Pilocytic astrocytoma (Homo sapiens)

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Cytoplasmic targets BRAF Cell growth, survival,motility CYTOPLASAM RAF1 MEK NUCLEUS TRANSFER FACTOR ERK SOS1 GRB2 PTPN11 NF1 RTK RAS:GTP RAS:GDP Name: Pilocytic astrocytoma Last Modified: 2/22/2013 Organism: Homo sapiens


In this pathway shows the signaling in the development and behavior of the disease. receptor tyrosine kinase(rtk) is expressed in tumor endothelial cells of adult glioblastomas.NF1 and BRAF genes induced the tumor growth.

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Ontology Terms



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94224view 15:42, 25 August 2017DeSlChanged RTK metabolite node to protein node, added ID for this node.
74520view 14:34, 28 April 2014KhanspersModified title
69013view 10:47, 8 July 2013MaintBotUpdated to 2013 gpml schema
67597view 04:31, 26 June 2013DdiglesOntology Term : 'glioma pathway' added !
59199view 12:14, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
54370view 08:01, 28 November 2012MaintBotremoved mim-gap end type
53138view 19:00, 29 October 2012MaintBotModified categories
49791view 03:47, 26 July 2012DeviModified description
49790view 23:50, 25 July 2012DeviPilocytic astrocytoma
49771view 12:24, 25 July 2012MaintBotconnected nodes to database object
49739view 03:32, 25 July 2012DeviNew pathway

External references


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NameTypeDatabase referenceComment
GRB2GeneProductENSG00000177885 (Ensembl)
NF1GeneProductENSG00000196712 (Ensembl)
PTPN11GeneProductENSG00000179295 (Ensembl)
RAS:GDPMetaboliteHMDB00960 (HMDB)
RAS:GTPMetaboliteHMDB01440 (HMDB)
RTKProteinEC (Enzyme Nomenclature)
SOS1GeneProductENSG00000115904 (Ensembl)

Annotated Interactions

<cite>No annotated interactions</cite>