Effects of Nitric Oxide (Homo sapiens)

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Hypoxia Increased mitochondrial efficiency reduced risk of carciovascular disease cGMP signalling Vasodilation anti-inflammatory effects NOS family NOS3 (endothelial) NOS1 (neuronal) NOS2 (inducible) Increased risk of carcinogenesis NOS Family formation of nitrosilating species Nitric oxide AOX1 deoxy-hemoglobin deoxy-myoglobin Nitrate COX1 Citrulline VItamin C Nitrite XDH L-Arginine Oxygen Diet Name: Effects of Nitric Oxide Last Modified: 2/22/2013 Organism: Homo sapiens


NO (Nitric oxide) is an important signalling molecule with vasodilatory and anti-inflammatory effects, indicating a postive role in reducing hypertension and cardiovascular disease. At the same time, NO is also associated with health risks such as increased risk in carcinogenesis, and hypoxia in infants. It has been suggested that NO can also increase mitochondrial efficiency. NO can be formed from L-Arginine through the classic Arginine-NO-Synthase pathway, or it can be formed directly from dietary nitrite by deoxiginated globins.

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Ontology Terms



  1. Hord NG, Tang Y, Bryan NS; ''Food sources of nitrates and nitrites: the physiologic context for potential health benefits.''; Am J Clin Nutr, 2009 PubMed
  2. Larsen FJ, Schiffer TA, Borniquel S, Sahlin K, Ekblom B, Lundberg JO, Weitzberg E; ''Dietary inorganic nitrate improves mitochondrial efficiency in humans.''; Cell Metab, 2011 PubMed
  3. Lundberg JO, Gladwin MT, Ahluwalia A, Benjamin N, Bryan NS, Butler A, Cabrales P, Fago A, Feelisch M, Ford PC, Freeman BA, Frenneaux M, Friedman J, Kelm M, Kevil CG, Kim-Shapiro DB, Kozlov AV, Lancaster JR Jr, Lefer DJ, McColl K, McCurry K, Patel RP, Petersson J, Rassaf T, Reutov VP, Richter-Addo GB, Schechter A, Shiva S, Tsuchiya K, van Faassen EE, Webb AJ, Zuckerbraun BS, Zweier JL, Weitzberg E; ''Nitrate and nitrite in biology, nutrition and therapeutics.''; Nat Chem Biol, 2009 PubMed


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88595view 12:44, 11 August 2016Mkutmonfix unconnected lines
69910view 12:35, 11 July 2013AlexanderPicoReplaced datanodes with labels
69907view 12:32, 11 July 2013AlexanderPicoModified title
63176view 13:30, 8 May 2013MaintBotUpdating gpml version
59194view 12:07, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
44467view 13:13, 14 September 2011MaintBotModified categories
43380view 06:50, 17 June 2011MartijnVanIerselModified description
43379view 06:43, 17 June 2011MartijnVanIerselOntology Term : 'cardiovascular system homeostasis pathway' added !
43377view 06:41, 17 June 2011MartijnVanIersellitrefs
43372view 04:22, 17 June 2011MartijnVanIerselvarious
43371view 04:14, 17 June 2011MartijnVanIerselNew pathway

External references


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NameTypeDatabase referenceComment
AOX1ProteinENSG00000138356 (Ensembl)
COX1GeneProduct4512 (Entrez Gene)
CitrullineMetaboliteHMDB00904 (HMDB)
L-ArginineMetaboliteHMDB00517 (HMDB)
NOS1 (neuronal)GeneProduct4842 (Entrez Gene)
NOS2 (inducible)GeneProduct4843 (Entrez Gene)
NOS3 (endothelial)GeneProduct4846 (Entrez Gene)
NitrateMetaboliteHMDB02878 (HMDB)
Nitric oxideMetaboliteHMDB03378 (HMDB)
NitriteMetaboliteHMDB02786 (HMDB)
OxygenMetaboliteHMDB01377 (HMDB)
VItamin CMetaboliteHMDB00044 (HMDB)
XDHGeneProductENSG00000158125 (Ensembl)
deoxy-hemoglobinGeneProductENSG00000206172 (Ensembl)
deoxy-myoglobinGeneProduct4151 (Entrez Gene)

Annotated Interactions

<cite>No annotated interactions</cite>