens)

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Chemotherapy Transporter expression Impaired drug expulsion Cell survival HCC cells Drug-resistant cancer cells WNT6 G0/G1 cell cycle arrest HIF1A MEG3 linc-RoR MRUL HOTAIR AK126698 Apoptosis linc-VLDLR UCA1 Cell proliferation P-gp p21 Bcl-xl TP53 Hypoxia Recipient cells EVs EV linc-RoR EV linc-VLDLR Name: LncRNA-mediated mechanisms of therapeutic resistance Organism: Homo sapiens


LncRNA-mediated mechanisms of therapeutic resistance. Mechanisms of tumor cell resistance to chemotherapy or hypoxia involving lncRNA include modulation of drug transporters and elimination, survival signaling pathways, cell cycle progression and DNA repair, sensitization to apoptosis, and modulation of intercellular communication mediated by extracellular vesicles.

This pathway is based on Fig 6 from Parasramka et al: http://www.ncbi.nlm.nih.gov/pubmed/27013343

Quality Tags

Ontology Terms



  1. Parasramka MA, Maji S, Matsuda A, Yan IK, Patel T; ''Long non-coding RNAs as novel targets for therapy in hepatocellular carcinoma.''; Pharmacol Ther, 2016 PubMed


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96967view 18:39, 23 April 2018AlexanderPicocondensed layout
87395view 04:05, 22 July 2016MaintBotadded missing graphids
86056view 16:01, 28 June 2016KhanspersModified description
86053view 14:46, 28 June 2016KhanspersOntology Term : 'antineoplastic drug pathway' added !
86052view 14:44, 28 June 2016KhanspersOntology Term : 'long non-coding RNA pathway' added !
86051view 14:43, 28 June 2016KhanspersOntology Term : 'hepatocellular carcinoma' added !
86050view 14:41, 28 June 2016Khanspersupdated data node color and type
86049view 14:40, 28 June 2016KhanspersModified description
86048view 14:39, 28 June 2016KhanspersNew pathway

External references


View all...
NameTypeDatabase referenceComment
AK126698RnaENSG00000203601 (Ensembl)
ApoptosisPathwayWP254 (WikiPathways)
Bcl-xlGeneProductENSG00000171552 (Ensembl)
Cell proliferationPathway
EV linc-RoRRnaENSG00000258609 (Ensembl)
EV linc-VLDLRRna401491 (Entrez Gene)
G0/G1 cell cycle arrestPathway
HIF1AGeneProductENSG00000100644 (Ensembl)
HOTAIRRnaENSG00000228630 (Ensembl)
MEG3RnaENSG00000214548 (Ensembl)
P-gpGeneProductENSG00000085563 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
UCA1RnaENSG00000214049 (Ensembl)
WNT6GeneProductENSG00000115596 (Ensembl)
linc-RoRRnaENSG00000258609 (Ensembl)
linc-VLDLRRna401491 (Entrez Gene)
p21GeneProductENSG00000124762 (Ensembl)

Annotated Interactions

<cite>No annotated interactions</cite>