Endothelin Pathways (Bos taurus)

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Sensory motor nerve Vasocontriction ATP2A2 NOS3 NO L-Arginine Citrulline COII PGI2 Arachidonic acid EDHF K+ channel Ca2+ channel K+ PTGIR ADCY10 ATP cAMP RIIAD1 ADRA1A K+ CT CALCRL RAMP1 NPY NPY1R sGC GTP cGMP Ca2+ channel EDN1 ECE1 IP3 CNN1 PRKCA GNA15 GNB5 GNG13 MYL1 Big ET1 MAP2K1 EDNRA MYLK DAG MAPK1 EDNRB Furin-like protease RAF1 PLCB1 IP3R Pre-pro ET1 CAD Ca2+ CaM PIP2 Pre-pro ET1 EDN1 Ca2+ PMCA Ca2+ EDNRB GNA15 GNB5 GNG13 PLCB1 PIP2 IP3 DAG Ca2+ Ca2+ Ca2+ channel IP3R NO PGI2 PRKCA Ca2+ K+ GNAS GNB5 GNG13 GNA15 GNB5 GNG13 ADRB1 GNAS GNB5 GNG13 Sympathic nerve Endothelial cell Smooth muscle cell K+ CT CT GNAS GNB5 GNG13 K+ K+ NPY NPY GNAI1 GNB5 GNG13 NO NO Ca2+ Cellular growth and survival Name: Endothelin Pathways Last Modified: 10/17/2013 Organism: Bos taurus


Description

Endothelin-1 is a bicyclic 21 amino acid peptide, produced primarily in the endothelium. It is a potent stimulus of long-lasting and persistent vasoconstriction. It also has a role as a stimulus of inflammation, oxidative stress and cellular proliferation.

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Ontology Terms

<OntologyTags></OntologyTags>

Bibliography

No bibliography

History

RevisionActionTimeUserComment
80875view 08:29, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADCY10GeneProductENSBTAG00000001052 (Ensembl)
  • adenylate cyclase
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000143199
ADRA1AGeneProductENSBTAG00000031632 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000120907
ADRB1GeneProductENSBTAG00000001242 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000043591
ATP2A2GeneProductENSBTAG00000001398 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000174437
ATPMetaboliteHMDB01532 (HMDB)
Arachidonic acidMetaboliteHMDB01043 (HMDB)
Big ET1Protein
CADGeneProductENSBTAG00000017894 (Ensembl)
  • Calmodulin binding protein; tonically inhibits the ATPase activity of myosin in smoothe muscle; mediating factor for Ca2+ dependent inhibition of smooth muscle contraction
  • Type your comment here
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000084774
CALCRLGeneProductENSBTAG00000008483 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000064989
CNN1GeneProductENSBTAG00000011207 (Ensembl)
  • Calponin; tonically inhibits the ATPase activity of myosin in smooth muscle
  • Type your comment here
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130176
COIIGeneProductENSBTAG00000043556 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4513
CTGeneProductENSBTAG00000047380 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000110680
Ca2+ channelGeneProduct
Ca2+MetaboliteHMDB00464 (HMDB)
CaMGeneProduct
CitrullineMetaboliteHMDB00904 (HMDB)
DAGMetaboliteHMDB07008 (HMDB)
ECE1GeneProductENSBTAG00000002977 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117298
EDHFProtein
EDN1GeneProductENSBTAG00000008096 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000078401
EDNRAGeneProductENSBTAG00000013674 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000151617
EDNRBGeneProductENSBTAG00000005299 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136160
Furin-like proteaseProtein
GNA15GeneProductENSBTAG00000019988 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000060558
GNAI1GeneProductENSBTAG00000002714 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000127955
GNASGeneProductENSBTAG00000017475 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000087460
GNB5GeneProductENSBTAG00000003762 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000069966
GNG13GeneProductENSBTAG00000033526 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000127588
GTPMetaboliteHMDB01440 (HMDB)
IP3MetaboliteHMDB01059 (HMDB)
IP3RProtein
K+ channelProtein
K+MetaboliteHMDB00586 (HMDB)
L-ArginineMetaboliteHMDB00517 (HMDB)
MAP2K1GeneProductENSBTAG00000033983 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169032
MAPK1GeneProductENSBTAG00000010312 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100030
MYL1GeneProductENSBTAG00000009707 (Ensembl)
  • myosine light chain
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168530
MYLKGeneProductENSBTAG00000014567 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000065534
NOMetaboliteHMDB03378 (HMDB)
NOS3GeneProductENSBTAG00000017680 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164867
NPY1RGeneProductENSBTAG00000047586 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164128
NPYGeneProductENSBTAG00000004503 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000122585
PGI2Metabolite
PIP2MetaboliteHMDB10032 (HMDB)
PLCB1GeneProductENSBTAG00000008338 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000182621
PMCAProtein
PRKCAGeneProductENSBTAG00000001061 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000154229
PTGIRGeneProductENSBTAG00000014585 (Ensembl)
  • Prostaglandin I2 Receptor
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160013
Pre-pro ET1Protein
RAF1GeneProductENSBTAG00000045748 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132155
RAMP1GeneProductENSBTAG00000011534 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132329
RIIAD1GeneProductENSBTAG00000032733 (Ensembl)HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000178796
cAMPMetaboliteHMDB00058 (HMDB)
cGMPMetaboliteHMDB01314 (HMDB)
sGCGeneProduct

Annotated Interactions

<cite>No annotated interactions</cite>