Ovarian Infertility Genes (Homo sapiens)

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Granulosa Cell Cytoplasm Nucleus Oocyte Nucleus Ooplasm BMPR1B GDF9 SMPD1 DAZL GJA4 GJA4 INHA SMAD3 PTGER2 SMPD1 CYP19A1 SYNE2 FIGLA DMC1 ATM MLH1 MSH5 ZP3 ZP3 ZP2 PGR ESR2 VDR NR5A1 TF2D NCOR1 NRIP1 EGR1 CEBPB CDKN1B CCND2 CDK4 PRLR FSHR LHCGR GDF9 INHA Name: Ovarian Infertility Genes License: CC BY 2.0 Last Modified: 10/16/2013 Organism: Homo sapiens


Ovarian bottleneck genes associated with infertility. A valuable approach to the study of infertility is the comparison of mutations of individual human and mouse genes associated with infertility phenotypes. The individual gene pages in the OKdb (Ovarian Kaleidoscope Database: http://ovary.stanford.edu) contain information on associated fertility phenotypes sorted by ovarian and nonovarian defects and by subfertility or infertility. If one searches for null mutations (under mutation type) causing infertility (infertile - ovarian defect, under female fertility status) in mice (under species), 44 gene entries are found. The expression of these infertility genes in the oocyte and granulosa cells together with their cellular localization is presented in Ovarian Infertility gene map. The theca cell genes are not presented because most publications emphasize granulosa cell studies.

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88253view 07:28, 1 August 2016FehrhartOntology Term : 'urogenital disease pathway' added !
72115view 16:04, 24 October 2013AlexanderPicoadded xref for FIG-ALPHA
71243view 12:57, 16 October 2013MaintBotAutomated update of data sources
61681view 14:45, 16 April 2013MaintBotremoved data source without identifer
61680view 14:45, 16 April 2013MaintBotchanged data source swissprot to uniprot
54696view 05:30, 7 December 2012AndraCorrected ID after RDF Tidy
45314view 13:06, 7 October 2011Khanspersremoved old comment
45312view 13:05, 7 October 2011KhanspersModified description
45311view 13:04, 7 October 2011KhanspersOntology Term : 'infertility' added !
45310view 13:04, 7 October 2011KhanspersOntology Term : 'granulosa cell' added !
45309view 13:04, 7 October 2011KhanspersOntology Term : 'oocyte' added !
45020view 11:38, 6 October 2011AlexanderPicoconnected lines
41052view 16:16, 1 March 2011MaintBotRemoved redundant pathway information and comments
38776view 16:58, 23 September 2010KhanspersChanged graphics
35762view 17:08, 12 February 2010KhanspersMoved from Comments to Description
35761view 17:07, 12 February 2010KhanspersModified description
34502view 16:08, 16 December 2009KhanspersAdded connectors
32057view 06:33, 14 August 2009MaintBotFixed group labels
20749view 04:29, 14 November 2008MaintBot[[Pathway:Homo sapiens:Ovarian Infertility Genes]] moved to [[Pathway:WP34]]: Moved to stable identifier
13990view 07:24, 20 May 2008Thomasgrouped genes
13028view 04:07, 17 May 2008MaintBotSticky edges patch by Sjoerd
8312view 06:46, 7 January 2008MaintBot[[Pathway:Human:Ovarian Infertility Genes]] moved to [[Pathway:Homo sapiens:Ovarian Infertility Genes]]: Renaming species
7774view 09:16, 18 December 2007MaintBotfixed category names
7283view 05:41, 4 November 2007MaintBotAdded categories to GPML
19528view 15:18, 22 May 2007A.Hsuehgpml file for [[Human:Ovarian_Infertility_Genes]]
6359view 15:18, 22 May 2007I.BenShlomogpml file for [[Human:Ovarian_Infertility_Genes]]

External references


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NameTypeDatabase referenceComment
ATMGeneProduct472 (Entrez Gene)
BMPR1BGeneProduct658 (Entrez Gene)
CCND2GeneProduct894 (Entrez Gene)
CDK4GeneProduct1019 (Entrez Gene)
CDKN1BGeneProduct1027 (Entrez Gene)
CEBPBGeneProduct1051 (Entrez Gene)
CYP19A1GeneProduct1588 (Entrez Gene)
DAZLGeneProduct1618 (Entrez Gene)
DMC1GeneProduct11144 (Entrez Gene)
EGR1GeneProduct1958 (Entrez Gene)
ESR2GeneProduct2100 (Entrez Gene)
FIGLAGeneProduct344018 (Entrez Gene)
FSHRGeneProduct2492 (Entrez Gene)
GDF9GeneProduct2661 (Entrez Gene)
GJA4GeneProduct2701 (Entrez Gene)
INHAGeneProduct3623 (Entrez Gene)
LHCGRGeneProduct3973 (Entrez Gene)
MLH1GeneProduct4292 (Entrez Gene)
MSH5GeneProduct4439 (Entrez Gene)
NCOR1GeneProduct9611 (Entrez Gene)
NR5A1GeneProduct2516 (Entrez Gene)
NRIP1GeneProduct8204 (Entrez Gene)
PGRGeneProduct5241 (Entrez Gene)
PRLRGeneProduct5618 (Entrez Gene)
PTGER2GeneProduct5732 (Entrez Gene)
SMAD3GeneProduct4088 (Entrez Gene)
SMPD1GeneProduct6609 (Entrez Gene)
SYNE2GeneProduct23224 (Entrez Gene)
TF2DGeneProductP20226 (Uniprot-TrEMBL)
VDRGeneProduct7421 (Entrez Gene)
ZP2GeneProduct7783 (Entrez Gene)
ZP3GeneProduct7784 (Entrez Gene)

Annotated Interactions

<cite>No annotated interactions</cite>