Role of lipid metabolism in C. elegans (Caenorhabditis elegans)

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Fat storage Well fed animals Key Inhibits LPD-3 CCO-1/LPD-4 LPD-5 LPD-6 Unfolded protein response (UPR) ATP SIR-2.1/SIR2.1 LPD-9 MAC-1 LPD-8 LPD-7 SBP-1 CBP-1 HSP-4 ATGL-1 Phosphorylated AAK-2 PAR-4 KRI-1 lips-7 DAF-16 CTBP-1 DAF-2 Proposed to inhibit Proposed to stimulate Stimulates DAF-16 lipl-4 DAF-16 translocation to nucleus Starvation fil-1 lips-7 Conditional stimulation IRE-1 Dauer animals Phosphorylation of AAK-2 AAK-2 Regulates Phosphorylates LIFESPAN Positively influences Negatively influences Name: Role of lipid metabolism in C. elegans Organism: Caenorhabditis elegans


Description

"Lipases regulate life span in C. elegans. Several lipases, K04A8.5, LIPS-7, FIL-1, FIL-2, and ATGL-1, have been demonstrated to influence the lifespan of C. elegans. The figure depicts the mechanisms by which these lipases are regulated and the pathways by which they affect longevity. Well fed animals were shown to live longer during germline stem cell (GSC) arrest. This phenotype depends on K04A8.5 lipase activity, which was suggested to be promoted by the KRI-1/DAF-16 signalling pathway. Additionally, a ctbp-1 mutant also displayed increased lifespan during well fed conditions. It was proposed that this NAD(H)-dependent corepressor, CTBP-1, acted downstream of SIR2.1 and DAF-2 but up stream of DAF-16. One of its target genes lips-7 encodes a lipase and is required for the increased life span of ctbp-1 mutants. IRE-1 and HSP-4, which are normally involved in the unfolded protein response, are required for expression of FIL-1 and FIL-2 during starvation. The two transcription regulators, SBP-1 and CBP-1, are likewise required for FIL-1 and FIL-2 induction. The a2 catalytic subunit of AMP-dependent kinase (AMPK) regulates the activity of the C. elegans paralogue of the adipose triglyceride lipase, ATGL-1, during the dauer stage. AMPK is regulated by AMP levels and by phosphorylation by human homologue of LKB1 kinase PAR-4." Fig 1. Elle, et al., 2010. Fat storage genes identified in McKay et al., 2003.

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Ontology Terms

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Bibliography

  1. Elle IC, Olsen LC, Pultz D, Rødkaer SV, Faergeman NJ; ''Something worth dyeing for: molecular tools for the dissection of lipid metabolism in Caenorhabditis elegans.''; FEBS Lett, 2010 PubMed
  2. McKay RM, McKay JP, Avery L, Graff JM; ''C elegans: a model for exploring the genetics of fat storage.''; Dev Cell, 2003 PubMed

History

RevisionActionTimeUserComment
87643view 01:54, 25 July 2016LindarieswijkOntology Term : 'lipid metabolic pathway' added !
79936view 10:42, 27 April 2015Kyookadded WP2578 to UPR node
79874view 16:52, 22 April 2015KyookModified description
79873view 16:48, 22 April 2015KyookNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AAK-2GeneProductT01C8.1 (WormBase)
ATGL-1GeneProductWBGene00015484 (WormBase)
ATPMetabolite15422 (ChEBI)
CBP-1GeneProductR10E11.1 (WormBase)
CCO-1/LPD-4GeneProductF26E4.9 (WormBase)
CTBP-1GeneProductF49E10.5 (WormBase)
DAF-16

translocation

to nucleus
GeneProductR13H8.1 (WormBase)
DAF-16GeneProductR13H8.1 (WormBase)
DAF-2GeneProductY55D5A.5 (WormBase)
HSP-4GeneProductF43E2.8 (WormBase)
IRE-1GeneProductC41C4.4 (WormBase)
KRI-1GeneProductZK265.1 (WormBase)
LIFESPAN
LPD-3GeneProductY47G6A.23 (WormBase)
LPD-5GeneProductZK973.10 (WormBase)
LPD-6GeneProductK09H9.6 (WormBase)
LPD-7GeneProductR13A5.12 (WormBase)
LPD-8GeneProductR10H10.1 (WormBase)
LPD-9GeneProductT21C9.5 (WormBase)
MAC-1GeneProductY48C3A.7 (WormBase)
PAR-4GeneProductY59A8B.14 (WormBase)
Phosphorylated AAK-2GeneProductT01C8.1 (WormBase)
Phosphorylation of AAK-2GeneProductR13H8.1 (WormBase)
SBP-1GeneProductY47D3B.7 (WormBase)
SIR-2.1/SIR2.1GeneProductR11A8.4 (WormBase)
Unfolded protein response (UPR)PathwayWP2578 (WikiPathways)
fil-1GeneProductT01C3.4 (WormBase)
lipl-4GeneProductK04A8.5 (WormBase)
lips-7GeneProductC09E8.2 (WormBase)

Annotated Interactions

<cite>No annotated interactions</cite>