Integrated Cancer Pathway (Homo sapiens)

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BASC Comlex BLM_HUMAN MSH2_HUMAN MSH6_HUMAN Q8NBS1_HUMAN MRE11_HUMAN RAD50_HUMAN ATM_HUMAN CHK2_HUMAN Cctlp DNA-PK P53_HUMAN BRCA1_HUMAN STAT1_HUMAN ATF1 E2F1_HUMAN RB_HUMAN CHK1_HUMAN PLK1 OCT1 Swi/SNF BACH1 BRCA1_HUMAN BARD1_HUMAN ATR_HUMAN AKT1_HUMAN ASK1 MDM2_HUMAN CDK4_HUMAN p14 SMAD2_HUMAN SMAD3_HUMAN p21 p27 p15 BCL2_HUMAN BAD_HUMAN BAX_HUMAN NOXA1_HUMAN PUMA MMP1_HUMAN CDC25A CDC25B CDC2_HUMAN MYC p38 JAK1_HUMAN p13K CDK2_HUMAN CASP8_HUMAN CASP3_HUMAN PTEN_HUMAN CASP9_HUMAN MIR21 MIR29B1 MIR29B2 MIR29C Name: Integrated Cancer Pathway License: CC BY 2.0 Last Modified: 10/16/2013 Organism: Homo sapiens


Description

This integrated cancer pathway describes the key mechanisms involved in the development of cancer containing the key prognostic markers and pathogenetic factors.

Quality Tags

Ontology Terms

<OntologyTags></OntologyTags>

Bibliography

  1. Gabriely G, Wurdinger T, Kesari S, Esau CC, Burchard J, Linsley PS, Krichevsky AM; ''MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators.''; Mol Cell Biol, 2008 PubMed
  2. Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, Patel T; ''MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer.''; Gastroenterology, 2007 PubMed
  3. Zhao JJ, Lin J, Lwin T, Yang H, Guo J, Kong W, Dessureault S, Moscinski LC, Rezania D, Dalton WS, Sotomayor E, Tao J, Cheng JQ; ''microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma.''; Blood, 2010 PubMed
  4. Wang C, Bian Z, Wei D, Zhang JG; ''miR-29b regulates migration of human breast cancer cells.''; Mol Cell Biochem, 2011 PubMed

History

View all...
RevisionActionTimeUserComment
96025view 08:33, 15 February 2018MkutmonModified description
82939view 01:51, 14 November 2015EgonwUpdated Ensembl identifiers.
82938view 01:31, 14 November 2015EgonwFixed a small topy in a comment.
82936view 15:43, 13 November 2015AlexanderPicoModified title
80447view 23:15, 22 June 2015KhanspersAdded mir29 targeting to PTEN
80431view 13:03, 22 June 2015KhanspersAdded mir21 targeting of CDC25A
80425view 11:50, 22 June 2015KhanspersAdded mi21 targeting, cleaned up layout, connected lines and added some xrefs
71249view 13:29, 16 October 2013MaintBotAutomated update of data sources
67398view 03:56, 26 June 2013DdiglesOntology Term : 'cancer pathway' added !
63221view 14:01, 8 May 2013MaintBotUpdating gpml version
59118view 15:27, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
44858view 02:54, 6 October 2011MartijnVanIerselOntology Term : 'cancer' added !
44469view 13:30, 14 September 2011MaintBotAdded category
42356view 16:30, 19 March 2011SaibrahiSpecify description
42355view 16:20, 19 March 2011SaibrahiPeriodical save, work in progress
42354view 15:22, 19 March 2011SaibrahiSpecify description
42262view 14:45, 11 March 2011AlexanderPicoConnected BRCA1 to database
42257view 07:35, 11 March 2011SaibrahiSpecify description
42256view 07:31, 11 March 2011SaibrahiPeriodical save, work in progress
41986view 04:44, 4 March 2011SaibrahiSpecify description
41985view 04:36, 4 March 2011SaibrahiPeriodical save, work in progress
41984view 04:26, 4 March 2011SaibrahiPeriodical save, work in progress
41976view 19:50, 3 March 2011SaibrahiPeriodical save, work in progress
41975view 19:48, 3 March 2011SaibrahiSpecify description
41076view 16:20, 1 March 2011MaintBotRemoved redundant pathway information and comments
40454view 10:45, 1 March 2011SaibrahiPeriodical save, work in progress
40442view 13:41, 25 February 2011SaibrahiPeriodical save, work in progress
40439view 08:07, 25 February 2011SaibrahiSpecify description
40438view 07:57, 25 February 2011SaibrahiPeriodical save, work in progress
40437view 07:55, 25 February 2011SaibrahiSpecify description
40436view 07:47, 25 February 2011SaibrahiPeriodical save, work in progress
40435view 07:37, 25 February 2011SaibrahiPeriodical save, work in progress
40432view 07:26, 25 February 2011SaibrahiSpecify description
40430view 04:26, 25 February 2011SaibrahiNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1_HUMANProteinP31749 (Uniprot-TrEMBL)
ASK1Protein4217 (Entrez Gene)
ATF1GeneProductENSG00000123268 (Ensembl)
ATM_HUMANProteinQ13315 (Uniprot-TrEMBL)
ATR_HUMANProteinQ13535 (Uniprot-TrEMBL)
BACH1GeneProductENSG00000156273 (Ensembl)
BAD_HUMANProteinQ92934 (Uniprot-TrEMBL)
BARD1_HUMANProteinQ99728 (Uniprot-TrEMBL)
BAX_HUMANProteinQ07812 (Uniprot-TrEMBL)
BCL2_HUMANProteinP10415 (Uniprot-TrEMBL)
BLM_HUMANProteinP54132 (Uniprot-TrEMBL)
BRCA1_HUMANProteinP38398 (Uniprot-TrEMBL)
CASP3_HUMANProteinP42574 (Uniprot-TrEMBL)
CASP8_HUMANProteinQ14790 (Uniprot-TrEMBL)
CASP9_HUMANProteinP55211 (Uniprot-TrEMBL)
CDC25AGeneProductENSG00000164045 (Ensembl)
CDC25BGeneProductENSG00000101224 (Ensembl)
CDC2_HUMANProteinP06493 (Uniprot-TrEMBL)Oncogene
CDK2_HUMANProteinP24941 (Uniprot-TrEMBL)
CDK4_HUMANProteinP11802 (Uniprot-TrEMBL)
CHK1_HUMANProteinO14757 (Uniprot-TrEMBL)
CHK2_HUMANProteinO96017 (Uniprot-TrEMBL)Phosphorylated
CctlpProtein
DNA-PKMetabolite
E2F1_HUMANProteinQ01094 (Uniprot-TrEMBL)
JAK1_HUMANProteinP23458 (Uniprot-TrEMBL)
MDM2_HUMANProteinQ00987 (Uniprot-TrEMBL)Oncogene
MIR21RnaENSG00000199004 (Ensembl)
MIR29B1RnaENSG00000274250 (Ensembl)
MIR29B2RnaENSG00000276752 (Ensembl)
MIR29CRnaENSG00000275668 (Ensembl)
MMP1_HUMANProteinP03956 (Uniprot-TrEMBL)
MRE11_HUMANProteinP49959 (Uniprot-TrEMBL)
MSH2_HUMANProteinP43246 (Uniprot-TrEMBL)
MSH6_HUMANProteinP52701 (Uniprot-TrEMBL)
MYCGeneProductENSG00000136997 (Ensembl)
NOXA1_HUMANProteinQ86UR1 (Uniprot-TrEMBL)
OCT1Protein5451 (Entrez Gene)
P53_HUMANProteinP04637 (Uniprot-TrEMBL)
PLK1GeneProductENSG00000166851 (Ensembl)
PTEN_HUMANProteinP60484 (Uniprot-TrEMBL)
PUMAProtein27113 (Entrez Gene)
Q8NBS1_HUMANProteinQ8NBS1 (Uniprot-TrEMBL)
RAD50_HUMANProteinQ92878 (Uniprot-TrEMBL)
RB_HUMANProteinP06400 (Uniprot-TrEMBL)
SMAD2_HUMANProteinQ15796 (Uniprot-TrEMBL)Tumor supressor
SMAD3_HUMANProteinP84022 (Uniprot-TrEMBL)
STAT1_HUMANProteinP42224 (Uniprot-TrEMBL)
Swi/SNFProtein
p13KProtein
p14Protein
p15Protein1030 (Entrez Gene)
p21Protein1026 (Entrez Gene)
p27Protein1027 (Entrez Gene)
p38Protein

Annotated Interactions

<cite>No annotated interactions</cite>