Nanoparticle-mediated activation of receptor signaling (Homo sapiens)

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α β NP-induced extracellular ROS production Receptor-mediated NP uptake Integrin Autocrine loop EGFR HRAS Apoptosis Fibronectin Collagen Amphiregulin ROS NRAS KRAS RAF MAP2K1 MAP2K2 MAPK1 JNK1 JNK2 JNK3 MAPK12 MAPK13 MAPK14 MAPK11 Talin Paxillin Src FAK Sos Grb PI3K AKT Proliferation Inflammation Migration Angiogenesis Differentiation ROS Endocytosis of NP Name: Nanoparticle-mediated activation of receptor signaling Organism: Homo sapiens


Description

Nanoparticle-mediated activation of receptor signaling. Several NP formulations were shown to interact with cellular receptors such as the EGFR and integrins, inducing cellular phenotypes such as proliferation, apoptosis, differentiation, and migration. In lung epithelial cells, NPs interact with both EGFR and integrins, leading to cell proliferation via activation of PI3K and AKT. NPs were shown to activate the EGFR, leading in parallel to apoptosis and proliferation, and oncogenic Ras mutations might influence these effects. Interestingly, while integrin-mediated activation of ERK was instrumental for proliferation, apoptosis was mediated via activation of JNK. In addition, NPs (PM2.5) are able to bind the EGFR to activate the MAPK signaling cascade. Activation of ERK leads to the expression and secretion of the epidermal growth factor amphiregulin, thus forming an autocrine loop, which might be instrumental for sustained inflammatory responses. Nanoparticles are depicted as red circles.

Quality Tags

Ontology Terms

<OntologyTags></OntologyTags>

Bibliography

  1. Rauch J, Kolch W, Laurent S, Mahmoudi M; ''Big signals from small particles: regulation of cell signaling pathways by nanoparticles.''; Chem Rev, 2013 PubMed

History

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RevisionActionTimeUserComment
95473view 01:43, 16 December 2017EgonwOh, there were two nodes :(
95472view 01:42, 16 December 2017EgonwReplace a Wikipedia ID with the matching Wikidata ID (with more mappings).
92317view 01:50, 20 May 2017EgonwOntology Term : 'nanomaterial response pathway' added !
87898view 05:53, 25 July 2016ElisaOntology Term : 'signaling pathway' added !
74251view 01:45, 11 April 2014ElisaUsing label type for text elements
74250view 01:40, 11 April 2014ElisaUsing label type for text elements
74187view 04:00, 3 April 2014Bart SmeetsModified title
74186view 04:00, 3 April 2014Bart SmeetsModified description
74185view 03:56, 3 April 2014Bart SmeetsModified description
74184view 03:55, 3 April 2014Bart SmeetsModified description
74183view 03:55, 3 April 2014Bart SmeetsNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKTProteinQ9Y243 (Uniprot-TrEMBL)
AmphiregulinProteinP15514 (Uniprot-TrEMBL)
AngiogenesisAngiogenesis (Wikipedia)
ApoptosisApoptosis (Wikipedia)
CollagenProteinP02452 (Uniprot-TrEMBL)
DifferentiationCellular differentiation (Wikipedia)
EGFRProteinP00533 (Uniprot-TrEMBL)
FAKProteinQ05397 (Uniprot-TrEMBL)
FibronectinProteinP02751 (Uniprot-TrEMBL)
GrbProteinP62993 (Uniprot-TrEMBL)
HRASProteinP01112 (Uniprot-TrEMBL)
InflammationInflammation (Wikipedia)
JNK1ProteinP45983 (Uniprot-TrEMBL)
JNK2ProteinP45984 (Uniprot-TrEMBL)
JNK3ProteinP53779 (Uniprot-TrEMBL)
KRASProteinP01116 (Uniprot-TrEMBL)
MAP2K1ProteinQ02750 (Uniprot-TrEMBL)
MAP2K2ProteinP36507 (Uniprot-TrEMBL)
MAPK11ProteinQ15759 (Uniprot-TrEMBL)
MAPK12ProteinP53778 (Uniprot-TrEMBL)
MAPK13ProteinO15264 (Uniprot-TrEMBL)
MAPK14 ProteinQ16539 (Uniprot-TrEMBL)
MAPK1ProteinP28482 (Uniprot-TrEMBL)
MigrationCell migration (Wikipedia)
NRASProteinP01111 (Uniprot-TrEMBL)
PI3KProteinO00329 (Uniprot-TrEMBL)
PaxillinProteinP49023 (Uniprot-TrEMBL)
ProliferationCell proliferation (Wikipedia)
RAFProteinP04049 (Uniprot-TrEMBL)
ROSQ424361 (Wikidata)
SosProteinQ07889 (Uniprot-TrEMBL)
SrcProteinP12931 (Uniprot-TrEMBL)
TalinProteinQ9Y490 (Uniprot-TrEMBL)
αProteinP56199 (Uniprot-TrEMBL)
βProteinP05556 (Uniprot-TrEMBL)

Annotated Interactions

<cite>No annotated interactions</cite>