Photodynamic therapy-induced NF-kB survival signaling (Homo sapiens)

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ROS / Hypoxia X Proliferation CCND1 VEGFA IL1A IL1B IL2 IL6 IL8 CSF2 TNF Inflammation PTGS2 ICAM1 VCAM1 CXCL2 CD40LG SELE EGLN2 IKBKB CHUK NFKB1 RELA REL NFKB2 RELB X Angiogenesis MMP3 MMP9 VEGFA MMP2 MMP1 PTGS2 TRAF6 TNF TNFRSF1A Gene transcription NFKB1 RELA REL NFKB2 RELB PTGS2 CFLAR BIRC2 BIRC5 BIRC3 BCL2A1 BCL2L2 Survival Name: Photodynamic therapy-induced NF-kB survival signaling Organism: Homo sapiens


Photodynamic therapy may induce a pro-inflammatory and angiogenic response mediated by NF-κB.

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Ontology Terms



  1. Weijer R, Broekgaarden M, van Golen RF, Bulle E, Nieuwenhuis E, Jongejan A, Moerland PD, van Kampen AH, van Gulik TM, Heger M; ''Low-power photodynamic therapy induces survival signaling in perihilar cholangiocarcinoma cells.''; BMC Cancer, 2015 PubMed
  2. Broekgaarden M, Weijer R, van Gulik TM, Hamblin MR, Heger M; ''Tumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategies.''; Cancer Metastasis Rev, 2015 PubMed


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88316view 08:37, 1 August 2016FehrhartOntology Term : 'altered regulatory pathway' added !
88150view 11:24, 26 July 2016AlexanderPicoModified title
86063view 16:29, 28 June 2016KhanspersOntology Term : 'cancer' added !
85991view 12:28, 22 June 2016KhanspersModified title
84547view 12:15, 1 March 2016MaintBotTwo more groups
84546view 12:14, 1 March 2016MaintBotConnected interactions and created groups
84535view 13:08, 29 February 2016RuudweijerAdded reference.
84494view 00:29, 26 February 2016RuudweijerModified title
84493view 00:28, 26 February 2016RuudweijerModified description
84463view 11:15, 25 February 2016RuudweijerNew pathway

External references


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NameTypeDatabase referenceComment
BCL2A1GeneProduct597 (Entrez Gene)
BCL2L2GeneProduct599 (Entrez Gene)
BIRC2GeneProduct329 (Entrez Gene)
BIRC3GeneProduct330 (Entrez Gene)
BIRC5GeneProduct332 (Entrez Gene)
CCND1GeneProduct595 (Entrez Gene)
CD40LGGeneProduct959 (Entrez Gene)
CFLARGeneProduct8837 (Entrez Gene)
CHUKGeneProduct1147 (Entrez Gene)
CSF2GeneProduct1437 (Entrez Gene)
CXCL2GeneProduct2920 (Entrez Gene)
EGLN2GeneProduct112398 (Entrez Gene)
ICAM1GeneProduct3383 (Entrez Gene)
IKBKBGeneProduct3551 (Entrez Gene)
IL1AGeneProduct3552 (Entrez Gene)
IL1BGeneProduct3553 (Entrez Gene)
IL2GeneProduct3558 (Entrez Gene)
IL6GeneProduct3569 (Entrez Gene)
IL8GeneProduct3576 (Entrez Gene)
MMP1GeneProduct4312 (Entrez Gene)
MMP2GeneProduct4313 (Entrez Gene)
MMP3GeneProduct4314 (Entrez Gene)
MMP9GeneProduct4318 (Entrez Gene)
NFKB1GeneProduct4790 (Entrez Gene)
NFKB2GeneProduct4791 (Entrez Gene)
PTGS2GeneProduct5743 (Entrez Gene)
RELGeneProduct5966 (Entrez Gene)
RELAGeneProduct5970 (Entrez Gene)
RELBGeneProduct5971 (Entrez Gene)
SELEGeneProduct6401 (Entrez Gene)
TNFGeneProduct7124 (Entrez Gene)
TNFRSF1AGeneProduct7132 (Entrez Gene)
TRAF6GeneProduct7189 (Entrez Gene)
VCAM1GeneProduct7412 (Entrez Gene)
VEGFAGeneProduct7422 (Entrez Gene)

Annotated Interactions

<cite>No annotated interactions</cite>