Nanomaterial induced apoptosis (Homo sapiens)

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Lysosomal impairment Nanohorn TiO2 NP Polystyrene NP PAMAM BCL-2 DNA Ca2+ Capthepsins UPR IAPs CASP9 tBID CASP8 FLIP FADD FAS FASLG APAF-1 Cyt C Lutic granule APOPTOSIS Ag NP Au NP CASP7 CASP6 CASP3 BAK BAX AIF EndoG SMAC/DIABLO HTRA2/OMI Perforin Name: Nanomaterial induced apoptosis Organism: Homo sapiens


Apotosis caused by nanomaterials, such as single-walled carbon nanohorns, titanium oxide, and polystyrene nanoparticles, may be induced through lysosomal impairment. For example, PAMAMs have been found to cause mitochondrial membrane destabilization, and silver and gold nanoparticles are reported to induce ER stress, which may lead to cytochrome c release from mitochondria.

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Ontology Terms



  1. Tsai YY, Huang YH, Chao YL, Hu KY, Chin LT, Chou SH, Hour AL, Yao YD, Tu CS, Liang YJ, Tsai CY, Wu HY, Tan SW, Chen HM; ''Identification of the nanogold particle-induced endoplasmic reticulum stress by omic techniques and systems biology analysis.''; ACS Nano, 2011 PubMed
  2. Zhang R, Piao MJ, Kim KC, Kim AD, Choi JY, Choi J, Hyun JW; ''Endoplasmic reticulum stress signaling is involved in silver nanoparticles-induced apoptosis.''; Int J Biochem Cell Biol, 2012 PubMed
  3. Andón FT, Fadeel B; ''Programmed Cell Death: Molecular Mechanisms and Implications for Safety Assessment of Nanomaterials.''; Acc Chem Res, 2012 PubMed
  4. Lee JH, Cha KE, Kim MS, Hong HW, Chung DJ, Ryu G, Myung H; ''Nanosized polyamidoamine (PAMAM) dendrimer-induced apoptosis mediated by mitochondrial dysfunction.''; Toxicol Lett, 2009 PubMed
  5. Hussain S, Thomassen LC, Ferecatu I, Borot MC, Andreau K, Martens JA, Fleury J, Baeza-Squiban A, Marano F, Boland S; ''Carbon black and titanium dioxide nanoparticles elicit distinct apoptotic pathways in bronchial epithelial cells.''; Part Fibre Toxicol, 2010 PubMed
  6. Xia T, Kovochich M, Liong M, Zink JI, Nel AE; ''Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways.''; ACS Nano, 2008 PubMed
  7. Tahara Y, Nakamura M, Yang M, Zhang M, Iijima S, Yudasaka M; ''Lysosomal membrane destabilization induced by high accumulation of single-walled carbon nanohorns in murine macrophage RAW 264.7.''; Biomaterials, 2012 PubMed
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97098view 22:35, 27 April 2018EgonwUndo revision 97097 by [[Special:Contributions/Mechebek|Mechebek]] ([[User talk:Mechebek|Talk]])
97097view 13:19, 27 April 2018WpblockedModified title
92314view 01:49, 20 May 2017EgonwOntology Term : 'nanomaterial response pathway' added !
89231view 04:41, 24 August 2016Torresandonfix author name
88584view 12:24, 11 August 2016Mkutmonfix unconnected lines
86008view 01:38, 24 June 2016FehrhartAdded some missing annotatins
85993view 02:45, 23 June 2016FehrhartConnected lines
78557view 03:31, 7 January 2015MaintBotadded missing graphIds
74150view 04:38, 1 April 2014Bart SmeetsFixed some names
74141view 03:01, 1 April 2014Bart SmeetsExpanded description for nanomaterials, added some literature references
74140view 02:57, 1 April 2014Bart Smeets
74139view 02:07, 1 April 2014Bart SmeetsSpecify description
73824view 07:59, 25 February 2014Bart Smeetsfixed some gene names to original name
73822view 07:45, 25 February 2014Bart Smeetsremoved underscores UPR
73821view 07:44, 25 February 2014Bart SmeetsAdded wikipedia database for UPR
73820view 07:40, 25 February 2014Bart SmeetsFew GeneIDs were added
70982view 13:29, 19 September 2013EgonwFound another gene ID.
70981view 13:18, 19 September 2013EgonwOne more gene identifier.
70980view 13:11, 19 September 2013EgonwModified description
70978view 12:58, 19 September 2013EgonwAdded a number of gene identifiers.
70960view 07:11, 18 September 2013Egonw
70486view 04:56, 7 August 2013EgonwAdded Wikpedia's DNA entry as identifier for "DNA".
65707view 05:30, 11 June 2013EgonwAdded a few caspase identifiers.
65021view 13:58, 4 June 2013MaintBotModified categories
64719view 01:36, 2 June 2013EgonwOntology Term : 'apoptotic cell death pathway' added !
64641view 02:35, 31 May 2013AnweshaChanged the node for apoptosis (made it a pathway node)
64613view 12:03, 30 May 2013EgonwAdding the last corner.
64576view 22:45, 29 May 2013EgonwAdded a bit I missed yesterday.
64575view 22:44, 29 May 2013EgonwAdded another section of the full pathway.
64545view 09:16, 29 May 2013EgonwFixed the data source. Should be PubChem-compound.
64544view 08:55, 29 May 2013EgonwAdded the ChEBI ID for the fullerenes.
64537view 05:39, 29 May 2013EgonwAdded the paper from which this is a figure.
64536view 05:36, 29 May 2013EgonwNew pathway

External references


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NameTypeDatabase referenceComment
AIFGeneProductENSG00000156709 (Ensembl)
APAF-1GeneProductENSG00000120868 (Ensembl)
APOPTOSISPathwayWP254 (WikiPathways)
Ag NPNPO_1892 (NanoParticle Ontology)
Au NPNPO_401 (NanoParticle Ontology)
BAKGeneProductENSG00000030110 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
BCL-2GeneProductGO:0097136 (GeneOntology)
CASP3GeneProductENSG00000164305 (Ensembl)
CASP6GeneProductENSG00000138794 (Ensembl)
CASP7GeneProductENSG00000165806 (Ensembl)
CASP8GeneProductENSG00000064012 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
Ca2+Metabolite271 (PubChem-compound)
Cyt CGeneProductENSG00000172115 (Ensembl)
DNAGeneProductDNA (Wikipedia)
EndoGGeneProductENSG00000167136 (Ensembl)
FADDGeneProductENSG00000168040 (Ensembl)
FASGeneProductENSG00000026103 (Ensembl)
FASLGGeneProductENSG00000117560 (Ensembl)
FLIPGeneProductENSG00000003402 (Ensembl)
HTRA2/OMIGeneProductENSG00000115317 (Ensembl)


NanohornNPO_457 (NanoParticle Ontology)
PAMAMNPO_965 (NanoParticle Ontology)
PerforinGeneProductENSG00000180644 (Ensembl)
Polystyrene NP
SMAC/DIABLOGeneProductENSG00000184047 (Ensembl)
TiO2 NPNPO_1485 (NanoParticle Ontology)
UPRGeneProductUnfolded protein response (Wikipedia)
tBIDGeneProductENSG00000015475 (Ensembl)

Annotated Interactions

<cite>No annotated interactions</cite>