Wnt/beta-catenin Signaling Pathway in Leukemia (Homo sapiens)

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Transcription Absence of Wnt Pathway Activation Methylation of WIF1 promoter in Leukemia Activation of Wnt Pathway Proteosomal Degradation DKK c-MYC PPARD cyclin-D1 FLT3 Catenin beta-1 WIF1 SALL4 Phosphate AKT AML1 RUNX1T1 Frizzled WNT LRP6 LRP5 BCL9 PYGO PLZF RARA Junction plakoglobin Catenin beta-1 RARA PML TCF LEF GSK3B Phosphate APC CK1 AXIN Name: Wnt/beta-catenin Signaling Pathway in Leukemia Organism: Homo sapiens


The Wnt/Beta-catenin pathway mediates the transcription of proteins important for maintenance and growth of hematopoietic stem cells. The inhibition of Wnt leads to protein degradation through Beta-Catenin activation by the Axin/APC/CK1/GSK3B protein complex. This pathway is based on figure 5 from Misaghian et al.

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Ontology Terms



  1. Misaghian N, Ligresti G, Steelman LS, Bertrand FE, Bäsecke J, Libra M, Nicoletti F, Stivala F, Milella M, Tafuri A, Cervello M, Martelli AM, McCubrey JA; ''Targeting the leukemic stem cell: the Holy Grail of leukemia therapy.''; Leukemia, 2009 PubMed


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97640view 07:30, 31 May 2018AMTanOntology Term : 'leukemia' added !
97530view 07:22, 24 May 2018Mick Eikelhof
97528view 07:19, 24 May 2018Mick Eikelhof
97520view 06:54, 24 May 2018Mick Eikelhofupdated c-MYC annotation to Ensembl
90078view 16:46, 12 October 2016KhanspersModified title
87606view 01:54, 25 July 2016LindarieswijkOntology Term : 'altered Wnt signaling pathway' added !
85928view 11:25, 21 June 2016AAR&CoFixed Unconnected Line
85927view 11:24, 21 June 2016AAR&CoModified description
85821view 11:54, 15 June 2016AAR&CoAdd Citation
85814view 09:10, 15 June 2016AAR&CoModified description
85813view 08:56, 15 June 2016AAR&CoPeriodical save, work in progress
85812view 08:25, 15 June 2016AAR&CoNew pathway

External references


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NameTypeDatabase referenceComment
AKTGeneProductENSG00000142208 (Ensembl)Akt Not Specified
AML1GeneProductLRG_482 (Ensembl)
APCGeneProductENSG00000134982 (Ensembl)
AXINGeneProductENSG00000168646 (Ensembl)
BCL9GeneProductENSG00000116128 (Ensembl)
CK1GeneProductENSG00000113712 (Ensembl)
Catenin beta-1ProteinB4DGU4 (Uniprot-TrEMBL)
DKKGeneProductENSG00000107984 (Ensembl)DKK Not Specified
FLT3GeneProductENSG00000122025 (Ensembl)
FrizzledProteinE5RGK8 (Uniprot-TrEMBL)Frizzled Not Specified
GSK3BGeneProductENSG00000082701 (Ensembl)
Junction plakoglobinProteinP14923 (Uniprot-TrEMBL)
LEFGeneProductENSG00000138795 (Ensembl)LEF Not Specified
LRP5GeneProductENSG00000162337 (Ensembl)
LRP6GeneProductENSG00000070018 (Ensembl)
PLZFGeneProductENSG00000109906 (Ensembl)
PMLGeneProductENSG00000140464 (Ensembl)
PPARDGeneProductENSG00000112033 (Ensembl)
PYGOGeneProductENSG00000171016 (Ensembl)PYGO Not Specified
PhosphateMetaboliteHMDB01429 (HMDB)
RARAGeneProductENSG00000131759 (Ensembl)
RUNX1T1GeneProductENSG00000079102 (Ensembl)
SALL4GeneProductENSG00000101115 (Ensembl)
TCFGeneProductENSG00000071564 (Ensembl)TCF Not Specified
WIF1GeneProductENSG00000156076 (Ensembl)
WNTGeneProductENSG00000125084 (Ensembl)Wnt Not Specified
c-MYCGeneProductENSG00000136997 (Ensembl)
cyclin-D1ProteinP24385 (Uniprot-TrEMBL)

Annotated Interactions

<cite>No annotated interactions</cite>