Polycystic Kidney Disease Pathway (Homo sapiens)

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TNF AMPK cyclinD IKK2 MTOR AMP Protein Synthesis Dvl Nucleus Ca2+ cAMP EGF IGF1 VEGF Increased in PKD Decreased in PKD PC1 PC2 SOC PC1 PC2 PC2 mTOR inhibitors RHEB TSC2 TSC1 RSK ERK MEK CDK inhibitors MEK inh GSK3beta Metformin Ca2+ Ca2+ Ca2+ PDE Ac-VI PKA TNFalpha TNF anatagonist BRAF Ras SRC Src inh PKA IP3 Triptolide PLCgamma TKIs PKA Cl- CTFR inh R Gq R Gi V2R Gs Somatostatin Vasopressin V2RA Frizzled Wnt sFRP4 AMP ADP ATP ATPase LKB1 Na+ K+ phos JUN MYC ATPase Na+ K+ Na+ NKCC1 K+ KCa3.1 KCa3.1 inh beta-Catenin Proteasome PC1 PC1 PC2 ATP Name: Polycystic Kidney Disease Pathway Organism: Homo sapiens


Description

A putative PKD pathway proposed in Torres 2009 (Figure 2), showing up or down regulated genes.

Quality Tags

Ontology Terms

<OntologyTags></OntologyTags>

Bibliography

  1. Torres VE, Harris PC; ''Autosomal dominant polycystic kidney disease: the last 3 years.''; Kidney Int, 2009 PubMed

History

View all...
RevisionActionTimeUserComment
97490view 06:49, 23 May 2018Fehrhartadded annotations
88333view 08:54, 1 August 2016FehrhartOntology Term : 'kidney disease pathway' added !
84489view 16:15, 25 February 2016KhanspersQuick edit to datanode annotation or property
79790view 09:02, 16 April 2015Mkutmonfixed unconnected line
78508view 03:29, 7 January 2015MaintBotadded missing graphIds
78125view 09:17, 4 December 2014Mkutmonadded more xrefs and some layout changes
78124view 08:48, 4 December 2014Mkutmonadded some xrefs
78123view 08:23, 4 December 2014Mkutmonremoved fill color since it is not ideal for visualization
74333view 14:14, 12 April 2014EgonwModified description
71048view 11:21, 25 September 2013EgonwAdded several identifiers.
71047view 10:19, 25 September 2013EgonwCompleted entering all entities.
71046view 06:06, 25 September 2013EgonwAdded identifiers for two PKD genes.
71045view 04:47, 25 September 2013EgonwMore pathway content.
71044view 04:16, 25 September 2013EgonwMore entities. Prob. 20% done now, excl identifiers.
71043view 03:49, 25 September 2013EgonwModified description
71042view 03:47, 25 September 2013EgonwNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
beta-Catenin
ADPMetaboliteCHEBI:16761 (ChEBI)
AMP MetaboliteCHEBI:16027 (ChEBI)
AMPMetaboliteCHEBI:16027 (ChEBI)
AMPKGeneProduct
ATPMetaboliteCHEBI:15422 (ChEBI)
ATPase
Ac-VI
BRAFGeneProductENSG00000157764 (Ensembl)
CDK inhibitorsMetabolite
CTFR inhMetabolite
Ca2+MetaboliteCHEBI:29108 (ChEBI)
Cl-Metabolite
Decreased in PKD
Dvl
EGFGeneProductENSG00000138798 (Ensembl)
ERKGeneProduct
Frizzled
GSK3betaGeneProduct
Gi
Gq
Gs
IGF1GeneProductENSG00000017427 (Ensembl)
IKK2GeneProductENSG00000104365 (Ensembl)
IP3MetaboliteCHEBI:16595 (ChEBI)
Increased in PKD
JUNGeneProductENSG00000177606 (Ensembl)
K+Metabolite791 (Chemspider)
KCa3.1 inhMetabolite
KCa3.1GeneProductENSG00000104783 (Ensembl)
LKB1GeneProductENSG00000118046 (Ensembl)
MEK inhMetabolite
MEKGeneProductENSG00000095015 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
MYCGeneProductENSG00000136997 (Ensembl)
MetforminMetabolite
NKCC1
Na+Metabolite923 (PubChem-compound)
Na+MetaboliteCHEBI:29101 (ChEBI)
Nucleus
PC1GeneProductENSG00000008710 (Ensembl)Also known as PKD1.
PC2GeneProductENSG00000118762 (Ensembl)Also known as PKD2.
PDEGeneProduct
PKA
PLCgammaGeneProduct
ProteasomePathway
Protein SynthesisPathway
R
RHEBGeneProductENSG00000106615 (Ensembl)
RSKGeneProduct
RasGeneProduct
SOCGeneProduct
SRCGeneProductENSG00000197122 (Ensembl)
SomatostatinMetaboliteHMDB13072 (HMDB)
Src inhMetabolite
TKIsMetabolite
TNF anatagonistMetabolite
TNFGeneProductENSG00000232810 (Ensembl)
TNFalphaGeneProductENSG00000204490 (Ensembl)
TSC1GeneProductENSG00000165699 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)
Triptolide
V2R
V2RA
VEGFGeneProduct
VasopressinMetaboliteHMDB01980 (HMDB)
Wnt
cAMP MetaboliteHMDB00058 (HMDB)
cyclinDGeneProductENSG00000110092 (Ensembl)
mTOR inhibitorsMetabolite
phos
sFRP4

Annotated Interactions

<cite>No annotated interactions</cite>