Fanconi Anemia Pathway (Homo sapiens)

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cytosol nucleoplasm ICL-DNA FANCM:FAAP24 APITD1:STRA13 octamer FANCM:FAAP24:APITD1:STRA13:ICL-DNA FANCL FANCB FANCE FANCG FAAP100 FAAP20 FANCF FANCC FANCA FA Core Complex:ICL-DNA FANCD2:FANCI FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA UBE2T Ub MonoUb:K91,K182-UBE2T MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA FANCD2 FANCI FAAP24 FANCM SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) FAN1 ERCC1:ERCC4 DCLRE1A,DCLRE1B MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA POLN MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN dNTP Distorted dsDNA MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI DNA double-strand break ends PPi DNA Double-Strand Break Repair Nucleotide Excision Repair USP1:ZBTB32 RPA heterotrimer ATR:ATRIP FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA p-RPA heterotrimer ATP ADP p-FANCD2:p-FANCI p-FA Core Complex p-FA Core Complex:ICL-DNA FAAP24 FANCM APITD1 STRA13 ICL-DNA FAAP24 FANCM APITD1 STRA13 FAAP24 FANCM APITD1 STRA13 FAAP100 FAAP20 FANCA FANCB FANCC FANCE FANCF FANCG FANCL ICL-DNA FANCD2 FANCI UBE2T FAAP24 FANCM APITD1 STRA13 FAAP100 FAAP20 FANCA FANCB FANCC FANCE FANCF FANCG FANCL ICL-DNA FANCD2 FANCI RPS27A(1-76) UBA52(1-76) UBB(1-76) UBB(77-152) UBB(153-228) UBC(1-76) UBC(77-152) UBC(153-228) UBC(229-304) UBC(305-380) UBC(381-456) UBC(457-532) UBC(533-608) UBC(609-684) MonoUb-K91,K182-UBE2T RPS27A(1-76) UBA52(1-76) UBB(1-76) UBB(77-152) UBB(153-228) UBC(1-76) UBC(77-152) UBC(153-228) UBC(229-304) UBC(305-380) UBC(381-456) UBC(457-532) UBC(533-608) UBC(609-684) RPS27A(1-76) UBA52(1-76) UBB(1-76) UBB(77-152) UBB(153-228) UBC(1-76) UBC(77-152) UBC(153-228) UBC(229-304) UBC(305-380) UBC(381-456) UBC(457-532) UBC(533-608) UBC(609-684) MonoUb-K561,p-T691,S717-FANCD2 MonoUb-K523,p-4S-FANCI ICL-DNA APITD1 STRA13 FAAP100 FAAP20 FANCA FANCB FANCC FANCE FANCF FANCG FANCL FAAP24 p-S1045-FANCM SLX1A SLX4 MUS81 EME1 EME2 ERCC1 ERCC4 DCLRE1A DCLRE1B RPS27A(1-76) UBA52(1-76) UBB(1-76) UBB(77-152) UBB(153-228) UBC(1-76) UBC(77-152) UBC(153-228) UBC(229-304) UBC(305-380) UBC(381-456) UBC(457-532) UBC(533-608) UBC(609-684) MonoUb-K561,p-T691,S717-FANCD2 MonoUb-K523,p-4S-FANCI ICL-DNA APITD1 STRA13 FAAP100 FAAP20 FANCA FANCB FANCC FANCE FANCF FANCG FANCL FAAP24 p-S1045-FANCM SLX1A SLX4 MUS81 EME1 EME2 DCLRE1A DCLRE1B ERCC1 ERCC4 FAN1 FANCA FANCB FANCC FANCE FANCF FANCG FANCL FANCM FAAP100 FAAP24 FAAP20 RPS27A(1-76) UBA52(1-76) UBB(1-76) UBB(77-152) UBB(153-228) UBC(1-76) UBC(77-152) UBC(153-228) UBC(229-304) UBC(305-380) UBC(381-456) UBC(457-532) UBC(533-608) UBC(609-684) MonoUb-K561,p-T691,S717-FANCD2 MonoUb-K523,p-4S-FANCI Unhooked ICL-DNA POLN FANCA FANCB FANCC FANCE FANCF FANCG FANCL FANCM FAAP100 FAAP24 FAAP20 RPS27A(1-76) UBA52(1-76) UBB(1-76) UBB(77-152) UBB(153-228) UBC(1-76) UBC(77-152) UBC(153-228) UBC(229-304) UBC(305-380) UBC(381-456) UBC(457-532) UBC(533-608) UBC(609-684) MonoUb-K561,p-T691,S717-FANCD2 MonoUb-K523,p-4S-FANCI Unhooked ICL-DNA RPS27A(1-76) UBA52(1-76) UBB(1-76) UBB(77-152) UBB(153-228) UBC(1-76) UBC(77-152) UBC(153-228) UBC(229-304) UBC(305-380) UBC(381-456) UBC(457-532) UBC(533-608) UBC(609-684) MonoUb-K561,p-T691,S717-FANCD2 MonoUb-K523,p-4S-FANCI ZBTB32 USP1 RPA2 RPA3 RPA1 ATRIP ATR UBE2T FAAP24 FANCM APITD1 STRA13 FAAP100 FAAP20 FANCA FANCB FANCC FANCE FANCF FANCG FANCL ICL-DNA FANCD2 FANCI ATRIP ATR RPA2 RPA3 RPA1 UBE2T p-4S-FANCI p-T691,S717-FANCD2 ICL-DNA APITD1 STRA13 FAAP100 FAAP20 FANCA FANCB FANCC FANCE FANCF FANCG FANCL FAAP24 p-S1045-FANCM RPA3 RPA1 p-S33-RPA2 p-4S-FANCI p-T691,S717-FANCD2 APITD1 STRA13 FAAP100 FAAP20 FANCA FANCB FANCC FANCE FANCF FANCG FANCL FAAP24 p-S1045-FANCM ICL-DNA APITD1 STRA13 FAAP100 FAAP20 FANCA FANCB