Endothelin Pathways (Homo sapiens)

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Sensory motor nerve Vasocontriction SERCA eNOS NO L-Arginine Citrulline COX2 PGI2 Arachidonic acid EDHF K+ channel Ca2+ channel K+ IP1 AC ATP cAMP PKA a adrenergic receptor K+ CGRP CRLR RAMP1 NPY Y1 sGC GTP cGMP Ca2+ channel Endothelin 1 ECE IP3 Cap PKC GaQ GbQ GgQ MLC Big ET1 MEK EDNRA MLCK DAG ERK1/2 EDNRB Furin-like protease RAF PLCb IP3R Pre-pro ET1 CAD Ca2+ CaM PIP2 Pre-pro ET1 Endothelin 1 Ca2+ PMCA Ca2+ EDNRB GaQ GbQ GgQ PLCb PIP2 IP3 DAG Ca2+ Ca2+ Ca2+ channel IP3R NO PGI2 PKC Ca2+ K+ GaS GbS GgS GaQ GbQ GgQ b adrenergic receptor GaS GbS GgS Sympathic nerve Endothelial cell Smooth muscle cell K+ CGRP CGRP GaS GbS GgS K+ K+ NPY NPY GaI GbI GgI NO NO Ca2+ Cellular growth and survival Name: Endothelin Pathways Last Modified: 10/17/2013 Organism: Homo sapiens


Description

Endothelin-1 is a bicyclic 21 amino acid peptide, produced primarily in the endothelium. It is a potent stimulus of long-lasting and persistent vasoconstriction. It also has a role as a stimulus of inflammation, oxidative stress and cellular proliferation.

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Ontology Terms

<OntologyTags></OntologyTags>

Bibliography

No bibliography

History

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RevisionActionTimeUserComment
94181view 06:41, 25 August 2017Mkutmonadded missing metabolite identifiers
74852view 01:47, 1 May 2014SabinedaemenSpecify description
71380view 11:39, 17 October 2013MaintBotAutomated update of data sources
69912view 12:37, 11 July 2013AlexanderPicoModified title
67194view 03:19, 26 June 2013Christine ChichesterOntology Term : 'endothelin signaling pathway' added !
64830view 14:33, 3 June 2013MaintBotModified title
63181view 13:43, 8 May 2013MaintBotUpdating gpml version
59179view 11:44, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
57671view 13:17, 31 January 2013KhanspersModified categories
56443view 14:38, 7 January 2013EgonwAdded missing HMDB data source values.
48538view 00:48, 3 June 2012MireilleSthijnsPeriodical save, work in progress
48535view 03:31, 2 June 2012MireilleSthijnsPeriodical save, work in progress
48447view 08:13, 24 May 2012Sabinedaemen
48446view 08:10, 24 May 2012Sabinedaemen
48435view 03:42, 24 May 2012Sabinedaemen
48434view 03:39, 24 May 2012Sabinedaemen
48433view 03:30, 24 May 2012SabinedaemenModified description
48432view 03:20, 24 May 2012Sabinedaemen
48431view 03:15, 24 May 2012Sabinedaemen
48430view 03:13, 24 May 2012Sabinedaemen
48429view 03:09, 24 May 2012SabinedaemenPeriodical save, work in progress
48428view 03:01, 24 May 2012SabinedaemenSpecify description
48427view 02:52, 24 May 2012SabinedaemenOntology Term : 'Ras superfamily mediated signaling pathway' added !
48426view 02:51, 24 May 2012SabinedaemenOntology Term : 'calcium/calmodulin dependent signaling pathway' added !
48425view 02:50, 24 May 2012SabinedaemenOntology Term : 'hypertension' added !
48424view 02:49, 24 May 2012SabinedaemenOntology Term : 'smooth muscle cell' added !
48423view 02:49, 24 May 2012SabinedaemenOntology Term : 'blood vessel endothelial cell' added !
48422view 02:47, 24 May 2012SabinedaemenOntology Term : 'benign essential hypertension' added !
48421view 02:44, 24 May 2012SabinedaemenOntology Term : 'G protein mediated signaling pathway via Galphas family' added !
48420view 02:43, 24 May 2012SabinedaemenOntology Term : 'G protein mediated signaling pathway via Galphaq family' added !
48419view 02:42, 24 May 2012SabinedaemenOntology Term : 'G protein mediated signaling pathway via Galphai family' added !
48418view 02:40, 24 May 2012SabinedaemenSpecify description
48417view 02:37, 24 May 2012MireilleSthijnsSpecify description
48416view 02:34, 24 May 2012MireilleSthijnsPeriodical save, work in progress
48415view 02:29, 24 May 2012MireilleSthijnsSpecify description
48414view 02:23, 24 May 2012MireilleSthijnsSpecify description
48413view 02:14, 24 May 2012MireilleSthijnsPeriodical save, work in progress
48412view 02:04, 24 May 2012MireilleSthijnsPeriodical save, work in progress
48411view 01:59, 24 May 2012MireilleSthijnsSpecify description
48410view 01:54, 24 May 2012MireilleSthijnsPeriodical save, work in progress
48409view 01:43, 24 May 2012MireilleSthijnsPeriodical save, work in progress
48408view 01:33, 24 May 2012MireilleSthijnsSpecify description
48407view 01:31, 24 May 2012MireilleSthijnsSpecify description
48406view 01:23, 24 May 2012MireilleSthijnsPeriodical save, work in progress
48405view 01:04, 24 May 2012MireilleSthijnsSpecify description
48404view 01:03, 24 May 2012MireilleSthijnsPeriodical save, work in progress
48403view 00:54, 24 May 2012MireilleSthijnsSpecify description
48402view 00:53, 24 May 2012MireilleSthijnsPeriodical save, work in progress
48401view 00:41, 24 May 2012MireilleSthijnsPeriodical save, work in progress
48398view 00:18, 24 May 2012SabinedaemenSpecify description

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACGeneProductENSG00000143199 (Ensembl)adenylate cyclase
ATPMetaboliteHMDB01532 (HMDB)
Arachidonic acidMetaboliteHMDB01043 (HMDB)
Big ET1Protein
CADGeneProductENSG00000084774 (Ensembl)
  • Calmodulin binding protein; tonically inhibits the ATPase activity of myosin in smoothe muscle; mediating factor for Ca2+ dependent inhibition of smooth muscle contraction
  • Type your comment here
CGRPGeneProductENSG00000110680 (Ensembl)
COX2GeneProduct4513 (Entrez Gene)
CRLRGeneProductENSG00000064989 (Ensembl)
Ca2+ channelGeneProduct
Ca2+MetaboliteHMDB00464 (HMDB)
CaMGeneProductENSG00000198668 (Ensembl)
CapGeneProductENSG00000130176 (Ensembl)
  • Calponin; tonically inhibits the ATPase activity of myosin in smooth muscle
  • Type your comment here
CitrullineMetaboliteHMDB00904 (HMDB)
DAGMetaboliteHMDB07008 (HMDB)
ECEGeneProductENSG00000117298 (Ensembl)
EDHFProtein
EDNRAGeneProductENSG00000151617 (Ensembl)
EDNRBGeneProductENSG00000136160 (Ensembl)
ERK1/2GeneProductENSG00000100030 (Ensembl)
Endothelin 1GeneProductENSG00000078401 (Ensembl)
Furin-like proteaseProtein
GTPMetaboliteHMDB01440 (HMDB)
GaIGeneProductENSG00000127955 (Ensembl)
GaQGeneProductENSG00000060558 (Ensembl)
GaSGeneProductENSG00000087460 (Ensembl)
GbIGeneProductENSG00000069966 (Ensembl)
GbQGeneProductENSG00000069966 (Ensembl)
GbSGeneProductENSG00000069966 (Ensembl)
GgIGeneProductENSG00000127588 (Ensembl)
GgQGeneProductENSG00000127588 (Ensembl)
GgSGeneProductENSG00000127588 (Ensembl)
IP1GeneProductENSG00000160013 (Ensembl)Prostaglandin I2 Receptor
IP3MetaboliteHMDB01059 (HMDB)
IP3RProtein
K+ channelProtein
K+MetaboliteHMDB00586 (HMDB)
L-ArginineMetaboliteHMDB00517 (HMDB)
MEKGeneProductENSG00000169032 (Ensembl)
MLCGeneProductENSG00000168530 (Ensembl)myosine light chain
MLCKGeneProductENSG00000065534 (Ensembl)
NOMetaboliteHMDB03378 (HMDB)
NPYGeneProductENSG00000122585 (Ensembl)
PGI2MetaboliteQ412050 (Wikidata)
PIP2MetaboliteHMDB10032 (HMDB)
PKAGeneProductENSG00000178796 (Ensembl)
PKCGeneProductENSG00000154229 (Ensembl)
PLCbGeneProductENSG00000182621 (Ensembl)
PMCAProtein
Pre-pro ET1Protein
RAFGeneProductENSG00000132155 (Ensembl)
RAMP1GeneProductENSG00000132329 (Ensembl)
SERCAGeneProductENSG00000174437 (Ensembl)
Y1GeneProductENSG00000164128 (Ensembl)
a adrenergic receptorGeneProductENSG00000120907 (Ensembl)
b adrenergic receptorGeneProductENSG00000043591 (Ensembl)
cAMPMetaboliteHMDB00058 (HMDB)
cGMPMetaboliteHMDB01314 (HMDB)
eNOSGeneProductENSG00000164867 (Ensembl)
sGCGeneProductENSG00000123201 (Ensembl)

Annotated Interactions

<cite>No annotated interactions</cite>