Nifedipine Activity (Homo sapiens)

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Cholesterol phosphorylation Nifedipine phosphorylation cell growth inhibition phosphorylation 77 77 77 77 77 Angiogenesis 79 79 79 79, 82, 84 79 79 ROS 81 Antioxidative Vasodilatation Antithrombotic Antiprolerative Antiartherosclerosis Rapid degration by daylight Nitrosonifedipine 83 Lactam derivate 83 in vivo Fe uptake Zn uptake 83 79 81 81 81 81, 88 81 86 86 86 Na balance Serum induced DNA synthesis Delay G0/G1 --> S-phase Ca uptake 88 88 METABOLISM liver and small intestine CYP3A4 CYP2C11 MAP2K1 MAPK1 PTK2B PCNA PKC VEGF SOD Cholesterol hydrolase Cholesterol esterase NO BDKRB2 KDR/FLK1 Ca-channel NADPH oxidase Name: Nifedipine Activity License: CC BY 2.0 Organism: Homo sapiens


Nifedipine (brand names Adalat, Nifediac, Cordipin, Nifedical, and Procardia) is a dihydropyridine calcium channel blocker. Its main uses are as an antianginal (especially in Prinzmetal's angina) and antihypertensive, although a large number of other indications have recently been found for this agent, such as Raynaud's phenomenon, premature labor, and painful spasms of the esophagus in cancer and tetanus patients. It is also commonly used for the small subset of pulmonary hypertension patients whose symptoms respond to calcium channel blockers. Source: Wikipedia (wikipedia:Nifedipine)

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Ontology Terms



  1. Hirata A, Igarashi M, Yamaguchi H, Suwabe A, Daimon M, Kato T, Tominaga M; ''Nifedipine suppresses neointimal thickening by its inhibitory effect on vascular smooth muscle cell growth via a MEK-ERK pathway coupling with Pyk2.''; Br J Pharmacol, 2000 PubMed


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88585view 12:25, 11 August 2016Mkutmonfix unconnected lines
75227view 12:24, 12 May 2014Khansperslayout, xrefs, connections
74419view 05:42, 18 April 2014EgonwConverted two labels into metabolite DataNodes with an identifier.
71991view 04:18, 24 October 2013MkutmonChanged Unknown -> GeneProduct for all annotated data nodes
68905view 10:30, 8 July 2013MaintBotUpdated to 2013 gpml schema
67508view 04:18, 26 June 2013DdiglesOntology Term : 'nifedipine drug pathway' added !
45358view 13:43, 7 October 2011KhanspersModified description
45357view 13:42, 7 October 2011KhanspersModified description
45356view 13:41, 7 October 2011KhanspersOntology Term : 'heart disease' added !
45355view 13:40, 7 October 2011KhanspersOntology Term : 'hypertension' added !
41054view 16:17, 1 March 2011MaintBotRemoved redundant pathway information and comments
39776view 14:35, 17 January 2011AlexanderPicomore complete title
38868view 11:23, 24 September 2010KhanspersChanged line types
34583view 15:23, 21 December 2009KhanspersModified categories
34447view 11:20, 10 December 2009MaintBotAutomatic update of empty xrefs
26597view 12:11, 10 December 2008AlexanderPicoupdate
26595view 12:10, 10 December 2008AlexanderPicoadded connectors, database refs and literature ref
26593view 12:05, 10 December 2008AlexanderPicoPeriodical save, work in progress
21223view 04:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:test1234]] moved to [[Pathway:WP259]]: Moved to stable identifier
20471view 03:39, 7 November 2008RobatwikiNew pathway

External references


View all...
NameTypeDatabase referenceComment
BDKRB2GeneProduct624 (Entrez Gene)
CYP3A4GeneProduct1576 (Entrez Gene)
Cholesterol esterase
Cholesterol hydrolase
CholesterolMetaboliteCHEBI:16113 (ChEBI)
KDR/FLK1GeneProduct3791 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
NADPH oxidaseGeneProduct
NOMetaboliteHMDB03378 (HMDB)
NifedipineMetaboliteCHEBI:7565 (ChEBI)
PCNAGeneProduct5111 (Entrez Gene)
PKCGeneProduct50818 (Entrez Gene)
PTK2BGeneProduct2185 (Entrez Gene)
SODGeneProduct6647 (Entrez Gene)
VEGFProteinVEGF (Uniprot-TrEMBL)

Annotated Interactions

<cite>No annotated interactions</cite>