Metastatic brain tumor (Homo sapiens)

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DNMTs CpG hypermethylation Metastasis E2F3 TP53 CDC42 P85A_HUMAN TTP CDK6 MYC E2H2 MIR148A MIR148B MIR34A MIR34B MIR34C MIR29A MIR29B1 MIR29B2 MIR29C MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIR101-1 MIR101-2 Name: Metastatic brain tumor Organism: Homo sapiens


Interaction between microRNAs (miRNAs) and abnormal methylation to control metastasis. Tumor growth and metastasis formation through down regulation of their oncogenic targets such as MYC ,E2F3 and cyclin-dependent kinase(CDK6).

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Ontology Terms



  1. Park SY, Lee JH, Ha M, Nam JW, Kim VN; ''miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42.''; Nat Struct Mol Biol, 2009 PubMed
  2. Christoffersen NR, Shalgi R, Frankel LB, Leucci E, Lees M, Klausen M, Pilpel Y, Nielsen FC, Oren M, Lund AH; ''p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC.''; Cell Death Differ, 2010 PubMed
  3. Hermeking H; ''The miR-34 family in cancer and apoptosis.''; Cell Death Differ, 2010 PubMed
  4. Hafner M, Landthaler M, Burger L, Khorshid M, Hausser J, Berninger P, Rothballer A, Ascano M Jr, Jungkamp AC, Munschauer M, Ulrich A, Wardle GS, Dewell S, Zavolan M, Tuschl T; ''Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.''; Cell, 2010 PubMed


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89836view 05:10, 6 October 2016MkutmonModified description
87807view 04:28, 25 July 2016ElisaOntology Term : 'disease of cellular proliferation' added !
87806view 04:27, 25 July 2016ElisaOntology Term : 'disease pathway' added !
84646view 14:18, 10 March 2016KhanspersQuick edit to datanode annotation or property
84484view 15:57, 25 February 2016KhanspersQuick edit to datanode annotation or property
84483view 15:56, 25 February 2016KhanspersQuick edit to datanode annotation or property
80457view 14:47, 24 June 2015KhanspersAdded some literature references for miRNA targeting
76471view 15:11, 9 July 2014KhanspersAdded data nodes, fixed layout and interactions
73839view 17:10, 25 February 2014MaintBotupdated schema
58199view 14:39, 9 February 2013EgonwConnected dots.
57902view 13:05, 4 February 2013MaintBotModified categories
49794view 04:02, 26 July 2012DeviModified description
49677view 02:47, 24 July 2012Devimetastatic brain tumor
49671view 22:53, 23 July 2012DeviNew pathway

External references


View all...
NameTypeDatabase referenceComment
CDC42GeneProductENSG00000070831 (Ensembl)
CDK6GeneProductENSG00000105810 (Ensembl)
E2F3GeneProductENSG00000112242 (Ensembl)
MIR101-1RnaENSG00000199135 (Ensembl)
MIR101-2RnaENSG00000199065 (Ensembl)
MIR148ARnaENSG00000199085 (Ensembl)
MIR148BRnaENSG00000199122 (Ensembl)
MIR29AGeneProductENSG00000277934 (Ensembl)
MIR29B1Rna407024 (Entrez Gene)
MIR29B2Rna407025 (Entrez Gene)
MIR29CGeneProductENSG00000275668 (Ensembl)
MIR34ARnaENSG00000207865 (Ensembl)
MIR34BRnaENSG00000207811 (Ensembl)
MIR34CRnaENSG00000207562 (Ensembl)
MIRLET7A1GeneProductENSG00000199165 (Ensembl)
MIRLET7A2Rna406882 (Entrez Gene)
MIRLET7A3GeneProductENSG00000198986 (Ensembl)
MIRLET7BRna406884 (Entrez Gene)
MIRLET7CGeneProductENSG00000199030 (Ensembl)
MIRLET7DGeneProductENSG00000199133 (Ensembl)
MIRLET7EGeneProductENSG00000198972 (Ensembl)
MIRLET7F1GeneProductENSG00000199072 (Ensembl)
MIRLET7F2Rna406889 (Entrez Gene)
MIRLET7GGeneProductENSG00000199150 (Ensembl)
MYCGeneProductENSG00000136997 (Ensembl)
P85A_HUMANProteinP27986 (Uniprot-TrEMBL)
TP53GeneProductENSG00000141510 (Ensembl)

Annotated Interactions

<cite>No annotated interactions</cite>