Pathogenic Escherichia coli infection (Homo sapiens)

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Toxins EspF EspG2 ARHGEF2 Regulation of actin cytoskeleton ITGB1 CDC42 Phosphatidylethanolamine Eae StxA Adherens junction StxB Tight junction EspFU EspH TLR5 PRKCA LY96 NCL Bfp EspFU Map EspFU Regulation of actin cytoskeleton CTNNB1 RHOA Toll-like receptor signaling pathway CD14 CDH1 Tir EspG YWHAQ EspH TLR4 Apoptosis Tir ROCK1 ROCK2 hsa:6093 hsa:9475 CTTN HCLS1 hsa:2017 hsa:3059 Flagellar assembly EspG EspG2 WASL WAS hsa:7454 hsa:8976 OCLN EZR CLDN1 occludin-like NCK1 NCK2 hsa:4690 hsa:8440 EspF Map TUBB6 TUBB8 TUBB3 TUBB2B TUBB2C TUBB4 TUBB4Q TUBB1 TUBB TUBB2A hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617 ARPC5 actin-related protein 2/3 complex subunit 1B-like ARPC1A ARPC4 ARPC3 ARPC5L ARPC2 ARPC1B hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873 TUBA8 TUBA4A TUBA3C TUBA1C TUBA3E TUBA1A TUBA3D TUBA1B TUBAL3 hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790 KRT18 YWHAZ ACTG1 ACTB hsa:60 hsa:71 ABL1 FYN hsa:25 hsa:2534 Pathogen: Enteropathogenic escherichia coli (EPEC) Enterohermorrhagic escherichia coli (EHEC) Pilus LEE-encoded effectors non-LEE-encoded effectors Prophage-carried effectors Type III protein secretion system Flagellin LPS Host: Small intestinal epithelial cell (EPEC) Large intestinal epithelial cell (EHEC) NleH NleA Inflammation Stress fiber formation Pedestal formation Cytoskeleton rearrangement Disruption of microtuble network Retraction of filopodium Filipodium formation Alterations in the IF network architecture Disruption of tight junctions Disruption of adherens junctions Disruption of barrier function and increase in monolayer permeability Redistribution Mitochondrial dysfunction outer membrane protein p+ p+ Translocation Intestinal tract Kidney ....... Inhibition of protein synthesis TUBB6 TUBB1 TUBB4Q TUBB8 TUBB2B TUBB4 TUBB2C TUBB TUBB2A TUBB3 hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617 Name: Pathogenic Escherichia coli infection Organism: Homo sapiens


Description

Sources: KEGG Escherichia coli (commonly abbreviated E. coli) is a gram-negative, rod-shaped bacterium that is commonly found in the lower intestine of warm-blooded organisms (endotherms). Most E. coli strains are harmless, but some serotypes are pathogenic and can cause serious food poisoning in humans, and are occasionally responsible for product recalls. E. coli are also responsible for a majority of cases of urinary tract infections. The harmless strains are part of the normal flora of the gut, and can benefit their hosts by producing vitamin K2, and by preventing the establishment of pathogenic bacteria within the intestine.

Quality Tags

Ontology Terms

<OntologyTags></OntologyTags>

Bibliography

  1. Kaper, James B., James P. Nataro, Harry LT Mobley.; ''Pathogenic escherichia coli.''; Nature Reviews Microbiology, 2004

History

View all...
RevisionActionTimeUserComment
97629view 03:42, 31 May 2018AMTanOntology Term : 'epithelial cell of large intestine' added !
97628view 03:42, 31 May 2018AMTanOntology Term : 'epithelial cell of small intestine' added !
97525view 07:11, 24 May 2018AMTanSee below
97523view 07:02, 24 May 2018AMTanConverted some nodes to pathway nodes, updated them with our own pathways rather than KEGG genes pathways
95730view 14:06, 18 January 2018AlexanderPicoreplaced all kegg ortholog links with uniprot links for ecoli proteins
95729view 13:50, 18 January 2018AlexanderPicotesting uniprot for Ecoli
95728view 13:49, 18 January 2018AlexanderPicotesting uniprot for Ecoli
95727view 13:47, 18 January 2018AlexanderPicotesting uniprot for Ecoli
95377view 01:08, 11 December 2017DeSlRemoved last modified part
95376view 01:07, 11 December 2017DeSlAdded literature reference
95375view 01:03, 11 December 2017DeSlConnected unconnected line.
95374view 01:00, 11 December 2017DeSlModified description
95136view 19:26, 16 November 2017AlexanderPicoconnected interactions
78594view 07:51, 7 January 2015MaintBotadded missing graphIds
71367view 11:37, 17 October 2013MaintBotAutomated update of data sources
71225view 13:23, 15 October 2013MaintBotUpdated KEGG xrefs
71224view 13:20, 15 October 2013MaintBotUpdated KEGG Compound xrefs
68925view 10:33, 8 July 2013MaintBotUpdated to 2013 gpml schema
53131view 18:51, 29 October 2012AlexanderPicoModified description
53130view 18:50, 29 October 2012AlexanderPicoModified categories
53129view 18:50, 29 October 2012AlexanderPicoModified categories
50535view 20:03, 16 August 2012NsalomonisPeriodical save, work in progress
50465view 22:25, 15 August 2012NsalomonisModified description
50464view 22:25, 15 August 2012NsalomonisOntology Term : 'pathogenic Escherichia coli infection pathway' added !
50463view 22:21, 15 August 2012NsalomonisSpecify description
50462view 22:20, 15 August 2012NsalomonisSpecify description
50461view 22:16, 15 August 2012NsalomonisSpecify description
50460view 22:12, 15 August 2012NsalomonisPeriodical save, work in progress
50459view 22:10, 15 August 2012NsalomonisSpecify description
50458view 22:02, 15 August 2012NsalomonisPeriodical save, work in progress
50457view 21:52, 15 August 2012NsalomonisPeriodical save, work in progress
50454view 21:42, 15 August 2012NsalomonisPeriodical save, work in progress
50453view 21:31, 15 August 2012NsalomonisPeriodical save, work in progress
50452view 21:21, 15 August 2012NsalomonisPeriodical save, work in progress
50445view 16:25, 15 August 2012NsalomonisSpecify description
50444view 16:23, 15 August 2012NsalomonisSpecify description
50441view 16:21, 15 August 2012NsalomonisPeriodical save, work in progress
50436view 16:09, 15 August 2012NsalomonisSpecify description
50435view 16:06, 15 August 2012NsalomonisSpecify description
50434view 15:59, 15 August 2012NsalomonisPeriodical save, work in progress
50433view 15:34, 15 August 2012NsalomonisNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABL1GeneProduct25 (Entrez Gene)Original kegg element: gene;35;hsa:25 hsa:2534
ACTBGeneProduct60 (Entrez Gene)Original kegg element: gene;55;hsa:60 hsa:71
ACTG1GeneProduct71 (Entrez Gene)Original kegg element: gene;55;hsa:60 hsa:71
ARHGEF2GeneProduct9181 (Entrez Gene)Original kegg element: gene;42;hsa:9181
ARPC1AGeneProduct10552 (Entrez Gene)Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
ARPC1BGeneProduct10095 (Entrez Gene)Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
ARPC2GeneProduct10109 (Entrez Gene)Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
ARPC3GeneProduct10094 (Entrez Gene)Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
ARPC4GeneProduct10093 (Entrez Gene)Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
ARPC5GeneProduct10092 (Entrez Gene)Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
ARPC5LGeneProduct81873 (Entrez Gene)Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
Adherens junctionPathwaypath:hsa04520 (KEGG Genes)Original kegg element: map;5;path:hsa04520
ApoptosisPathwayWP254 (WikiPathways)
  • Original kegg element: map;19;path:hsa04210
  • WP254
BfpGeneProductQ0H044 (Uniprot-TrEMBL)
CD14GeneProduct929 (Entrez Gene)Original kegg element: gene;2;hsa:929
CDC42GeneProduct998 (Entrez Gene)Original kegg element: gene;32;hsa:998
CDH1GeneProduct999 (Entrez Gene)Original kegg element: gene;17;hsa:999
CLDN1GeneProduct9076 (Entrez Gene)Original kegg element: gene;39;hsa:9076
CTNNB1GeneProduct1499 (Entrez Gene)Original kegg element: gene;26;hsa:1499
CTTNGeneProduct2017 (Entrez Gene)Original kegg element: gene;27;hsa:2017 hsa:3059
EZRGeneProduct7430 (Entrez Gene)Original kegg element: gene;31;hsa:7430
EaeGeneProductP43261 (Uniprot-TrEMBL)
EspFGeneProductO85622 (Uniprot-TrEMBL)
EspFUGeneProductP0DJ88 (Uniprot-TrEMBL)
EspG2GeneProductQ9EZE8 (Uniprot-TrEMBL)
EspGGeneProductO85646 (Uniprot-TrEMBL)
EspHGeneProductO85629 (Uniprot-TrEMBL)
FYNGeneProduct2534 (Entrez Gene)Original kegg element: gene;35;hsa:25 hsa:2534
Flagellar assemblyPathwaypath:map02040 (KEGG Genes)Original kegg element: map;4;path:map02040
HCLS1GeneProduct3059 (Entrez Gene)Original kegg element: gene;27;hsa:2017 hsa:3059
ITGB1GeneProduct3688 (Entrez Gene)Original kegg element: gene;40;hsa:3688
KRT18GeneProduct3875 (Entrez Gene)Original kegg element: gene;25;hsa:3875
LY96GeneProduct23643 (Entrez Gene)Original kegg element: gene;3;hsa:23643
MapGeneProductQ9R8E4 (Uniprot-TrEMBL)
NCK1GeneProduct4690 (Entrez Gene)Original kegg element: gene;41;hsa:4690 hsa:8440
NCK2GeneProduct8440 (Entrez Gene)Original kegg element: gene;41;hsa:4690 hsa:8440
NCLGeneProduct4691 (Entrez Gene)Original kegg element: gene;45;hsa:4691
NleAGeneProductQ71HP5 (Uniprot-TrEMBL)
NleHGeneProductD3QNI6 (Uniprot-TrEMBL)
OCLNGeneProduct4950 (Entrez Gene)Original kegg element: gene;30;hsa:100506658 hsa:4950
PRKCAGeneProduct5578 (Entrez Gene)Original kegg element: gene;36;hsa:5578
PhosphatidylethanolamineMetaboliteC00350 (KEGG Compound)
RHOAGeneProduct387 (Entrez Gene)Original kegg element: gene;44;hsa:387
ROCK1GeneProduct6093 (Entrez Gene)Original kegg element: gene;28;hsa:6093 hsa:9475
ROCK2GeneProduct9475 (Entrez Gene)Original kegg element: gene;28;hsa:6093 hsa:9475
Regulation of actin cytoskeletonPathwayWP51 (WikiPathways)
  • Original kegg element: map;1;path:hsa04810
  • WP51
StxAGeneProductA8B1H9 (Uniprot-TrEMBL)
StxBGeneProductA7UQX3 (Uniprot-TrEMBL)
TLR4GeneProduct7099 (Entrez Gene)Original kegg element: gene;9;hsa:7099
TLR5GeneProduct7100 (Entrez Gene)Original kegg element: gene;10;hsa:7100
TUBA1AGeneProduct7846 (Entrez Gene)Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
TUBA1BGeneProduct10376 (Entrez Gene)Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
TUBA1CGeneProduct84790 (Entrez Gene)Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
TUBA3CGeneProduct7278 (Entrez Gene)Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
TUBA3DGeneProduct113457 (Entrez Gene)Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
TUBA3EGeneProduct112714 (Entrez Gene)Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
TUBA4AGeneProduct7277 (Entrez Gene)Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
TUBA8GeneProduct51807 (Entrez Gene)Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
TUBAL3GeneProduct79861 (Entrez Gene)Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
TUBB1GeneProduct81027 (Entrez Gene)Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
TUBBGeneProduct203068 (Entrez Gene)Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
TUBB2AGeneProduct7280 (Entrez Gene)Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
TUBB2BGeneProduct347733 (Entrez Gene)Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
TUBB2CGeneProduct10383 (Entrez Gene)Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
TUBB3GeneProduct10381 (Entrez Gene)Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
TUBB4GeneProduct10382 (Entrez Gene)Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
TUBB4QGeneProduct56604 (Entrez Gene)Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
TUBB6GeneProduct84617 (Entrez Gene)Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
TUBB8GeneProduct347688 (Entrez Gene)Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
Tight junctionPathwaypath:hsa04530 (KEGG Genes)Original kegg element: map;6;path:hsa04530
TirGeneProductP0DJ92 (Uniprot-TrEMBL)
Toll-like receptor signaling pathwayPathwayWP75 (WikiPathways)
  • Original kegg element: map;7;path:hsa04620
  • WP75
Type III protein secretion systemGeneProductOriginal kegg element: map;4;path:map02040
WASGeneProduct7454 (Entrez Gene)Original kegg element: gene;37;hsa:7454 hsa:8976
WASLGeneProduct8976 (Entrez Gene)Original kegg element: gene;37;hsa:7454 hsa:8976
YWHAQGeneProduct10971 (Entrez Gene)Original kegg element: gene;18;hsa:10971
YWHAZGeneProduct7534 (Entrez Gene)Original kegg element: gene;23;hsa:7534
actin-related protein 2/3 complex subunit 1B-likeGeneProduct653888 (Entrez Gene)Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
occludin-likeGeneProduct100506658 (Entrez Gene)Original kegg element: gene;30;hsa:100506658 hsa:4950

Annotated Interactions

<cite>No annotated interactions</cite>