Selenium Metabolism and Selenoproteins (Homo sapiens)

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SeC SBP2 Phosphoseryl-tRNA[ser](sec) Seryl-tRNA[ser](sec) Sec tRNA[ser]sec Selenocysteyl-tRNA sec Diet methyl transferase demethylation coding region AUG STOP nucleus Selenoproteins Se = Selenium, SeMet = SelenoMethionine, SeC = Selcysteine, H2Se = Selenide, GSH = gluthatione, Trx = Thioredoxin GSH Body proteins TrX SeC Biosynthesis SeC INORGANIC Se Selenite Selenate ORGANIC Se SeMet SeC Transcription Factors Sp1 Sp3 JUN Pouf2f1 Nfe2l2 NFKB-p105 CREM FOS NFKB-p65 Antioxidant enzymes GPX1 GPX2 GPX4 SepW GPX3 GPX6 SelK SepX1 Redox signalling TXNRD1 TXNRD2 TXNRD3 Thyroid hormone metabolism DIO1 DIO2 DIO3 Sec synthesis SPS2 Se transport and storage SEPP1 Protein folding Sep15 SelM SEPN1 SelS Unkown function SelH SelI SelO SelT SelV Selenium binding proteins Selenbp1 Fabp1 Pstk Cystathionine g-lyase Scly UGA eEFSec Sla Rpl30 SBP2 Hydrogen selenide Selenophosphate MethylSelenol MeSeH SeC SeMet TXNRD3 TXNRD2 TXNRD1 Selenate Selenite Sephs1 Sephs2 Sars2 Sars SBP2 eEFSec Secp43 Name: Selenium Metabolism and Selenoproteins License: CC BY 2.0 Last Modified: 10/16/2013 Organism: Homo sapiens


  • Comments belonging to specific genes on the Selenoprotein pathway
    • TRXND3 gene: Although the geneID is correct, the sequence of this gene was guessed by analogy.
    • Cystathionine gamma-lyase is the mammalian form of bacterial methionine gamma-lyase
    • A selenoprotein database exists at:

Quality Tags

Ontology Terms



  1. Papp LV, Lu J, Holmgren A, Khanna KK; ''From selenium to selenoproteins: synthesis, identity, and their role in human health.''; Antioxid Redox Signal, 2007 PubMed
  2. Thompson HJ, Clement IP; ''''; , PubMed
  3. Small-Howard AL, Berry MJ; ''Unique features of selenocysteine incorporation function within the context of general eukaryotic translational processes.''; Biochem Soc Trans, 2005 PubMed
  4. Boosalis MG; ''The role of selenium in chronic disease.''; Nutr Clin Pract, 2008 PubMed
  5. Wang H, Zhang J, Yu H; ''Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on selenoenzymes: comparison with selenomethionine in mice.''; Free Radic Biol Med, 2007 PubMed
  6. Commandeur JN, Andreadou I, Rooseboom M, Out M, de Leur LJ, Groot E, Vermeulen NP; ''''; , PubMed
  7. Gromer S, Eubel JK, Lee BL, Jacob J; ''Human selenoproteins at a glance.''; Cell Mol Life Sci, 2005 PubMed
  8. Soda K, Oikawa T, Esaki N; ''Vitamin B6 enzymes participating in selenium amino acid metabolism.''; Biofactors, 1999 PubMed
  9. Ip C, Hayes C; ''Tissue selenium levels in selenium-supplemented rats and their relevance in mammary cancer protection.''; Carcinogenesis, 1989 PubMed
  10. Xia Y, Hill KE, Byrne DW, Xu J, Burk RF; ''Effectiveness of selenium supplements in a low-selenium area of China.''; Am J Clin Nutr, 2005 PubMed
  11. Xu XM, Carlson BA, Mix H, Zhang Y, Saira K, Glass RS, Berry MJ, Gladyshev VN, Hatfield DL; ''Biosynthesis of selenocysteine on its tRNA in eukaryotes.''; PLoS Biol, 2007 PubMed
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71888view 02:47, 22 October 2013Mkutmonchanged FOS from Unknown to GeneProduct
71250view 13:37, 16 October 2013MaintBotAutomated update of data sources
68932view 10:34, 8 July 2013MaintBotUpdated to 2013 gpml schema
68048view 05:08, 29 June 2013EgonwAdded missing metabolite identifiers.
61686view 15:01, 16 April 2013MaintBotupdated swissprot data source to uniprot/trembl
59121view 15:28, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
46518view 21:00, 9 February 2012Strandadded selenite identifier
46517view 20:58, 9 February 2012Strandcorrected RefSeq identifier
46516view 20:57, 9 February 2012Strandcorrect RefSeq identifiers
46500view 16:22, 6 February 2012AlexanderPicofixed a refseq id
45019view 11:38, 6 October 2011ThomasOntology Term : 'selenoamino acid metabolic pathway' added !
41081view 16:20, 1 March 2011MaintBotRemoved redundant pathway information and comments
39764view 00:43, 17 January 2011AlexanderPicomore complete title
38852view 10:58, 24 September 2010Khanspers
38755view 15:36, 23 September 2010KhanspersChanged nucleus
37163view 12:21, 19 May 2010EveloAdded backpages for selenite and hydrogen selenide
37162view 12:12, 19 May 2010EveloCosmetic
35187view 08:05, 11 February 2010EveloCosmetic changes and some backpages
35168view 07:51, 11 February 2010EveloPeriodical save, work in progress
35155view 07:25, 11 February 2010EveloPeriodical save, work in progress
35145view 07:15, 11 February 2010EveloPeriodical save, work in progress
35135view 07:04, 11 February 2010EveloPeriodical save, work in progress
32383view 09:56, 15 August 2009MaintBotFixed text labels
32026view 06:24, 14 August 2009MaintBotFixed group labels
30051view 15:51, 29 June 2009Andraconnect line
30050view 15:46, 29 June 2009AndraAdded references
29723view 14:41, 1 June 2009Khanspersupdated Ensembl refs
28969view 02:56, 19 March 2009SusanChanged NFKB-p65 ID
28934view 04:26, 16 March 2009EveloPeriodical save, work in progress
28784view 06:14, 6 March 2009EveloModified description
28781view 06:02, 6 March 2009EveloAdded two gene ID's
28131view 12:45, 27 January 2009KhanspersRemoved species code from name
20735view 04:29, 14 November 2008MaintBot[[Pathway:Homo sapiens:Selenoproteins]] moved to [[Pathway:WP28]]: Moved to stable identifier
19220view 07:57, 24 September 2008SusanGraphical adaptation
15890view 07:12, 6 June 2008EgoyenecheaPeriodical save, work in progress
14945view 09:09, 24 May 2008MartijnVanIersellinked up
14943view 08:58, 24 May 2008MartijnVanIerselCreated metabolites
8382view 06:46, 7 January 2008MaintBot[[Pathway:Human:Selenoproteins]] moved to [[Pathway:Homo sapiens:Selenoproteins]]: Renaming species
7808view 09:19, 18 December 2007MaintBotfixed category names
7496view 06:10, 4 November 2007Thomastransfered literature references to GPML
7387view 05:42, 4 November 2007MaintBotAdded categories to GPML
7189view 05:31, 4 November 2007MaintBotAdded description to GPML
7104view 06:08, 10 October 2007Susantest
7001view 05:09, 9 August 2007SusanChanged gamma lyase
6970view 01:57, 30 July 2007137.120.89.28Added/changed transcription factors
6967view 01:13, 30 July 2007Thomas[[GPML:Human:Hs Selenoproteins]] moved to [[GPML:Human:Selenoproteins]]: removed Hs prefix (old GenMAPP naming convention)
6920view 02:08, 24 July 2007SusanNew pathway
6919view 02:02, 24 July 2007SusanNew pathway
6916view 02:00, 24 July 2007SusanNew pathway

External references


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NameTypeDatabase referenceComment
CREMGeneProductQ03060 (Uniprot-TrEMBL)
Cystathionine g-lyaseGeneProductNP_001893 (RefSeq)
DIO1GeneProduct1733 (Entrez Gene)
DIO2GeneProduct1734 (Entrez Gene)
DIO3GeneProduct1735 (Entrez Gene)
FOSGeneProductENSG00000170345 (Ensembl)
Fabp1GeneProduct2168 (Entrez Gene)
GPX1GeneProduct2876 (Entrez Gene)
GPX2GeneProduct2877 (Entrez Gene)
GPX3GeneProduct2878 (Entrez Gene)
GPX4GeneProduct2879 (Entrez Gene)
GPX6GeneProduct257202 (Entrez Gene)
Hydrogen selenideMetaboliteHMDB11110 (HMDB)
JUNGeneProductENSG00000177606 (Ensembl)
MethylSelenol MeSeHMetabolite389633 (Chemspider)
NFKB-p105GeneProduct4790 (Entrez Gene)
NFKB-p65GeneProduct5970 (Entrez Gene)
Nfe2l2GeneProductNM_006164 (RefSeq)
Pouf2f1GeneProductP14859 (Uniprot-TrEMBL)
PstkGeneProductQ8IV42 (Uniprot-TrEMBL)
Rpl30GeneProduct6156 (Entrez Gene)
SBP2GeneProductQ96T21 (Uniprot-TrEMBL)
SEPN1GeneProduct57190 (Entrez Gene)
SEPP1GeneProduct6414 (Entrez Gene)
SPS2GeneProduct22928 (Entrez Gene)
Sars2GeneProduct54938 (Entrez Gene)
SarsGeneProductP49591 (Uniprot-TrEMBL)
SclyGeneProduct51540 (Entrez Gene)
SeCMetaboliteHMDB03288 (HMDB)
SeMetMetaboliteHMDB03966 (HMDB)
Secp43GeneProduct54952 (Entrez Gene)
SelHGeneProduct280636 (Entrez Gene)
SelIGeneProduct85465 (Entrez Gene)
SelKGeneProduct58515 (Entrez Gene)
SelMGeneProduct140606 (Entrez Gene)
SelOGeneProduct83642 (Entrez Gene)
SelSGeneProduct55829 (Entrez Gene)
SelTGeneProduct51714 (Entrez Gene)
SelVGeneProduct348303 (Entrez Gene)
SelenateMetabolite24657 (Chemspider)
Selenbp1GeneProduct8991 (Entrez Gene)
SeleniteMetaboliteHMDB11119 (HMDB)
SelenophosphateMetaboliteHMDB06407 (HMDB)
Sep15GeneProductO60613 (Uniprot-TrEMBL)
SepWGeneProduct6415 (Entrez Gene)
SepX1GeneProduct51734 (Entrez Gene)
Sephs1GeneProductP49903 (Uniprot-TrEMBL)
Sephs2GeneProductNP_036380 (RefSeq)
SlaGeneProduct51091 (Entrez Gene)
Sp1GeneProductNP_612482 (RefSeq)
Sp3GeneProduct6670 (Entrez Gene)
TXNRD1GeneProduct7296 (Entrez Gene)
TXNRD2GeneProduct10587 (Entrez Gene)
TXNRD3GeneProduct114112 (Entrez Gene)
eEFSecGeneProduct60678 (Entrez Gene)

Annotated Interactions

<cite>No annotated interactions</cite>