EV release from cardiac cells and their functional effects (Homo sapiens)

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MIR143 hsa-miR-145-5p MIR126 hsa-miR-146a-5p TNFalpha mRNA HSP70 CD63 HSP60 HSC70 HSC90 Multiple targets DNA RNA Apoptotic body Serum starvation Monocyte (THP-1) Decreased metabolic activity Hypoxia Migration ERBB4 Ox-LDL Homocysteine MIR146A MIR150 KLF2 Ethanol CXCL12 Prolactin RGS16 C-Myb Ethanol Serum starvation Endothelial cells (HUVECs, HMEC-1, and rat aortic endothelial cells) Sheer stress Smooth muscle cells (HASMCs) Cardiomyocyte (NRVM, adult rat cardiomyocyte, HL-1) Cardiomyocyte (NRVM) DNA RNA Fibroblast (NIH-3T3) Apoptosis Name: EV release from cardiac cells and their functional effects Organism: Homo sapiens


Summary of reported EV release from cardiac cells in culture and their functional effects. EV release has been reported in numerous cell lines and primary cultures, both at baseline and in response to stimuli. Transfer of EVs between cell types has been demonstrated as well as delivery of cargo.

Note that this pathway represents a review of multiple studies in multiple organisms. This pathway displays the human orthologs.

HUVEC: human aortic endothelial cell

HMEC-1: human microvascular endothelial cell

HASMC: human aortic smooth muscle cell

NRVM: neonatal rat ventricular myocyte.

Adapted from Danielson KM, Das S. Extracellular Vesicles in Heart Disease: Excitement for the Future? Exosomes Microvesicles, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25429310

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Ontology Terms



  1. Zhang Y, Liu D, Chen X, Li J, Li L, Bian Z, Sun F, Lu J, Yin Y, Cai X, Sun Q, Wang K, Ba Y, Wang Q, Wang D, Yang J, Liu P, Xu T, Yan Q, Zhang J, Zen K, Zhang CY; ''Secreted monocytic miR-150 enhances targeted endothelial cell migration.''; Mol Cell, 2010 PubMed
  2. Zhan R, Leng X, Liu X, Wang X, Gong J, Yan L, Wang L, Wang Y, Qian LJ; ''Heat shock protein 70 is secreted from endothelial cells by a non-classical pathway involving exosomes.''; Biochem Biophys Res Commun, 2009 PubMed
  3. Danielson KM, Das S; ''Extracellular Vesicles in Heart Disease: Excitement for the Future ?''; Exosomes Microvesicles, 2014 PubMed
  4. Malik ZA, Kott KS, Poe AJ, Kuo T, Chen L, Ferrara KW, Knowlton AA; ''Cardiac myocyte exosomes: stability, HSP60, and proteomics.''; Am J Physiol Heart Circ Physiol, 2013 PubMed
  5. Yu X, Deng L, Wang D, Li N, Chen X, Cheng X, Yuan J, Gao X, Liao M, Wang M, Liao Y; ''Mechanism of TNF-α autocrine effects in hypoxic cardiomyocytes: initiated by hypoxia inducible factor 1α, presented by exosomes.''; J Mol Cell Cardiol, 2012 PubMed
  6. Halkein J, Tabruyn SP, Ricke-Hoch M, Haghikia A, Nguyen NQ, Scherr M, Castermans K, Malvaux L, Lambert V, Thiry M, Sliwa K, Noel A, Martial JA, Hilfiker-Kleiner D, Struman I; ''MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy.''; J Clin Invest, 2013 PubMed
  7. Gupta S, Knowlton AA; ''HSP60 trafficking in adult cardiac myocytes: role of the exosomal pathway.''; Am J Physiol Heart Circ Physiol, 2007 PubMed
  8. Zernecke A, Bidzhekov K, Noels H, Shagdarsuren E, Gan L, Denecke B, Hristov M, Köppel T, Jahantigh MN, Lutgens E, Wang S, Olson EN, Schober A, Weber C; ''Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection.''; Sci Signal, 2009 PubMed
  9. Hergenreider E, Heydt S, Tréguer K, Boettger T, Horrevoets AJ, Zeiher AM, Scheffer MP, Frangakis AS, Yin X, Mayr M, Braun T, Urbich C, Boon RA, Dimmeler S; ''Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs.''; Nat Cell Biol, 2012 PubMed
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96966view 17:58, 23 April 2018AlexanderPicoModified description
88048view 06:43, 25 July 2016SusanOntology Term : 'regulatory pathway' added !
87383view 04:05, 22 July 2016MaintBotadded missing graphids
83780view 08:22, 4 December 2015SusanChange miRNA names and IDs
81231view 12:25, 6 August 2015Khanspersfixed unconnected interactions
81157view 17:38, 28 July 2015KhanspersModified description
81156view 17:38, 28 July 2015KhanspersModified description
81155view 17:30, 28 July 2015KhanspersAdded literature references
81144view 14:54, 27 July 2015KhanspersModified description
81143view 14:54, 27 July 2015KhanspersModified description
81142view 14:53, 27 July 2015KhanspersModified description
81141view 14:51, 27 July 2015KhanspersNew pathway

External references


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NameTypeDatabase referenceComment
C-MybGeneProductENSG00000118513 (Ensembl)
CXCL12GeneProductENSG00000107562 (Ensembl)
ERBB4GeneProductENSG00000178568 (Ensembl)
EthanolMetaboliteHMDB00108 (HMDB)
HomocysteineMetaboliteHMDB00742 (HMDB)
KLF2GeneProductENSG00000127528 (Ensembl)
MIR126RnaENSG00000199161 (Ensembl)
MIR143RnaENSG00000208035 (Ensembl)
MIR146ARnaENSG00000207936 (Ensembl)
MIR150RnaENSG00000207782 (Ensembl)
Ox-LDLMetaboliteCHEBI:60151 (ChEBI)
ProlactinGeneProductENSG00000172179 (Ensembl)
RGS16GeneProductENSG00000143333 (Ensembl)
TNFalpha mRNARna7124 (Entrez Gene)
hsa-miR-145-5pGeneProductMIMAT0000437 (miRBase mature sequence)
hsa-miR-146a-5pRnaMIMAT0000449 (miRBase mature sequence)

Annotated Interactions

<cite>No annotated interactions</cite>