Apoptosis (Homo sapiens)

From WikiPathways
Jump to: navigation, search
Casp Activator of Cell Death p Fas Ligand p Apoptosis DNA Fragmentation Degradation NFKBIA NFKBIB NFKBIE b b e Mitochondrion IGF1R signaling pathway b Interferon regulatory factors IRF1 IRF2 IRF6 IRF5 IRF3 IRF7 IRF4 e p53 Related TP73 TP63 Inhibitor of Cell Death MIR29A PMAIP1 BBC3 BOK MIR29B1 MIR29B2 CASP9 MDM2 BAK1 TRAF3 TRAF1 TRAF2 NFKB1 RELA NFKBIB NFKBIE NFKBIA FAS BIRC2 BIRC3 DIABLO AKT1 GZMB TNFRSF21 TNFRSF1B TNFRSF25 TRADD TNFRSF10B TNFRSF1A BAD CASP1 RIPK1 TRADD FADD LTA CASP4 CASP3 PRF1 TNFRSF1A CRADD IGF1R CHUK IKBKB IKBKG BAX APAF1 CASP10 BID MAPK10 DFFA CYCS CASP2 HRK CASP11 CASP7 MYC TNF IGF2 IGF1 CFLAR BCL2L2 BCL2 BCL2L1 MCL1 PIK3R1 BIRC5 BIRC4 JUN BNIP3L DFFB RELA NFKB1 TP53 MAP2K4 RIPK1 CDKN2A CASP8 BAD FASLG TNFSF10 HELLS CASP6 BCL2L11 MAP3K1 Name: Apoptosis License: CC BY 2.0 Last Modified: 10/17/2013 Organism: Homo sapiens


Apoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and membrane blebbing characterize apoptosis in general. Mitochondria remain morphologically unchanged. In 1972 Kerr et al introduced the concept of apoptosis as a distinct form of "cell-death", and the mechanisms of various apoptotic pathways are still being revealed today.

Quality Tags

Ontology Terms



  1. Park SY, Lee JH, Ha M, Nam JW, Kim VN; ''miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42.''; Nat Struct Mol Biol, 2009 PubMed
  2. Bose I, Ghosh B; ''The p53-MDM2 network: from oscillations to apoptosis.''; J Biosci, 2007 PubMed
  3. Lakin ND, Jackson SP; ''Regulation of p53 in response to DNA damage.''; Oncogene, 1999 PubMed
  4. Xiong Y, Fang JH, Yun JP, Yang J, Zhang Y, Jia WH, Zhuang SM; ''Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma.''; Hepatology, 2010 PubMed
  5. Mott JL, Kobayashi S, Bronk SF, Gores GJ; ''mir-29 regulates Mcl-1 protein expression and apoptosis.''; Oncogene, 2007 PubMed


View all...
96952view 10:34, 22 April 2018AlexanderPicoReverted to version '13:10, 7 April 2018' by AlexanderPico
96951view 04:45, 22 April 2018AnamModified title
96789view 13:10, 7 April 2018AlexanderPicoupdated mir ensembl IDs
95107view 07:10, 16 November 2017EgonwFixed nested grouping.
93003view 11:31, 21 July 2017KhanspersReverted to version '09:18, 18 August 2016' by Khanspers
92879view 01:45, 13 July 2017JosipMadunic
88977view 02:18, 18 August 2016MirellaKalafatiOntology Term : 'regulatory pathway' added !
88976view 02:18, 18 August 2016MirellaKalafatiOntology Term : 'PW:0000002' removed !
88896view 00:47, 17 August 2016MirellaKalafatiOntology Term : 'classic metabolic pathway' added !
88580view 12:14, 11 August 2016Mkutmonfix unconnected lines
84652view 15:25, 10 March 2016KhanspersQuick edit to datanode annotation or property
80450view 11:47, 23 June 2015KhanspersAdded mir29a targeting of PIK3R1
80153view 12:10, 14 May 2015KhanspersAdded mir29b targeting and associated lit ref, layout changes to improve readability
79789view 08:57, 16 April 2015Mkutmonfixed unconnected line
78808view 02:26, 31 January 2015EgonwConnected dots.
72110view 15:20, 24 October 2013AlexanderPicoCYCS alone encodes for Cytochrome C in humans; and SCAF11 is alias for CASP11
71386view 11:41, 17 October 2013MaintBotAutomated update of data sources
70880view 14:57, 12 September 2013MaintBotModified description
70863view 06:55, 12 September 2013NunoModified description
70862view 06:53, 12 September 2013NunoModified description
70861view 06:51, 12 September 2013NunoModified description
63143view 12:18, 8 May 2013MaintBotUpdating GPML version
56066view 22:32, 31 December 2012AriuttaReverted to version '23:43, 1 March 2011' by Ariutta
56065view 22:28, 31 December 2012AriuttaPeriodical save, work in progress
41184view 16:43, 1 March 2011MaintBotRemoved redundant pathway information and comments
39385view 15:17, 19 November 2010AlexanderPicoupdated mito
38946view 16:11, 24 September 2010Khanspers
38801view 00:21, 24 September 2010Jildaumitochondrion
35092view 05:54, 11 February 2010MartijnVanIersellit. ref. added
35090view 05:40, 11 February 2010MartijnVanIerselAdded review on P53
34958view 15:10, 8 February 2010KhanspersAdded xref for TP63
32014view 06:21, 14 August 2009MaintBotFixed group labels
29955view 12:09, 15 June 2009GillespmModified description
22525view 05:51, 14 November 2008MartijnVanIerselChanged title back to original
21213view 04:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:Apoptosis]] moved to [[Pathway:WP254]]: Moved to stable identifier
15853view 00:57, 6 June 2008AngelikaModified description
14128view 07:27, 21 May 2008SusanAdded connections and created groups
13018view 04:06, 17 May 2008MaintBotSticky edges patch by Sjoerd
11590view 00:36, 16 April 2008ThomasReverted edits by [[Special:Contributions/AlexanderPico|AlexanderPico]] ([[User_talk:AlexanderPico|Talk]]); changed back to last version by [[User:MaintBot|MaintBot]]
11588view 16:54, 15 April 2008AlexanderPicoModified categories
7908view 06:46, 7 January 2008MaintBot[[Pathway:Human:Apoptosis]] moved to [[Pathway:Homo sapiens:Apoptosis]]: Renaming species
7579view 09:01, 18 December 2007MaintBotfixed category names
7198view 05:33, 4 November 2007MaintBotAdded categories to GPML
19383view 15:17, 22 May 2007B.Lawlorgpml file for [[Human:Apoptosis]]
6295view 15:17, 22 May 2007A.C.Zambongpml file for [[Human:Apoptosis]]

External references


View all...
NameTypeDatabase referenceComment
AKT1GeneProduct207 (Entrez Gene)
APAF1GeneProduct317 (Entrez Gene)
BADGeneProduct572 (Entrez Gene)
BAK1GeneProduct578 (Entrez Gene)
BAXGeneProduct581 (Entrez Gene)
BBC3GeneProduct27113 (Entrez Gene)
BCL2GeneProduct596 (Entrez Gene)
BCL2L11GeneProduct10018 (Entrez Gene)
BCL2L1GeneProduct598 (Entrez Gene)
BCL2L2GeneProduct599 (Entrez Gene)
BIDGeneProduct637 (Entrez Gene)
BIRC2GeneProduct329 (Entrez Gene)
BIRC3GeneProduct330 (Entrez Gene)
BIRC4GeneProduct331 (Entrez Gene)
BIRC5GeneProduct332 (Entrez Gene)
BNIP3LGeneProduct665 (Entrez Gene)
BOKGeneProduct666 (Entrez Gene)
CASP10GeneProduct843 (Entrez Gene)
CASP11GeneProduct9169 (Entrez Gene)
CASP1GeneProduct834 (Entrez Gene)
CASP2GeneProduct835 (Entrez Gene)
CASP3GeneProduct836 (Entrez Gene)
CASP4GeneProduct837 (Entrez Gene)
CASP6GeneProduct839 (Entrez Gene)
CASP7GeneProduct840 (Entrez Gene)
CASP8GeneProduct841 (Entrez Gene)
CASP9GeneProduct842 (Entrez Gene)
CDKN2AGeneProduct1029 (Entrez Gene)
CFLARGeneProduct8837 (Entrez Gene)
CHUKGeneProduct1147 (Entrez Gene)
CRADDGeneProduct8738 (Entrez Gene)
CYCSGeneProduct54205 (Entrez Gene)
DFFAGeneProduct1676 (Entrez Gene)
DFFBGeneProduct1677 (Entrez Gene)
DIABLOGeneProduct56616 (Entrez Gene)
FADDGeneProduct8772 (Entrez Gene)
FASGeneProduct355 (Entrez Gene)
FASLGGeneProduct356 (Entrez Gene)
GZMBGeneProduct3002 (Entrez Gene)
HELLSGeneProduct3070 (Entrez Gene)
HRKGeneProduct8739 (Entrez Gene)
IGF1GeneProduct3479 (Entrez Gene)
IGF1RGeneProduct3480 (Entrez Gene)
IGF2GeneProduct3481 (Entrez Gene)
IKBKBGeneProduct3551 (Entrez Gene)
IKBKGGeneProduct8517 (Entrez Gene)
IRF1GeneProduct3659 (Entrez Gene)
IRF2GeneProduct3660 (Entrez Gene)
IRF3GeneProduct3661 (Entrez Gene)
IRF4GeneProduct3662 (Entrez Gene)
IRF5GeneProduct3663 (Entrez Gene)
IRF6GeneProduct3664 (Entrez Gene)
IRF7GeneProduct3665 (Entrez Gene)
JUNGeneProduct3725 (Entrez Gene)
LTAGeneProduct4049 (Entrez Gene)
MAP2K4GeneProduct6416 (Entrez Gene)
MAP3K1GeneProduct4214 (Entrez Gene)
MAPK10GeneProduct5602 (Entrez Gene)
MCL1GeneProduct4170 (Entrez Gene)
MDM2GeneProduct4193 (Entrez Gene)
MIR29AGeneProductENSG00000284032 (Ensembl)
MIR29B1GeneProductENSG00000283797 (Ensembl)
MIR29B2GeneProductENSG00000284203 (Ensembl)
MYCGeneProduct4609 (Entrez Gene)
NFKB1GeneProduct4790 (Entrez Gene)
NFKBIAGeneProduct4792 (Entrez Gene)
NFKBIBGeneProduct4793 (Entrez Gene)
NFKBIEGeneProduct4794 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PMAIP1GeneProduct5366 (Entrez Gene)
PRF1GeneProduct5551 (Entrez Gene)
RELAGeneProduct5970 (Entrez Gene)
RIPK1GeneProduct8737 (Entrez Gene)
TNFGeneProduct7124 (Entrez Gene)
TNFRSF10BGeneProduct8795 (Entrez Gene)
TNFRSF1AGeneProduct7132 (Entrez Gene)
TNFRSF1BGeneProduct7133 (Entrez Gene)
TNFRSF21GeneProduct27242 (Entrez Gene)
TNFRSF25GeneProduct8718 (Entrez Gene)
TNFSF10GeneProduct8743 (Entrez Gene)
TP53GeneProduct7157 (Entrez Gene)
TP63GeneProduct8626 (Entrez Gene)
TP73GeneProduct7161 (Entrez Gene)
TRADDGeneProduct8717 (Entrez Gene)
TRAF1GeneProduct7185 (Entrez Gene)
TRAF2GeneProduct7186 (Entrez Gene)
TRAF3GeneProduct7187 (Entrez Gene)

Annotated Interactions

<cite>No annotated interactions</cite>